Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104815548> ?p ?o ?g. }
- W3104815548 abstract "ABSTRACT Taste receptor cells use multiple signaling pathways to detect chemicals in potential food items. These cells are functionally grouped into different types: Type I cells act as support cells and have glial-like properties; Type II cells detect bitter, sweet, and umami taste stimuli; and Type III cells detect sour and salty stimuli. We have identified a new population of taste cells that are broadly tuned to multiple taste stimuli including bitter, sweet, sour and umami. The goal of this study was to characterize these broadly responsive (BR) taste cells. We used an IP3R3-KO mouse (does not release calcium (Ca 2+ ) from Type II cells when stimulated with bitter, sweet or umami stimuli) to characterize the BR cells without any potentially confounding input from Type II cells. Using live cell Ca 2+ imaging in isolated taste cells from the IP 3 R3-KO mouse, we found that BR cells are a subset of Type III cells that respond to sour stimuli but also use a PLCβ3 signaling pathway to respond to bitter, sweet and umami stimuli. Unlike Type II cells, individual BR cells are broadly tuned and respond to multiple stimuli across different taste modalities. Live cell imaging in a PLCβ3-KO mouse confirmed that BR cells use a PLCβ3 signaling pathway to generate Ca 2+ signals to bitter, sweet and umami stimuli. Analysis of c-Fos activity in the nucleus of the solitary tract (NTS) and short term behavioral assays revealed that BR cells make significant contributions to taste." @default.
- W3104815548 created "2020-11-23" @default.
- W3104815548 creator A5007030180 @default.
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- W3104815548 date "2019-06-05" @default.
- W3104815548 modified "2023-10-16" @default.
- W3104815548 title "A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli" @default.
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