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- W3104657103 endingPage "115875" @default.
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- W3104657103 abstract "NEDDylation is a post-translational modification of a protein, which transfers Ubiquitin like protein NEDD8 (Neuronal Precursor Cell-expressed Developmentally Down-regulated Protein 8) to the lysine residue of the product through a three-stage enzymatic reaction, and widely regulates many biological processes, such as cell cycle signal transduction and immune recognition. In the past ten years, we have witnessed tremendous progress in the study of protein ubiquitination modification, from modification mechanisms to drug development. Which suggests that inhibition of NEDDylation is an effective way to inhibit tumor. A variety of biological detection methods have been developed during the development of the inhibitor. In this review, we briefly introduced the modification process and substrates of NEDDylation, and discussed detection methods of NEDDylation activity in detail. This review will provide an up-to-date and comprehensive review of the methods for detecting NEDDylation activity that will contribute to NEDDylation inhibitor development." @default.
- W3104657103 created "2020-11-23" @default.
- W3104657103 creator A5009613920 @default.
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- W3104657103 creator A5072406539 @default.
- W3104657103 creator A5082212272 @default.
- W3104657103 creator A5083275992 @default.
- W3104657103 date "2021-01-01" @default.
- W3104657103 modified "2023-10-06" @default.
- W3104657103 title "Review of NEDDylation inhibition activity detection methods" @default.
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