Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104937029> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3104937029 endingPage "319" @default.
- W3104937029 startingPage "311" @default.
- W3104937029 abstract "• The alkaloid extract of Voacanga africana seeds was the main cytotoxic component. • Compound 1 obtained from the alkaloid extract was a new compound. • Compound 6 (tabersonine) had the best cytotoxic activity and broad spectrum cytotoxicity. • The cytotoxic activity of tabersonine may be attributed to the induction of apoptosis. • The compound 6 (tabersonine) could be considered as a potential anti-tumor agent. Voacanga africana is a medicinal tree used in Ghana in West Africa for treatment of various diseases. Using MTT assay-guided separation, 6 compounds were isolated and identified. Compound 1 was a new compound, and the rest 5 compounds were 3-oxo-tabersonine ( 2 ), 3α- acetonylvoafrine B ( 3 ), lochnericine ( 4 ), 17,18-dehydrovincamine ( 5 ) and tabersonine ( 6 ). Amongst these compounds, tabersonine exhibited a remarkable cytotoxic activity and the IC 50 value of tabersonine on 10 types of human cancer cell lines range from 4.8 ± 0.4 µg/mL to 22.5 ± 1.4 µg/mL. The cytotoxicity of tabersonine may be through inducing apoptosis. In conclusion, this study is the first report about the isolation and evaluation of anti-tumor components in Voacanga africana seeds. From these results, the alkaloid compound tabersonine could be considered as a potential anti-tumor agent." @default.
- W3104937029 created "2020-11-23" @default.
- W3104937029 creator A5001619773 @default.
- W3104937029 creator A5007509223 @default.
- W3104937029 creator A5018951449 @default.
- W3104937029 creator A5024129575 @default.
- W3104937029 creator A5027937292 @default.
- W3104937029 creator A5031455285 @default.
- W3104937029 creator A5031503034 @default.
- W3104937029 creator A5032383307 @default.
- W3104937029 creator A5034755663 @default.
- W3104937029 creator A5071659144 @default.
- W3104937029 creator A5072361648 @default.
- W3104937029 creator A5087286560 @default.
- W3104937029 date "2021-03-01" @default.
- W3104937029 modified "2023-10-13" @default.
- W3104937029 title "Cytotoxic active ingredients from the seeds of Voacanga africana" @default.
- W3104937029 cites W1513236596 @default.
- W3104937029 cites W1798059094 @default.
- W3104937029 cites W1843785601 @default.
- W3104937029 cites W1966423974 @default.
- W3104937029 cites W1984943870 @default.
- W3104937029 cites W1994069053 @default.
- W3104937029 cites W2002582103 @default.
- W3104937029 cites W2005490366 @default.
- W3104937029 cites W2034058708 @default.
- W3104937029 cites W2034357559 @default.
- W3104937029 cites W2035575975 @default.
- W3104937029 cites W2057745527 @default.
- W3104937029 cites W2062613670 @default.
- W3104937029 cites W2071567017 @default.
- W3104937029 cites W2077064004 @default.
- W3104937029 cites W2083351231 @default.
- W3104937029 cites W2121119058 @default.
- W3104937029 cites W2123229444 @default.
- W3104937029 cites W2138258870 @default.
- W3104937029 cites W2167106423 @default.
- W3104937029 cites W2316104689 @default.
- W3104937029 cites W2611355648 @default.
- W3104937029 cites W2616069486 @default.
- W3104937029 cites W2744630544 @default.
- W3104937029 cites W2801210045 @default.
- W3104937029 cites W2809256520 @default.
- W3104937029 doi "https://doi.org/10.1016/j.sajb.2020.10.028" @default.
- W3104937029 hasPublicationYear "2021" @default.
- W3104937029 type Work @default.
- W3104937029 sameAs 3104937029 @default.
- W3104937029 citedByCount "4" @default.
- W3104937029 countsByYear W31049370292022 @default.
- W3104937029 countsByYear W31049370292023 @default.
- W3104937029 crossrefType "journal-article" @default.
- W3104937029 hasAuthorship W3104937029A5001619773 @default.
- W3104937029 hasAuthorship W3104937029A5007509223 @default.
- W3104937029 hasAuthorship W3104937029A5018951449 @default.
- W3104937029 hasAuthorship W3104937029A5024129575 @default.
- W3104937029 hasAuthorship W3104937029A5027937292 @default.
- W3104937029 hasAuthorship W3104937029A5031455285 @default.
- W3104937029 hasAuthorship W3104937029A5031503034 @default.
- W3104937029 hasAuthorship W3104937029A5032383307 @default.
- W3104937029 hasAuthorship W3104937029A5034755663 @default.
- W3104937029 hasAuthorship W3104937029A5071659144 @default.
- W3104937029 hasAuthorship W3104937029A5072361648 @default.
- W3104937029 hasAuthorship W3104937029A5087286560 @default.
- W3104937029 hasBestOaLocation W31049370291 @default.
- W3104937029 hasConcept C154317977 @default.
- W3104937029 hasConcept C202751555 @default.
- W3104937029 hasConcept C54355233 @default.
- W3104937029 hasConcept C556039675 @default.
- W3104937029 hasConcept C71924100 @default.
- W3104937029 hasConcept C86803240 @default.
- W3104937029 hasConceptScore W3104937029C154317977 @default.
- W3104937029 hasConceptScore W3104937029C202751555 @default.
- W3104937029 hasConceptScore W3104937029C54355233 @default.
- W3104937029 hasConceptScore W3104937029C556039675 @default.
- W3104937029 hasConceptScore W3104937029C71924100 @default.
- W3104937029 hasConceptScore W3104937029C86803240 @default.
- W3104937029 hasFunder F4320311847 @default.
- W3104937029 hasFunder F4320321001 @default.
- W3104937029 hasLocation W31049370291 @default.
- W3104937029 hasOpenAccess W3104937029 @default.
- W3104937029 hasPrimaryLocation W31049370291 @default.
- W3104937029 hasRelatedWork W1497833379 @default.
- W3104937029 hasRelatedWork W1566368246 @default.
- W3104937029 hasRelatedWork W1964266791 @default.
- W3104937029 hasRelatedWork W2004466917 @default.
- W3104937029 hasRelatedWork W2040631670 @default.
- W3104937029 hasRelatedWork W2049624095 @default.
- W3104937029 hasRelatedWork W2110968275 @default.
- W3104937029 hasRelatedWork W2414729062 @default.
- W3104937029 hasRelatedWork W3087470930 @default.
- W3104937029 hasRelatedWork W4313313459 @default.
- W3104937029 hasVolume "137" @default.
- W3104937029 isParatext "false" @default.
- W3104937029 isRetracted "false" @default.
- W3104937029 magId "3104937029" @default.
- W3104937029 workType "article" @default.