FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104518559> ?p ?o ?g. }

• W3104518559 abstract "In spite of growing evidence supporting the occurrence of complex interactions between Schistosoma and gut bacteria in mice and humans, no data is yet available on whether worm-mediated changes in microbiota composition are dependent on the baseline gut microbial profile of the vertebrate host, and on the impact of such changes on the susceptibility to, and pathophysiology of, schistosomiasis. In this study, mice colonized with gut microbial populations from a human donor (HMA mice), as well as microbiota-wild type (WT) animals, were infected with Schistosoma mansoni, and alterations of their gut microbial profiles at 50 days post-infection were compared to those occurring in uninfected HMA and WT rodents, respectively. Significantly higher worm and egg burdens, together with increased specific antibody responses to parasite antigens, were observed in HMA compared to WT mice. These differences were associated with extensive dissimilarities between the gut microbial profiles of each HMA and WT groups of mice at baseline; in particular, the gut microbiota of HMA animals was characterized by low microbial alpha diversity and expanded Proteobacteria, as well as by the absence of putative immunomodulatory bacteria (e.g. Lactobacillus). Furthermore, differences in infection-associated changes in gut microbiota composition were observed between HMA and WT mice. Altogether, data from this study supports the hypothesis that susceptibility to S. mansoni infection in mice is partially dependent on the composition of the host baseline microbiota. Moreover, this study highlights the applicability of HMA mouse models for investigations of fundamental host-parasite-microbiota relationships in human helminthiases." @default.
• W3104518559 created "2020-11-23" @default.
• W3104518559 creator A5015595551 @default.
• W3104518559 creator A5023715266 @default.
• W3104518559 creator A5026207705 @default.
• W3104518559 creator A5028251855 @default.
• W3104518559 creator A5036291655 @default.
• W3104518559 creator A5040476896 @default.
• W3104518559 creator A5041987249 @default.
• W3104518559 creator A5047404265 @default.
• W3104518559 creator A5050589950 @default.
• W3104518559 creator A5061907972 @default.
• W3104518559 creator A5082240217 @default.
• W3104518559 creator A5083244058 @default.
• W3104518559 creator A5084814432 @default.
• W3104518559 creator A5089834805 @default.
• W3104518559 date "2020-11-18" @default.
• W3104518559 modified "2023-10-17" @default.
• W3104518559 title "Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models" @default.
• W3104518559 cites W1560923108 @default.
• W3104518559 cites W1566110452 @default.
• W3104518559 cites W1842473254 @default.
• W3104518559 cites W1843449358 @default.
• W3104518559 cites W1878831802 @default.
• W3104518559 cites W1881253097 @default.
• W3104518559 cites W1911175303 @default.
• W3104518559 cites W1960800379 @default.
• W3104518559 cites W1973830823 @default.
• W3104518559 cites W1991924086 @default.
• W3104518559 cites W2034285706 @default.
• W3104518559 cites W2062997740 @default.
• W3104518559 cites W2072970694 @default.
• W3104518559 cites W2094379365 @default.
• W3104518559 cites W2099053943 @default.
• W3104518559 cites W2105335085 @default.
• W3104518559 cites W2115701239 @default.
• W3104518559 cites W2122597036 @default.
• W3104518559 cites W2129178695 @default.
• W3104518559 cites W2129995681 @default.
• W3104518559 cites W2133856765 @default.
• W3104518559 cites W2148103005 @default.
• W3104518559 cites W2152428615 @default.
• W3104518559 cites W2169457151 @default.
• W3104518559 cites W2170925079 @default.
• W3104518559 cites W2345044966 @default.
• W3104518559 cites W2346423776 @default.
• W3104518559 cites W2367851449 @default.
• W3104518559 cites W2397880954 @default.
• W3104518559 cites W2401404581 @default.
• W3104518559 cites W2416704236 @default.
• W3104518559 cites W2479313159 @default.
• W3104518559 cites W2528306813 @default.
• W3104518559 cites W2528396364 @default.
• W3104518559 cites W2529812895 @default.
• W3104518559 cites W2548957578 @default.
• W3104518559 cites W2593928562 @default.
• W3104518559 cites W2599453585 @default.
• W3104518559 cites W2599697077 @default.
• W3104518559 cites W2613750778 @default.
• W3104518559 cites W2744275177 @default.
• W3104518559 cites W2773643620 @default.
• W3104518559 cites W2784164089 @default.
• W3104518559 cites W2792514364 @default.
• W3104518559 cites W2803574693 @default.
• W3104518559 cites W2806903382 @default.
• W3104518559 cites W2808386728 @default.
• W3104518559 cites W2808760864 @default.
• W3104518559 cites W2810832871 @default.
• W3104518559 cites W2883544426 @default.
• W3104518559 cites W2885535623 @default.
• W3104518559 cites W2887264357 @default.
• W3104518559 cites W2899391538 @default.
• W3104518559 cites W2900158560 @default.
• W3104518559 cites W2911165017 @default.
• W3104518559 cites W2911475499 @default.
• W3104518559 cites W2921966151 @default.
• W3104518559 cites W2945393963 @default.
• W3104518559 cites W2949302478 @default.
• W3104518559 cites W2972930822 @default.
• W3104518559 cites W2974241093 @default.
• W3104518559 cites W2976182433 @default.
• W3104518559 cites W2980738066 @default.
• W3104518559 cites W2997316861 @default.
• W3104518559 cites W2999633217 @default.
• W3104518559 cites W3007511533 @default.
• W3104518559 cites W3014945132 @default.
• W3104518559 cites W3019117562 @default.
• W3104518559 cites W4211093028 @default.
• W3104518559 doi "https://doi.org/10.3389/fimmu.2020.593838" @default.
• W3104518559 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7718013" @default.
• W3104518559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33329584" @default.
• W3104518559 hasPublicationYear "2020" @default.
• W3104518559 type Work @default.
• W3104518559 sameAs 3104518559 @default.
• W3104518559 citedByCount "18" @default.
• W3104518559 countsByYear W31045185592020 @default.
• W3104518559 countsByYear W31045185592021 @default.
• W3104518559 countsByYear W31045185592022 @default.
• W3104518559 countsByYear W31045185592023 @default.
• W3104518559 crossrefType "journal-article" @default.

• next