Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105121826> ?p ?o ?g. }
- W3105121826 abstract "Abstract Bloodfeeding is employed by many parasitic animals and requires specific innovations for efficient feeding. Some of these innovations are molecular features that are related to the inhibition of hemostasis. For example, bloodfeeding insects, bats, and leeches release proteins with anticoagulatory activity through their salivary secretions. The antistasin-like protein family, composed of serine protease inhibitors with one or more antistasin-like domains, is tightly linked to inhibition of hemostasis in leeches. However, this protein family has been recorded also in non-bloodfeeding invertebrates, such as cnidarians, mollusks, polychaetes, and oligochaetes. The present study aims to 1) root the antistasin-like gene tree and delimit the major orthologous groups, 2) identify potential independent origins of salivary proteins secreted by leeches, and 3) identify major changes in domain and/or motif structure within each orthologous group. Five clades containing leech antistasin-like proteins are distinguishable through rigorous phylogenetic analyses based on nine new transcriptomes and a diverse set of comparative data: the trypsin + leukocyte elastase inhibitors clade, the antistasin clade, the therostasin clade, and two additional, unnamed clades. The antistasin-like gene tree supports multiple origins of leech antistasin-like proteins due to the presence of both leech and non-leech sequences in one of the unnamed clades, but a single origin of factor Xa and trypsin + leukocyte elastase inhibitors. This is further supported by three sequence motifs that are exclusive to antistasins, the trypsin + leukocyte elastase inhibitor clade, and the therostasin clade, respectively. We discuss the implications of our findings for the evolution of this diverse family of leech anticoagulants." @default.
- W3105121826 created "2020-11-23" @default.
- W3105121826 creator A5007320531 @default.
- W3105121826 creator A5009736610 @default.
- W3105121826 creator A5065277725 @default.
- W3105121826 creator A5075627115 @default.
- W3105121826 date "2020-11-18" @default.
- W3105121826 modified "2023-09-26" @default.
- W3105121826 title "The Origin and Evolution of Antistasin-like Proteins in Leeches (Hirudinida, Clitellata)" @default.
- W3105121826 cites W1140640105 @default.
- W3105121826 cites W1442469614 @default.
- W3105121826 cites W1508206237 @default.
- W3105121826 cites W1522001606 @default.
- W3105121826 cites W1599049360 @default.
- W3105121826 cites W1601949152 @default.
- W3105121826 cites W1709815505 @default.
- W3105121826 cites W173762069 @default.
- W3105121826 cites W1892723216 @default.
- W3105121826 cites W1964217196 @default.
- W3105121826 cites W1966047761 @default.
- W3105121826 cites W1972370260 @default.
- W3105121826 cites W1972420549 @default.
- W3105121826 cites W1981034625 @default.
- W3105121826 cites W1981357810 @default.
- W3105121826 cites W1988714638 @default.
- W3105121826 cites W1992790401 @default.
- W3105121826 cites W1993837698 @default.
- W3105121826 cites W1996855320 @default.
- W3105121826 cites W1999982795 @default.
- W3105121826 cites W2000202783 @default.
- W3105121826 cites W2004149254 @default.
- W3105121826 cites W2009338423 @default.
- W3105121826 cites W2011342718 @default.
- W3105121826 cites W2011657487 @default.
- W3105121826 cites W2013450677 @default.
- W3105121826 cites W2013973352 @default.
- W3105121826 cites W2014998794 @default.
- W3105121826 cites W2016275544 @default.
- W3105121826 cites W2019174277 @default.
- W3105121826 cites W2023491792 @default.
- W3105121826 cites W2027433216 @default.
- W3105121826 cites W2032374629 @default.
- W3105121826 cites W2040158877 @default.
- W3105121826 cites W2052509494 @default.
- W3105121826 cites W2055885078 @default.
- W3105121826 cites W2060584527 @default.
- W3105121826 cites W2061384405 @default.
- W3105121826 cites W2063899838 @default.
- W3105121826 cites W2065234600 @default.
- W3105121826 cites W2068432930 @default.
- W3105121826 cites W2078288199 @default.
- W3105121826 cites W2080083275 @default.
- W3105121826 cites W2080322206 @default.
- W3105121826 cites W2081797239 @default.
- W3105121826 cites W2083733554 @default.
- W3105121826 cites W2086007570 @default.
- W3105121826 cites W2088315712 @default.
- W3105121826 cites W2090591552 @default.
- W3105121826 cites W2093367595 @default.
- W3105121826 cites W2094201044 @default.
- W3105121826 cites W2094561830 @default.
- W3105121826 cites W2101291993 @default.
- W3105121826 cites W2110509020 @default.
- W3105121826 cites W2111647009 @default.
- W3105121826 cites W2112372263 @default.
- W3105121826 cites W2127648442 @default.
- W3105121826 cites W2131271579 @default.
- W3105121826 cites W2139982696 @default.
- W3105121826 cites W2144363281 @default.
- W3105121826 cites W2152989766 @default.
- W3105121826 cites W2158605937 @default.
- W3105121826 cites W2160378127 @default.
- W3105121826 cites W2161033884 @default.
- W3105121826 cites W2161609934 @default.
- W3105121826 cites W2165801055 @default.
- W3105121826 cites W2167252644 @default.
- W3105121826 cites W2171293116 @default.
- W3105121826 cites W2224056471 @default.
- W3105121826 cites W2254721415 @default.
- W3105121826 cites W2268462766 @default.
- W3105121826 cites W2502516317 @default.
- W3105121826 cites W2520833751 @default.
- W3105121826 cites W2540782276 @default.
- W3105121826 cites W2618907414 @default.
- W3105121826 cites W2793484085 @default.
- W3105121826 cites W2794224486 @default.
- W3105121826 cites W2803329215 @default.
- W3105121826 cites W2808210182 @default.
- W3105121826 cites W2898361348 @default.
- W3105121826 cites W2914936117 @default.
- W3105121826 cites W2941891753 @default.
- W3105121826 cites W2947860983 @default.
- W3105121826 cites W2948976136 @default.
- W3105121826 cites W2967919661 @default.
- W3105121826 cites W2989548456 @default.
- W3105121826 cites W2991106109 @default.
- W3105121826 cites W3036712513 @default.
- W3105121826 cites W3044102506 @default.
- W3105121826 cites W3046876757 @default.
- W3105121826 cites W4297851814 @default.