Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104678081> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W3104678081 abstract "Previously, we identified a multigene signature related with survival of patients with high-grade serous ovarian cancer (OC).1 2 Among differentially expressed genes was Integrin beta-like 1 (ITGBL1). Our functional studies revealed that ITGBL1 overexpression in ovarian cancer cells resulted in increased invasiveness,3 migration rate, and chemoresistance, while decreased adhesiveness4 and no change in proliferation rate.5 Later it appeared, that 4 mRNA variants of ITGBL1 may exist. The aim of our this study was to evaluate the presence of these variants in several wild-type OC cell lines, including OVPA8 established by our group.6 Next, we analyzed cells with ITGBL1 construct (OAW42-ITGBL1 and SKOV3-ITGBL1) and with an empty PLNCX2 vector. Variant-1 (containing all exons) was prevalent in these cell lines which expressed ITGBL1 (ES2, OVPA8, SKOV3-ITGBL1, and OAW42-ITGBL1). Variant-2 was very low or absent in all cell lines. Variant-3 was present in significant amounts only in OAW42-ITGBL1 and ES2 cells, while variant-4 exclusively in ES2. ES2 cell line was the only expressing all 4 variants. In summary: variant-1 is prevalent and variant-3 is second detectable, both in wild-type OC cells with natural ITGBL1 expression and in OAW42 and SKOV3 cells with ITGBL1 construct. These results confirm the validity of our experimental model and our previous conclusions concerning the influence of ITGBL1 on OC cells phenotype. References Lisowska, et al. (2014), DOI:10.3389/fonc.2014.00006 Lisowska, et al. (2016), DOI:10.1007/s00432-016-2147-y Cortez, et al. (2018), DOI:10.1093/annonc/mdy268.036 Cortez, et al. (2016), DOI:10.1097/01.IGC.0000503327.50238.5c Cortez, et al. (2017), DOI:10.1097/01.IGC.0000527296.86225.87 Tudrej, et al. (2018), DOI:10.3390/ijms19072080" @default.
- W3104678081 created "2020-11-23" @default.
- W3104678081 creator A5004739296 @default.
- W3104678081 creator A5014286562 @default.
- W3104678081 creator A5030296306 @default.
- W3104678081 creator A5088327829 @default.
- W3104678081 date "2020-11-01" @default.
- W3104678081 modified "2023-10-01" @default.
- W3104678081 title "69 Detection of ITGBL1 mRNA isoforms in ovarian cancer cells" @default.
- W3104678081 doi "https://doi.org/10.1136/ijgc-2020-igcs.65" @default.
- W3104678081 hasPublicationYear "2020" @default.
- W3104678081 type Work @default.
- W3104678081 sameAs 3104678081 @default.
- W3104678081 citedByCount "0" @default.
- W3104678081 crossrefType "proceedings-article" @default.
- W3104678081 hasAuthorship W3104678081A5004739296 @default.
- W3104678081 hasAuthorship W3104678081A5014286562 @default.
- W3104678081 hasAuthorship W3104678081A5030296306 @default.
- W3104678081 hasAuthorship W3104678081A5088327829 @default.
- W3104678081 hasBestOaLocation W31046780811 @default.
- W3104678081 hasConcept C104317684 @default.
- W3104678081 hasConcept C105580179 @default.
- W3104678081 hasConcept C121608353 @default.
- W3104678081 hasConcept C127716648 @default.
- W3104678081 hasConcept C150173356 @default.
- W3104678081 hasConcept C153911025 @default.
- W3104678081 hasConcept C2780427987 @default.
- W3104678081 hasConcept C36823959 @default.
- W3104678081 hasConcept C502942594 @default.
- W3104678081 hasConcept C53345823 @default.
- W3104678081 hasConcept C54355233 @default.
- W3104678081 hasConcept C55493867 @default.
- W3104678081 hasConcept C81885089 @default.
- W3104678081 hasConcept C86803240 @default.
- W3104678081 hasConceptScore W3104678081C104317684 @default.
- W3104678081 hasConceptScore W3104678081C105580179 @default.
- W3104678081 hasConceptScore W3104678081C121608353 @default.
- W3104678081 hasConceptScore W3104678081C127716648 @default.
- W3104678081 hasConceptScore W3104678081C150173356 @default.
- W3104678081 hasConceptScore W3104678081C153911025 @default.
- W3104678081 hasConceptScore W3104678081C2780427987 @default.
- W3104678081 hasConceptScore W3104678081C36823959 @default.
- W3104678081 hasConceptScore W3104678081C502942594 @default.
- W3104678081 hasConceptScore W3104678081C53345823 @default.
- W3104678081 hasConceptScore W3104678081C54355233 @default.
- W3104678081 hasConceptScore W3104678081C55493867 @default.
- W3104678081 hasConceptScore W3104678081C81885089 @default.
- W3104678081 hasConceptScore W3104678081C86803240 @default.
- W3104678081 hasLocation W31046780811 @default.
- W3104678081 hasOpenAccess W3104678081 @default.
- W3104678081 hasPrimaryLocation W31046780811 @default.
- W3104678081 hasRelatedWork W17901105 @default.
- W3104678081 hasRelatedWork W2068184 @default.
- W3104678081 hasRelatedWork W27573832 @default.
- W3104678081 hasRelatedWork W31503111 @default.
- W3104678081 hasRelatedWork W32802486 @default.
- W3104678081 hasRelatedWork W36591980 @default.
- W3104678081 hasRelatedWork W40090185 @default.
- W3104678081 hasRelatedWork W40756818 @default.
- W3104678081 hasRelatedWork W7236413 @default.
- W3104678081 hasRelatedWork W731244 @default.
- W3104678081 isParatext "false" @default.
- W3104678081 isRetracted "false" @default.
- W3104678081 magId "3104678081" @default.
- W3104678081 workType "article" @default.