FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104785443> ?p ?o ?g. }

• W3104785443 endingPage "387" @default.
• W3104785443 startingPage "380" @default.
• W3104785443 abstract "Bile acid malabsorption is common in microscopic colitis, irritable bowel syndrome with diarrhea, and inflammatory bowel disease. We investigated the diagnostic accuracy of 7-alfa-hydroxy-4-cholesten-3-one and compared it with fibroblast growth factor-19 as biomarkers for bile acid malabsorption.We enrolled consecutively 109 chronic diarrhea patients with standard laboratory tests, fecal calprotectin, and endoscopy separated into six groups: n = 30 with active inflammatory bowel disease, n = 21 with inflammatory bowel disease in remission reporting >3 bowel movements per day, n = 21 with inflammatory bowel disease after surgery, n = 23 with irritable bowel syndrome with diarrhea, n = 14 with microscopic colitis and 11 healthy subjects (controls). We defined bile acid malabsorption as >3 bowel movements and lower fibroblast growth factor-19 (<60 pg/ml).Median levels of 7-alfa-hydroxy-4-cholesten-3-one in inflammatory bowel disease active were 53.1 ng/ml, inflammatory bowel disease remission were 52.2 ng/ml, inflammatory bowel disease after surgery were 85.7 ng/ml, irritable bowel syndrome with diarrhea were 7.5 ng/ml, microscopic colitis were 69.3 ng/ml, and healthy controls were 3.7 ng/ml. We estimate a 7-alfa-hydroxy-4-cholesten-3-one cutoff of 48.9 ng/ml with 82.6% sensitivity and 84.3% specificity for detecting bile acid malabsorption. Both 7-alfa-hydroxy-4-cholesten-3-one >48.9 ng/ml and fibroblast growth factor-19 (<60 pg/ml) were found in 52% of the patients, compared with those 8% of patients below this 7-alfa-hydroxy-4-cholesten-3-one cutoff (P < 0.001). Serum 7-alfa-hydroxy-4-cholesten-3-one correlated with the number of bowel movements/day (r = -0.709; P < 0.001) and correlated inversely with fibroblast growth factor-19 (r = -0.741; P < 0.001).Serum 7-alfa-hydroxy-4-cholesten-3-one above 48.9 ng/ml and fibroblast growth factor-19 below 60 pg/ml identify patients with diarrhea likely attributable to bile acid malabsorption with high diagnostic accuracy and they can be used as screening biomarkers for bile acid malabsorption in microscopic colitis and inflammatory bowel disease." @default.
• W3104785443 created "2020-11-23" @default.
• W3104785443 creator A5004194610 @default.
• W3104785443 creator A5017174033 @default.
• W3104785443 creator A5043230834 @default.
• W3104785443 creator A5049750513 @default.
• W3104785443 creator A5072390356 @default.
• W3104785443 date "2020-11-10" @default.
• W3104785443 modified "2023-09-27" @default.
• W3104785443 title "Serum 7-alfa-hydroxy-4-cholesten-3-one and fibroblast growth factor-19 as biomarkers diagnosing bile acid malabsorption in microscopic colitis and inflammatory bowel disease" @default.
• W3104785443 cites W101051652 @default.
• W3104785443 cites W1559606798 @default.
• W3104785443 cites W1569339044 @default.
• W3104785443 cites W1591931848 @default.
• W3104785443 cites W1992706585 @default.
• W3104785443 cites W2000891332 @default.
• W3104785443 cites W2030620017 @default.
• W3104785443 cites W2040038239 @default.
• W3104785443 cites W2042707876 @default.
• W3104785443 cites W2048453651 @default.
• W3104785443 cites W2052082457 @default.
• W3104785443 cites W2054983288 @default.
• W3104785443 cites W2077936949 @default.
• W3104785443 cites W2092469452 @default.
• W3104785443 cites W2092866485 @default.
• W3104785443 cites W2100311096 @default.
• W3104785443 cites W2115162513 @default.
• W3104785443 cites W2129559491 @default.
• W3104785443 cites W2141060099 @default.
• W3104785443 cites W2142752326 @default.
• W3104785443 cites W2164824799 @default.
• W3104785443 cites W2279744703 @default.
• W3104785443 cites W2344997643 @default.
• W3104785443 cites W2733533247 @default.
• W3104785443 cites W2743526837 @default.
• W3104785443 cites W2789438444 @default.
• W3104785443 cites W2891495287 @default.
• W3104785443 cites W2901362128 @default.
• W3104785443 cites W99513707 @default.
• W3104785443 doi "https://doi.org/10.1097/meg.0000000000001925" @default.
• W3104785443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33177381" @default.
• W3104785443 hasPublicationYear "2020" @default.
• W3104785443 type Work @default.
• W3104785443 sameAs 3104785443 @default.
• W3104785443 citedByCount "3" @default.
• W3104785443 countsByYear W31047854432022 @default.
• W3104785443 countsByYear W31047854432023 @default.
• W3104785443 crossrefType "journal-article" @default.
• W3104785443 hasAuthorship W3104785443A5004194610 @default.
• W3104785443 hasAuthorship W3104785443A5017174033 @default.
• W3104785443 hasAuthorship W3104785443A5043230834 @default.
• W3104785443 hasAuthorship W3104785443A5049750513 @default.
• W3104785443 hasAuthorship W3104785443A5072390356 @default.
• W3104785443 hasConcept C126322002 @default.
• W3104785443 hasConcept C2776839343 @default.
• W3104785443 hasConcept C2778260677 @default.
• W3104785443 hasConcept C2778271842 @default.
• W3104785443 hasConcept C2778292693 @default.
• W3104785443 hasConcept C2778561856 @default.
• W3104785443 hasConcept C2779134260 @default.
• W3104785443 hasConcept C2779802037 @default.
• W3104785443 hasConcept C2780439177 @default.
• W3104785443 hasConcept C71924100 @default.
• W3104785443 hasConcept C90924648 @default.
• W3104785443 hasConceptScore W3104785443C126322002 @default.
• W3104785443 hasConceptScore W3104785443C2776839343 @default.
• W3104785443 hasConceptScore W3104785443C2778260677 @default.
• W3104785443 hasConceptScore W3104785443C2778271842 @default.
• W3104785443 hasConceptScore W3104785443C2778292693 @default.
• W3104785443 hasConceptScore W3104785443C2778561856 @default.
• W3104785443 hasConceptScore W3104785443C2779134260 @default.
• W3104785443 hasConceptScore W3104785443C2779802037 @default.
• W3104785443 hasConceptScore W3104785443C2780439177 @default.
• W3104785443 hasConceptScore W3104785443C71924100 @default.
• W3104785443 hasConceptScore W3104785443C90924648 @default.
• W3104785443 hasIssue "3" @default.
• W3104785443 hasLocation W31047854431 @default.
• W3104785443 hasLocation W31047854432 @default.
• W3104785443 hasOpenAccess W3104785443 @default.
• W3104785443 hasPrimaryLocation W31047854431 @default.
• W3104785443 hasRelatedWork W1490231490 @default.
• W3104785443 hasRelatedWork W1989813246 @default.
• W3104785443 hasRelatedWork W2008450022 @default.
• W3104785443 hasRelatedWork W2394887945 @default.
• W3104785443 hasRelatedWork W2549880305 @default.
• W3104785443 hasRelatedWork W2606197649 @default.
• W3104785443 hasRelatedWork W2999237140 @default.
• W3104785443 hasRelatedWork W3104785443 @default.
• W3104785443 hasRelatedWork W4243561384 @default.
• W3104785443 hasRelatedWork W4323035025 @default.
• W3104785443 hasVolume "33" @default.
• W3104785443 isParatext "false" @default.
• W3104785443 isRetracted "false" @default.
• W3104785443 magId "3104785443" @default.
• W3104785443 workType "article" @default.