Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104820797> ?p ?o ?g. }
- W3104820797 endingPage "918" @default.
- W3104820797 startingPage "905" @default.
- W3104820797 abstract "Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a life-saving procedure used for the treatment of selected hematological malignancies, inborn errors of metabolism, and bone marrow failures. The role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against infection. However, recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered functions. Accordingly, neutrophils are emerging as highly versatile cells that are able to acquire different, often opposite, functional capacities depending on the microenvironment and their differentiation status. Herein, we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT, from the hematopoietic stem cell (HSC) mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC infusion. We also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versus-host disease (GVHD) prophylaxis. Finally, the potential involvement of neutrophils in alloHSCT-related complications, such as transplant-associated thrombotic microangiopathy (TA-TMA), acute and chronic GVHD, and cytomegalovirus (CMV) reactivation, is also discussed. Based on the data reviewed herein, the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial role. However, much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT." @default.
- W3104820797 created "2020-11-23" @default.
- W3104820797 creator A5005421553 @default.
- W3104820797 creator A5066461145 @default.
- W3104820797 date "2020-11-17" @default.
- W3104820797 modified "2023-10-16" @default.
- W3104820797 title "Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation" @default.
- W3104820797 cites W1552120844 @default.
- W3104820797 cites W1559130830 @default.
- W3104820797 cites W1564279536 @default.
- W3104820797 cites W1614726407 @default.
- W3104820797 cites W1755350398 @default.
- W3104820797 cites W1772965091 @default.
- W3104820797 cites W1791860955 @default.
- W3104820797 cites W1864128415 @default.
- W3104820797 cites W1966542907 @default.
- W3104820797 cites W1970909450 @default.
- W3104820797 cites W1972330653 @default.
- W3104820797 cites W1979027206 @default.
- W3104820797 cites W1979431346 @default.
- W3104820797 cites W1979952143 @default.
- W3104820797 cites W1981086130 @default.
- W3104820797 cites W1986410924 @default.
- W3104820797 cites W1987984407 @default.
- W3104820797 cites W1998925209 @default.
- W3104820797 cites W2004814040 @default.
- W3104820797 cites W2005587987 @default.
- W3104820797 cites W2009506948 @default.
- W3104820797 cites W2010391415 @default.
- W3104820797 cites W2010942909 @default.
- W3104820797 cites W2011196153 @default.
- W3104820797 cites W2014466662 @default.
- W3104820797 cites W2016420042 @default.
- W3104820797 cites W2017338571 @default.
- W3104820797 cites W2019916852 @default.
- W3104820797 cites W2020327043 @default.
- W3104820797 cites W2021827061 @default.
- W3104820797 cites W2030383845 @default.
- W3104820797 cites W2033282254 @default.
- W3104820797 cites W2036145275 @default.
- W3104820797 cites W2037265282 @default.
- W3104820797 cites W2038908080 @default.
- W3104820797 cites W2038952117 @default.
- W3104820797 cites W2039334806 @default.
- W3104820797 cites W2042927644 @default.
- W3104820797 cites W2050014694 @default.
- W3104820797 cites W2054246680 @default.
- W3104820797 cites W2060383888 @default.
- W3104820797 cites W2060756924 @default.
- W3104820797 cites W2064693934 @default.
- W3104820797 cites W2066667193 @default.
- W3104820797 cites W2067977262 @default.
- W3104820797 cites W2072693747 @default.
- W3104820797 cites W2072706091 @default.
- W3104820797 cites W2074356513 @default.
- W3104820797 cites W2079350855 @default.
- W3104820797 cites W2082413924 @default.
- W3104820797 cites W2083188164 @default.
- W3104820797 cites W2084015186 @default.
- W3104820797 cites W2086342402 @default.
- W3104820797 cites W2087166943 @default.
- W3104820797 cites W2095078549 @default.
- W3104820797 cites W2095579581 @default.
- W3104820797 cites W2095940261 @default.
- W3104820797 cites W2099356583 @default.
- W3104820797 cites W2099604050 @default.
- W3104820797 cites W2101360897 @default.
- W3104820797 cites W2104934425 @default.
- W3104820797 cites W2109293981 @default.
- W3104820797 cites W2114805956 @default.
- W3104820797 cites W2117034501 @default.
- W3104820797 cites W2117803220 @default.
- W3104820797 cites W2119526236 @default.
- W3104820797 cites W2120418701 @default.
- W3104820797 cites W2132132140 @default.
- W3104820797 cites W2134401635 @default.
- W3104820797 cites W2135721651 @default.
- W3104820797 cites W2137949504 @default.
- W3104820797 cites W2144456609 @default.
- W3104820797 cites W2149476900 @default.
- W3104820797 cites W2151279610 @default.
- W3104820797 cites W2152899800 @default.
- W3104820797 cites W2156038438 @default.
- W3104820797 cites W2157973267 @default.
- W3104820797 cites W2159913536 @default.
- W3104820797 cites W2160879893 @default.
- W3104820797 cites W2165823706 @default.
- W3104820797 cites W2168205651 @default.
- W3104820797 cites W2172191543 @default.
- W3104820797 cites W2194347198 @default.
- W3104820797 cites W2210729715 @default.
- W3104820797 cites W2232371609 @default.
- W3104820797 cites W2301960044 @default.
- W3104820797 cites W2321365245 @default.
- W3104820797 cites W2325356223 @default.
- W3104820797 cites W2327619666 @default.
- W3104820797 cites W2336513938 @default.
- W3104820797 cites W2339213442 @default.