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• W3105177586 abstract "Abstract Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimer’s disease with Tau oligomers suspected as the most toxic agent. Tau is a client of Hsp90, though it is unclear whether and how the chaperone massages the structure of intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from the very broad conformational ensemble of Tau: Tau in solution is highly dynamic and polymorphic, though ‘paper-clip’-shaped by long-range contacts. Interaction with Hsp90 promotes an open Tau conformation, which we identify as the molecular basis for the formation of small Tau oligomers by exposure of the aggregation-prone repeat domain to other Tau molecules. At the same time, formation of Tau fibrils is inhibited. We therefore provide the nanometer-scale zoom into chaperoning an amyloid client, highlighting formation of oligomers as the consequence of this biologically relevant interaction." @default.
• W3105177586 created "2020-11-23" @default.
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• W3105177586 date "2019-04-19" @default.
• W3105177586 modified "2023-10-16" @default.
• W3105177586 title "The molecular mechanism of Hsp90-induced oligomerization of Tau" @default.
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• W3105177586 doi "https://doi.org/10.1101/614289" @default.
• W3105177586 hasPublicationYear "2019" @default.
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