FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104558324> ?p ?o ?g. }

• W3104558324 abstract "ABSTRACT Different fasting regimens are known to promote health, mitigate chronic immunological disorders, and improve age-related pathophysiological parameters in animals and humans. Indeed, several clinical trials are currently ongoing using fasting as a potential therapy for a wide range of conditions. Fasting alters metabolism by acting as a reset for energy homeostasis. However, the molecular mechanisms underlying the beneficial effects of short-term fasting (STF) are still not well understood, particularly at the systems or multi-organ level. Here, we investigated the dynamic gene expression patterns associated with six periods of STF in nine different mouse organs. We cataloged the transcriptional dynamics within and between organs during STF and discovered differential temporal effects of STF among organs. Using gene ontology enrichment analysis, we identified an organ network sharing 37 common biological pathways perturbed by STF. This network incorporates the brain, liver, interscapular brown adipose tissue, and posterior-subcutaneous white adipose tissue, hence we named it the brain-liver-fats organ network. Using Reactome pathways analysis, we identified the immune system, dominated by T cell regulation processes, as a central and prominent target of systemic modulations during STF in this organ network. The changes we identified in specific immune components point to the priming of adaptive immunity and parallel the fine-tuning of innate immune signaling. Our study provides a comprehensive multi-organ transcriptomic profiling of mice subjected to multiple periods of STF, and adds new insights into the molecular modulators involved in the systemic immuno-transcriptomic changes that occur during short-term energy loss." @default.
• W3104558324 created "2020-11-23" @default.
• W3104558324 creator A5005509086 @default.
• W3104558324 creator A5015101639 @default.
• W3104558324 creator A5018243633 @default.
• W3104558324 creator A5022563979 @default.
• W3104558324 creator A5026581291 @default.
• W3104558324 creator A5030691366 @default.
• W3104558324 creator A5044959012 @default.
• W3104558324 creator A5048393700 @default.
• W3104558324 creator A5053382020 @default.
• W3104558324 creator A5057040591 @default.
• W3104558324 creator A5059565805 @default.
• W3104558324 creator A5077404140 @default.
• W3104558324 date "2020-04-05" @default.
• W3104558324 modified "2023-10-16" @default.
• W3104558324 title "Differential regulation of the immune system in a brain-liver-fats organ network during short term fasting" @default.
• W3104558324 cites W1518614040 @default.
• W3104558324 cites W1925793145 @default.
• W3104558324 cites W1954113541 @default.
• W3104558324 cites W1969353942 @default.
• W3104558324 cites W1969896761 @default.
• W3104558324 cites W1980853278 @default.
• W3104558324 cites W1986113553 @default.
• W3104558324 cites W1987894065 @default.
• W3104558324 cites W1988409463 @default.
• W3104558324 cites W1988889477 @default.
• W3104558324 cites W1995217137 @default.
• W3104558324 cites W1999249055 @default.
• W3104558324 cites W2005408869 @default.
• W3104558324 cites W2021651500 @default.
• W3104558324 cites W2035618305 @default.
• W3104558324 cites W2037043502 @default.
• W3104558324 cites W2052685738 @default.
• W3104558324 cites W2057421161 @default.
• W3104558324 cites W2058715880 @default.
• W3104558324 cites W2064173000 @default.
• W3104558324 cites W2069048337 @default.
• W3104558324 cites W2083555035 @default.
• W3104558324 cites W2085871516 @default.
• W3104558324 cites W2087406415 @default.
• W3104558324 cites W2088216132 @default.
• W3104558324 cites W2096150327 @default.
• W3104558324 cites W2096373458 @default.
• W3104558324 cites W2100761975 @default.
• W3104558324 cites W2100980426 @default.
• W3104558324 cites W2106745402 @default.
• W3104558324 cites W2114836473 @default.
• W3104558324 cites W2118308152 @default.
• W3104558324 cites W2126271200 @default.
• W3104558324 cites W2130410032 @default.
• W3104558324 cites W2133465414 @default.
• W3104558324 cites W2137586531 @default.
• W3104558324 cites W2140729960 @default.
• W3104558324 cites W2142122266 @default.
• W3104558324 cites W2145697808 @default.
• W3104558324 cites W2158261276 @default.
• W3104558324 cites W2158537778 @default.
• W3104558324 cites W2159675211 @default.
• W3104558324 cites W2162955850 @default.
• W3104558324 cites W2164683872 @default.
• W3104558324 cites W2165298215 @default.
• W3104558324 cites W2166492500 @default.
• W3104558324 cites W2169589032 @default.
• W3104558324 cites W2262790322 @default.
• W3104558324 cites W2347141677 @default.
• W3104558324 cites W2401156097 @default.
• W3104558324 cites W2440558121 @default.
• W3104558324 cites W2460546060 @default.
• W3104558324 cites W2490960385 @default.
• W3104558324 cites W2542468576 @default.
• W3104558324 cites W2566710076 @default.
• W3104558324 cites W2569953329 @default.
• W3104558324 cites W2593423817 @default.
• W3104558324 cites W2606440857 @default.
• W3104558324 cites W2611627571 @default.
• W3104558324 cites W2620293226 @default.
• W3104558324 cites W2626990662 @default.
• W3104558324 cites W2744845601 @default.
• W3104558324 cites W2762158227 @default.
• W3104558324 cites W2762506271 @default.
• W3104558324 cites W2766758542 @default.
• W3104558324 cites W2767176792 @default.
• W3104558324 cites W2788772427 @default.
• W3104558324 cites W2788781113 @default.
• W3104558324 cites W2793266102 @default.
• W3104558324 cites W2800658350 @default.
• W3104558324 cites W2800775048 @default.
• W3104558324 cites W2800808913 @default.
• W3104558324 cites W2806113892 @default.
• W3104558324 cites W2806584002 @default.
• W3104558324 cites W2885515523 @default.
• W3104558324 cites W2891690844 @default.
• W3104558324 cites W2900255713 @default.
• W3104558324 cites W2905460695 @default.
• W3104558324 cites W2924319297 @default.
• W3104558324 cites W2969352266 @default.
• W3104558324 cites W2969352988 @default.
• W3104558324 cites W2969456171 @default.
• W3104558324 cites W2969628442 @default.

• next