FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3104969749> ?p ?o ?g. }

• W3104969749 abstract "ABSTRACT The prebiotic synthesis of ribonucleotides is likely to have been accompanied by the synthesis of noncanonical nucleotides including the threo-nucleotide building blocks of TNA. Here we examine the ability of activated threo-nucleotides to participate in nonenzymatic template-directed polymerization. We find that primer extension by multiple sequential threo-nucleotide monomers is strongly disfavored relative to ribo-nucleotides. Kinetic, NMR and crystallographic studies suggest that this is due in part to the slow formation of the imidazolium-bridged TNA dinucleotide intermediate in primer extension, and in part because of the greater distance between the attacking RNA primer 3’-hydroxyl and the phosphate of the incoming threo-nucleotide intermediate. Even a single activated threo-nucleotide in the presence of an activated downstream RNA oligonucleotide is added to the primer ten-fold more slowly than an activated ribonucleotide. In contrast, a single activated threo-nucleotide at the end of an RNA primer or in an RNA template results in only a modest decrease in the rate of primer extension, consistent with the minor and local structural distortions revealed by crystal structures. Our results are consistent with a model in which heterogeneous primordial oligonucleotides would, through cycles of replication, have given rise to increasingly homogeneous RNA strands." @default.
• W3104969749 created "2020-11-23" @default.
• W3104969749 creator A5023274897 @default.
• W3104969749 creator A5024210933 @default.
• W3104969749 creator A5055041085 @default.
• W3104969749 creator A5055630196 @default.
• W3104969749 creator A5063642190 @default.
• W3104969749 creator A5081890628 @default.
• W3104969749 creator A5091220608 @default.
• W3104969749 date "2020-11-17" @default.
• W3104969749 modified "2023-10-05" @default.
• W3104969749 title "Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization" @default.
• W3104969749 cites W1517927116 @default.
• W3104969749 cites W1538614659 @default.
• W3104969749 cites W1896233609 @default.
• W3104969749 cites W1986588294 @default.
• W3104969749 cites W2002632700 @default.
• W3104969749 cites W2010790220 @default.
• W3104969749 cites W2038212339 @default.
• W3104969749 cites W2038840577 @default.
• W3104969749 cites W2050533681 @default.
• W3104969749 cites W2056217407 @default.
• W3104969749 cites W2068866467 @default.
• W3104969749 cites W2075002643 @default.
• W3104969749 cites W2089644153 @default.
• W3104969749 cites W2094464276 @default.
• W3104969749 cites W2104166784 @default.
• W3104969749 cites W2114367386 @default.
• W3104969749 cites W2163341755 @default.
• W3104969749 cites W2169821755 @default.
• W3104969749 cites W2279480278 @default.
• W3104969749 cites W2467190354 @default.
• W3104969749 cites W2472372051 @default.
• W3104969749 cites W2512565170 @default.
• W3104969749 cites W2548157820 @default.
• W3104969749 cites W2583079108 @default.
• W3104969749 cites W2612376243 @default.
• W3104969749 cites W2726371753 @default.
• W3104969749 cites W2762359702 @default.
• W3104969749 cites W2763165835 @default.
• W3104969749 cites W2790554722 @default.
• W3104969749 cites W2953287427 @default.
• W3104969749 cites W2974812040 @default.
• W3104969749 cites W2978780344 @default.
• W3104969749 cites W3000148824 @default.
• W3104969749 cites W3184228035 @default.
• W3104969749 cites W4229741828 @default.
• W3104969749 doi "https://doi.org/10.1101/2020.11.17.387142" @default.
• W3104969749 hasPublicationYear "2020" @default.
• W3104969749 type Work @default.
• W3104969749 sameAs 3104969749 @default.
• W3104969749 citedByCount "0" @default.
• W3104969749 crossrefType "posted-content" @default.
• W3104969749 hasAuthorship W3104969749A5023274897 @default.
• W3104969749 hasAuthorship W3104969749A5024210933 @default.
• W3104969749 hasAuthorship W3104969749A5055041085 @default.
• W3104969749 hasAuthorship W3104969749A5055630196 @default.
• W3104969749 hasAuthorship W3104969749A5063642190 @default.
• W3104969749 hasAuthorship W3104969749A5081890628 @default.
• W3104969749 hasAuthorship W3104969749A5091220608 @default.
• W3104969749 hasBestOaLocation W31049697491 @default.
• W3104969749 hasConcept C104317684 @default.
• W3104969749 hasConcept C129312508 @default.
• W3104969749 hasConcept C178790620 @default.
• W3104969749 hasConcept C185592680 @default.
• W3104969749 hasConcept C194857396 @default.
• W3104969749 hasConcept C2777563447 @default.
• W3104969749 hasConcept C44228677 @default.
• W3104969749 hasConcept C512185932 @default.
• W3104969749 hasConcept C521977710 @default.
• W3104969749 hasConcept C552990157 @default.
• W3104969749 hasConcept C55493867 @default.
• W3104969749 hasConcept C67705224 @default.
• W3104969749 hasConcept C71240020 @default.
• W3104969749 hasConcept C98892162 @default.
• W3104969749 hasConceptScore W3104969749C104317684 @default.
• W3104969749 hasConceptScore W3104969749C129312508 @default.
• W3104969749 hasConceptScore W3104969749C178790620 @default.
• W3104969749 hasConceptScore W3104969749C185592680 @default.
• W3104969749 hasConceptScore W3104969749C194857396 @default.
• W3104969749 hasConceptScore W3104969749C2777563447 @default.
• W3104969749 hasConceptScore W3104969749C44228677 @default.
• W3104969749 hasConceptScore W3104969749C512185932 @default.
• W3104969749 hasConceptScore W3104969749C521977710 @default.
• W3104969749 hasConceptScore W3104969749C552990157 @default.
• W3104969749 hasConceptScore W3104969749C55493867 @default.
• W3104969749 hasConceptScore W3104969749C67705224 @default.
• W3104969749 hasConceptScore W3104969749C71240020 @default.
• W3104969749 hasConceptScore W3104969749C98892162 @default.
• W3104969749 hasLocation W31049697491 @default.
• W3104969749 hasLocation W31049697492 @default.
• W3104969749 hasLocation W31049697493 @default.
• W3104969749 hasLocation W31049697494 @default.
• W3104969749 hasOpenAccess W3104969749 @default.
• W3104969749 hasPrimaryLocation W31049697491 @default.
• W3104969749 hasRelatedWork W22034794 @default.
• W3104969749 hasRelatedWork W22589680 @default.
• W3104969749 hasRelatedWork W24056667 @default.
• W3104969749 hasRelatedWork W24586000 @default.
• W3104969749 hasRelatedWork W26965979 @default.

• next