FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105077348> ?p ?o ?g. }

• W3105077348 endingPage "100917" @default.
• W3105077348 startingPage "100917" @default.
• W3105077348 abstract "We propose an integrated model of aqueous outflow control that employs a pump-conduit system in this article. Our model exploits accepted physiologic regulatory mechanisms such as those of the arterial, venous, and lymphatic systems. Here, we also provide a framework for developing novel diagnostic and therapeutic strategies to improve glaucoma patient care. In the model, the trabecular meshwork distends and recoils in response to continuous physiologic IOP transients like the ocular pulse, blinking, and eye movement. The elasticity of the trabecular meshwork determines cyclic volume changes in Schlemm's canal (SC). Tube-like SC inlet valves provide aqueous entry into the canal, and outlet valve leaflets at collector channels control aqueous exit from SC. Connections between the pressure-sensing trabecular meshwork and the outlet valve leaflets dynamically control flow from SC. Normal function requires regulation of the trabecular meshwork properties that determine distention and recoil. The aqueous pump-conduit provides short-term pressure control by varying stroke volume in response to pressure changes. Modulating TM constituents that regulate stroke volume provides long-term control. The aqueous outflow pump fails in glaucoma due to the loss of trabecular tissue elastance, as well as alterations in ciliary body tension. These processes lead to SC wall apposition and loss of motion. Visible evidence of pump failure includes a lack of pulsatile aqueous discharge into aqueous veins and reduced ability to reflux blood into SC. These alterations in the functional properties are challenging to monitor clinically. Phase-sensitive OCT now permits noninvasive, quantitative measurement of pulse-dependent TM motion in humans. This proposed conceptual model and related techniques offer a novel framework for understanding mechanisms, improving management, and development of therapeutic options for glaucoma." @default.
• W3105077348 created "2020-11-23" @default.
• W3105077348 creator A5008401166 @default.
• W3105077348 creator A5026906414 @default.
• W3105077348 creator A5044338061 @default.
• W3105077348 creator A5050460821 @default.
• W3105077348 creator A5055921342 @default.
• W3105077348 creator A5078179388 @default.
• W3105077348 date "2021-07-01" @default.
• W3105077348 modified "2023-10-05" @default.
• W3105077348 title "Aqueous outflow regulation – 21st century concepts" @default.
• W3105077348 cites W1040119858 @default.
• W3105077348 cites W133149325 @default.
• W3105077348 cites W135515065 @default.
• W3105077348 cites W137263472 @default.
• W3105077348 cites W153578898 @default.
• W3105077348 cites W1541358042 @default.
• W3105077348 cites W1558041297 @default.
• W3105077348 cites W1580774915 @default.
• W3105077348 cites W1585479562 @default.
• W3105077348 cites W1590619267 @default.
• W3105077348 cites W1628148152 @default.
• W3105077348 cites W1828141317 @default.
• W3105077348 cites W1964651297 @default.
• W3105077348 cites W1966197741 @default.
• W3105077348 cites W1968685198 @default.
• W3105077348 cites W1969547738 @default.
• W3105077348 cites W1970239628 @default.
• W3105077348 cites W1971224531 @default.
• W3105077348 cites W1971967234 @default.
• W3105077348 cites W1972145109 @default.
• W3105077348 cites W1973522538 @default.
• W3105077348 cites W1975167183 @default.
• W3105077348 cites W1976010113 @default.
• W3105077348 cites W1979394369 @default.
• W3105077348 cites W1979609698 @default.
• W3105077348 cites W1980735996 @default.
• W3105077348 cites W1982030976 @default.
• W3105077348 cites W1983045804 @default.
• W3105077348 cites W1984699863 @default.
• W3105077348 cites W1985331773 @default.
• W3105077348 cites W1985351346 @default.
• W3105077348 cites W1986248969 @default.
• W3105077348 cites W1986754641 @default.
• W3105077348 cites W1988827464 @default.
• W3105077348 cites W1992270574 @default.
• W3105077348 cites W1992338907 @default.
• W3105077348 cites W1994480994 @default.
• W3105077348 cites W1995875044 @default.
• W3105077348 cites W1997402566 @default.
• W3105077348 cites W1997522513 @default.
• W3105077348 cites W1999055302 @default.
• W3105077348 cites W2000518806 @default.
• W3105077348 cites W2001072222 @default.
• W3105077348 cites W2001668786 @default.
• W3105077348 cites W2004073264 @default.
• W3105077348 cites W2004601667 @default.
• W3105077348 cites W2004925719 @default.
• W3105077348 cites W2005632619 @default.
• W3105077348 cites W2007058770 @default.
• W3105077348 cites W2007180259 @default.
• W3105077348 cites W2008571142 @default.
• W3105077348 cites W2008688504 @default.
• W3105077348 cites W2009072763 @default.
• W3105077348 cites W2011570334 @default.
• W3105077348 cites W2011895392 @default.
• W3105077348 cites W201268120 @default.
• W3105077348 cites W2017851676 @default.
• W3105077348 cites W2018331566 @default.
• W3105077348 cites W2018712443 @default.
• W3105077348 cites W2019184105 @default.
• W3105077348 cites W2023664338 @default.
• W3105077348 cites W2025804886 @default.
• W3105077348 cites W2031508785 @default.
• W3105077348 cites W2034144259 @default.
• W3105077348 cites W2034374996 @default.
• W3105077348 cites W2036145275 @default.
• W3105077348 cites W2038044114 @default.
• W3105077348 cites W2038798818 @default.
• W3105077348 cites W2043882918 @default.
• W3105077348 cites W2046673177 @default.
• W3105077348 cites W2050209293 @default.
• W3105077348 cites W2050455213 @default.
• W3105077348 cites W2051968524 @default.
• W3105077348 cites W2052766715 @default.
• W3105077348 cites W2054111267 @default.
• W3105077348 cites W2054317313 @default.
• W3105077348 cites W2054597520 @default.
• W3105077348 cites W20546881 @default.
• W3105077348 cites W2055701631 @default.
• W3105077348 cites W2055704493 @default.
• W3105077348 cites W205609119 @default.
• W3105077348 cites W2056210683 @default.
• W3105077348 cites W2057846852 @default.
• W3105077348 cites W2059430635 @default.
• W3105077348 cites W2062143592 @default.
• W3105077348 cites W2063645620 @default.
• W3105077348 cites W2066212680 @default.

• next