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- W3104777419 abstract "Functional symptoms caused by esophageal motor disorders are very common. The esophageal transit scintigraphy has been done using liquid and solid meals to understand pathophysiology of esophageal motor disorders better. The present study was aimed to develop and standardize a stable and easily acceptable radioactive semisolid meal for esophageal transit scintigraphy. Semisolid jelly incorporated with Tc-99m sulphur colloid was prepared from the commercially available edible jelly powder-containing gelatin. The tracer stability was investigated by in-vitro method up to 4 hours to test the affinity of tracer and mechanical stability of semisolid meal. The amount of semisolid meal per bolus was also standardized in relation to ease of swallowing and free passage of it through whole of esophagus. The additional objective was to establish the normal esophageal transit scintigraphic parameters. Materials and methods: A total of 31 normal volunteers were studied. The esophageal transit scintigraphy was performed in supine and sitting positions thrice using single bolus of 2 gm semisolid jelly containing 7.4 MBq (200uCi) of tracer for the acquisition period of 192 seconds. The esophageal emptying time for 50% (T50) and for 90% (T90) were calculated by computer analysis in addition to generation of condensed dynamic images. Results: The 50% and 90% whole esophageal emptying time are given below in the table in sitting and supine positions respectively.(P<0.05). Conclusions: Condensed dynamic images revealed normal transit pattern without delay or stasis and fragmentation of bolus through the esophagus. The stability and homogeneity of tracer in the semisolid meal provided a simple and reliable method for carrying out esophageal transit scintigraphy. It was found that this bolus was well accepted by normal volunteers and values obtained were well within the acceptable range. Thus we established the normal values in our laboratory and also standardized a semisolid meal with its suitability for routine clinical use. (authors)" @default.
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- W3104777419 date "2004-07-01" @default.
- W3104777419 modified "2023-09-27" @default.
- W3104777419 title "Esophageal transit scintigraphy in healthy volunteers using TC-99M sulphur colloid semisolid jelly" @default.
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