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- W3105166013 abstract "Abstract Rituximab, a B cell-depleting therapy, is indicated for treating a growing number of autoantibody-mediated autoimmune disorders. However, relapses can occur after treatment and autoantibody-producing B cell subsets may be found during relapses. It is not understood if these autoantibody-producing B cell subsets emerge from the failed depletion of pre-existing B cells or are re-generated de novo . To further define the mechanisms that cause post-rituximab relapse, we studied patients with autoantibody-mediated muscle-specific kinase (MuSK) myasthenia gravis (MG) who relapsed after treatment. We carried out single-cell transcriptional and B cell receptor (BCR) profiling on longitudinal B cell samples. We identified clones present prior to therapy that continued to persist during relapse. Persistent B cell clones included both antibody-secreting cells and memory B cells characterized by gene expression signatures associated with B cell survival. A subset of persistent antibody-secreting cells and memory B cells were specific for the MuSK autoantigen. These results demonstrate that rituximab is not fully effective at eliminating autoantibody-producing B cells and provide a mechanistic understanding of post-rituximab relapse in MuSK MG." @default.
- W3105166013 created "2020-11-23" @default.
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- W3105166013 date "2019-11-14" @default.
- W3105166013 modified "2023-10-13" @default.
- W3105166013 title "Single-cell repertoire tracing identifies rituximab refractory B cells during myasthenia gravis relapses" @default.
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- W3105166013 cites W1964895626 @default.
- W3105166013 cites W1985380203 @default.
- W3105166013 cites W1989059483 @default.
- W3105166013 cites W1993573963 @default.
- W3105166013 cites W1998618256 @default.
- W3105166013 cites W2011557149 @default.
- W3105166013 cites W2021398160 @default.
- W3105166013 cites W2027266940 @default.
- W3105166013 cites W2029525307 @default.
- W3105166013 cites W2041047359 @default.
- W3105166013 cites W2045807214 @default.
- W3105166013 cites W2046712343 @default.
- W3105166013 cites W2051022408 @default.
- W3105166013 cites W2054504604 @default.
- W3105166013 cites W2054663993 @default.
- W3105166013 cites W2063805578 @default.
- W3105166013 cites W2077158310 @default.
- W3105166013 cites W2077570217 @default.
- W3105166013 cites W2082722055 @default.
- W3105166013 cites W2084056567 @default.
- W3105166013 cites W2087404852 @default.
- W3105166013 cites W2089863875 @default.
- W3105166013 cites W2096463706 @default.
- W3105166013 cites W2107024251 @default.
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- W3105166013 cites W2127971170 @default.
- W3105166013 cites W2128336179 @default.
- W3105166013 cites W2131286564 @default.
- W3105166013 cites W2133957385 @default.
- W3105166013 cites W2136590857 @default.
- W3105166013 cites W2141111992 @default.
- W3105166013 cites W2142081242 @default.
- W3105166013 cites W2146392061 @default.
- W3105166013 cites W2148646540 @default.
- W3105166013 cites W2150721047 @default.
- W3105166013 cites W2151558930 @default.
- W3105166013 cites W2162387968 @default.
- W3105166013 cites W2177154523 @default.
- W3105166013 cites W2336228367 @default.
- W3105166013 cites W2343191045 @default.
- W3105166013 cites W2345356016 @default.
- W3105166013 cites W2473078810 @default.
- W3105166013 cites W2555422834 @default.
- W3105166013 cites W2594817103 @default.
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- W3105166013 cites W2745071332 @default.
- W3105166013 cites W2750731598 @default.
- W3105166013 cites W2770797413 @default.
- W3105166013 cites W2794480084 @default.
- W3105166013 cites W2795707233 @default.
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- W3105166013 doi "https://doi.org/10.1101/840389" @default.
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