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- W3105073783 endingPage "143" @default.
- W3105073783 startingPage "133" @default.
- W3105073783 abstract "Since the discovery of breast cancer stem cells (CSCs), a significant effort has been made to identify and characterize these cells. It is a generally believe that CSCs play an important role in cancer initiation, therapy resistance, and progression of triple-negative breast cancer (TNBC), an aggressive breast cancer subtype with poor prognosis. Thus, therapies targeting these cells would be a valuable addition to standard treatments that primarily target more differentiated, rapidly dividing TNBC cells. Although several cell surface and intracellular proteins have been described as biomarkers for CSCs, none of these are specific to this population of cells. Recent research is moving toward cellular signaling pathways as targets and biomarkers for CSCs. The WNT pathway, the nuclear factor-kappa B (NF-κB) pathway, and the cholesterol biosynthesis pathway have recently been identified to play a key role in proliferation, survival, and differentiation of CSCs, including those of breast cancer. In this review, we assess recent findings related to these three pathways in breast CSC, with particular focus on TNBC CSCs, and discuss how targeting these pathways, in combination with current standard of care, might prove effective and improve the prognosis of TNBC patients." @default.
- W3105073783 created "2020-11-23" @default.
- W3105073783 creator A5011720560 @default.
- W3105073783 creator A5011755467 @default.
- W3105073783 date "2020-12-08" @default.
- W3105073783 modified "2023-10-17" @default.
- W3105073783 title "Signaling pathways essential for triple-negative breast cancer stem-like cells" @default.
- W3105073783 cites W1518455012 @default.
- W3105073783 cites W1635607892 @default.
- W3105073783 cites W1901059454 @default.
- W3105073783 cites W1972479287 @default.
- W3105073783 cites W1979729004 @default.
- W3105073783 cites W1980281602 @default.
- W3105073783 cites W1983546164 @default.
- W3105073783 cites W1990813262 @default.
- W3105073783 cites W1992595726 @default.
- W3105073783 cites W1993842564 @default.
- W3105073783 cites W1996053472 @default.
- W3105073783 cites W1996420367 @default.
- W3105073783 cites W1997099893 @default.
- W3105073783 cites W2002404925 @default.
- W3105073783 cites W2005895632 @default.
- W3105073783 cites W2006482008 @default.
- W3105073783 cites W2006604617 @default.
- W3105073783 cites W2015171188 @default.
- W3105073783 cites W2020018765 @default.
- W3105073783 cites W2023316892 @default.
- W3105073783 cites W2023427658 @default.
- W3105073783 cites W2024149236 @default.
- W3105073783 cites W2024889549 @default.
- W3105073783 cites W2029938510 @default.
- W3105073783 cites W2032012444 @default.
- W3105073783 cites W2035077913 @default.
- W3105073783 cites W2040430549 @default.
- W3105073783 cites W2043140203 @default.
- W3105073783 cites W2045497655 @default.
- W3105073783 cites W2049920899 @default.
- W3105073783 cites W2065196942 @default.
- W3105073783 cites W2069750786 @default.
- W3105073783 cites W2070212400 @default.
- W3105073783 cites W2070275599 @default.
- W3105073783 cites W2079207159 @default.
- W3105073783 cites W2085134335 @default.
- W3105073783 cites W2086079357 @default.
- W3105073783 cites W2086828029 @default.
- W3105073783 cites W2088094960 @default.
- W3105073783 cites W2089426706 @default.
- W3105073783 cites W2097255042 @default.
- W3105073783 cites W2100545037 @default.
- W3105073783 cites W2101616608 @default.
- W3105073783 cites W2109069210 @default.
- W3105073783 cites W2114505219 @default.
- W3105073783 cites W2118605519 @default.
- W3105073783 cites W2121325716 @default.
- W3105073783 cites W2125519401 @default.
- W3105073783 cites W2126712555 @default.
- W3105073783 cites W2133998111 @default.
- W3105073783 cites W2134539328 @default.
- W3105073783 cites W2135308963 @default.
- W3105073783 cites W2137162822 @default.
- W3105073783 cites W2140987848 @default.
- W3105073783 cites W2141352370 @default.
- W3105073783 cites W2146074268 @default.
- W3105073783 cites W2149542744 @default.
- W3105073783 cites W2150144117 @default.
- W3105073783 cites W2151168046 @default.
- W3105073783 cites W2151408251 @default.
- W3105073783 cites W2153810797 @default.
- W3105073783 cites W2158627893 @default.
- W3105073783 cites W2158742893 @default.
- W3105073783 cites W2159038842 @default.
- W3105073783 cites W2165781463 @default.
- W3105073783 cites W2171811296 @default.
- W3105073783 cites W2260138955 @default.
- W3105073783 cites W2301668203 @default.
- W3105073783 cites W2338118586 @default.
- W3105073783 cites W2515900121 @default.
- W3105073783 cites W2538618317 @default.
- W3105073783 cites W2551025035 @default.
- W3105073783 cites W2551939060 @default.
- W3105073783 cites W2553012279 @default.
- W3105073783 cites W2591330736 @default.
- W3105073783 cites W2593864463 @default.
- W3105073783 cites W2606277010 @default.
- W3105073783 cites W2615693675 @default.
- W3105073783 cites W2624450315 @default.
- W3105073783 cites W2630941289 @default.
- W3105073783 cites W2755285110 @default.
- W3105073783 cites W2758252083 @default.
- W3105073783 cites W2766270233 @default.
- W3105073783 cites W2771110788 @default.
- W3105073783 cites W2783256919 @default.
- W3105073783 cites W2802528458 @default.
- W3105073783 cites W2803503605 @default.
- W3105073783 cites W2804392795 @default.
- W3105073783 cites W2889051661 @default.
- W3105073783 cites W2889646458 @default.
- W3105073783 cites W2896305851 @default.