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• W3104718323 abstract "The nucleus of the solitary tract (NTS) is critical for the central integration of signals from visceral organs and contains preproglucagon (PPG) neurons, which express leptin receptors in the mouse and send direct projections to the paraventricular nucleus of the hypothalamus (PVH). Here, we visualized projections of PPG neurons in leptin-deficient Lep ob/ob mice and found that projections from PPG neurons are elevated compared with controls, and PPG projections were normalized by targeted rescue of leptin receptors in LepRb TB/TB mice, which lack functional neuronal leptin receptors. Moreover, Lep ob/ob and LepRb TB/TB mice displayed increased levels of neuronal activation in the PVH following vagal stimulation, and whole-cell patch recordings of GLP-1 receptor-expressing PVH neurons revealed enhanced excitatory neurotransmission, suggesting that leptin acts cell autonomously to suppress representation of excitatory afferents from PPG neurons, thereby diminishing the impact of visceral sensory information on GLP-1 receptor-expressing neurons in the PVH." @default.
• W3104718323 created "2020-11-23" @default.
• W3104718323 creator A5030904270 @default.
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• W3104718323 date "2020-11-18" @default.
• W3104718323 modified "2023-10-14" @default.
• W3104718323 title "Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus" @default.
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• W3104718323 doi "https://doi.org/10.7554/elife.59857" @default.
• W3104718323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7673779" @default.
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• W3104718323 hasPublicationYear "2020" @default.
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