Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104470927> ?p ?o ?g. }
- W3104470927 endingPage "1141" @default.
- W3104470927 startingPage "1141" @default.
- W3104470927 abstract "One-carbon (1C) metabolism is a metabolic network that is centered on folate, a B vitamin; it integrates nutritional signals with biosynthesis, redox homeostasis, and epigenetics. This metabolic pathway also reduces levels of homocysteine, a non-protein amino acid. High levels of homocysteine are linked to increased risk of hypoxic events, such as stroke. Several preclinical studies have suggested that 1C metabolism can impact stroke outcome, but the clinical data are unclear. The objective of this paper was to review preclinical and clinical research to determine whether 1C metabolism has an antioxidant role on stroke. To accomplish the objective, we searched for publications using the following medical subject headings (MeSH) keywords: antioxidants, hypoxia, stroke, homocysteine, one-carbon metabolism, folate, methionine, and dietary supplementation of one-carbon metabolism. Both pre-clinical and clinical studies were retrieved and reviewed. Our review of the literature suggests that deficiencies in 1C play an important role in the onset and outcome of stroke. Dietary supplementation of 1C provides beneficial effects on stroke outcome. For stroke-affected patients or individuals at high risk for stroke, the data suggest that nutritional modifications in addition to other therapies could be incorporated into a treatment plan." @default.
- W3104470927 created "2020-11-23" @default.
- W3104470927 creator A5032897794 @default.
- W3104470927 creator A5038853672 @default.
- W3104470927 creator A5042905167 @default.
- W3104470927 creator A5047277069 @default.
- W3104470927 creator A5050100900 @default.
- W3104470927 creator A5075801385 @default.
- W3104470927 date "2020-11-17" @default.
- W3104470927 modified "2023-10-01" @default.
- W3104470927 title "The Antioxidant Role of One-Carbon Metabolism on Stroke" @default.
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