FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105268545> ?p ?o ?g. }

• W3105268545 endingPage "350" @default.
• W3105268545 startingPage "342" @default.
• W3105268545 abstract "Megakaryocytes (MKs) are platelet progenitor stem cells found in the bone marrow. Platelets obtained from blood draws can be used for therapeutic applications, especially platelet transfusion. The needs for platelet transfusions for clinical situation is increasing, due in part to the growing number of patients undergoing chemotherapy. Platelets obtained from donors, however, have the disadvantages of a limited storage lifespan and the risk of donor-related infection. Extensive effort has therefore been directed at manufacturing platelets ex vivo. Here, we review ex vivo technologies for MK development, focusing on human adipose tissue-derived mesenchymal stem/stromal cell line (ASCL)-based strategies and their potential clinical application. Bone marrow and adipose tissues contain mesenchymal stem/stromal cells that have an ability to differentiate into MKs, which release platelets. Taking advantage of this mechanism, we developed a donor-independent system for manufacturing platelets for clinical application using ASCL established from adipose-derived mesenchymal stem/stromal cells (ASCs). Culture of ASCs with endogenous thrombopoietin and its receptor c-MPL, and endogenous genes such as p45NF-E2 leads to MK differentiation and subsequent platelet production. ASCs compose heterogeneous cells, however, and are not suitable for clinical application. Thus, we established ASCLs, which expand into a more homogeneous population, and fulfill the criteria for mesenchymal stem cells set by the International Society for Cellular Therapy. Using our ASCL culture system with MK lineage induction medium without recombinant thrombopoietin led to peak production of platelets within 12 days, which may be sufficient for clinical application." @default.
• W3105268545 created "2020-11-23" @default.
• W3105268545 creator A5008941892 @default.
• W3105268545 creator A5035039202 @default.
• W3105268545 creator A5074835045 @default.
• W3105268545 date "2021-02-01" @default.
• W3105268545 modified "2023-10-15" @default.
• W3105268545 title "Platelet production using adipose‐derived mesenchymal stem cells: Mechanistic studies and clinical application" @default.
• W3105268545 cites W1570842275 @default.
• W3105268545 cites W1865033903 @default.
• W3105268545 cites W1970018107 @default.
• W3105268545 cites W1976522401 @default.
• W3105268545 cites W1990318696 @default.
• W3105268545 cites W1990630282 @default.
• W3105268545 cites W2000115558 @default.
• W3105268545 cites W2000912956 @default.
• W3105268545 cites W2000927180 @default.
• W3105268545 cites W2005744447 @default.
• W3105268545 cites W2025063645 @default.
• W3105268545 cites W2027405897 @default.
• W3105268545 cites W2027545578 @default.
• W3105268545 cites W2028885274 @default.
• W3105268545 cites W2032794908 @default.
• W3105268545 cites W2038818733 @default.
• W3105268545 cites W2039803934 @default.
• W3105268545 cites W2040625919 @default.
• W3105268545 cites W2041937458 @default.
• W3105268545 cites W2050301732 @default.
• W3105268545 cites W2074435893 @default.
• W3105268545 cites W2075751822 @default.
• W3105268545 cites W2079296889 @default.
• W3105268545 cites W2081185151 @default.
• W3105268545 cites W2083352067 @default.
• W3105268545 cites W2094877790 @default.
• W3105268545 cites W2096151228 @default.
• W3105268545 cites W2099181244 @default.
• W3105268545 cites W2104106417 @default.
• W3105268545 cites W2143531841 @default.
• W3105268545 cites W2144502153 @default.
• W3105268545 cites W2159714953 @default.
• W3105268545 cites W2161676260 @default.
• W3105268545 cites W2295486245 @default.
• W3105268545 cites W2314393727 @default.
• W3105268545 cites W2318106569 @default.
• W3105268545 cites W2329076138 @default.
• W3105268545 cites W2403229308 @default.
• W3105268545 cites W2460479900 @default.
• W3105268545 cites W2617354959 @default.
• W3105268545 cites W2734168001 @default.
• W3105268545 cites W2748810909 @default.
• W3105268545 cites W2883086294 @default.
• W3105268545 cites W2885873098 @default.
• W3105268545 cites W2903522501 @default.
• W3105268545 cites W2972562768 @default.
• W3105268545 cites W3001665949 @default.
• W3105268545 cites W3016104298 @default.
• W3105268545 cites W3087385265 @default.
• W3105268545 cites W3105268545 @default.
• W3105268545 cites W4211141663 @default.
• W3105268545 cites W4229977181 @default.
• W3105268545 cites W4256036783 @default.
• W3105268545 cites W95207813 @default.
• W3105268545 doi "https://doi.org/10.1111/jth.15181" @default.
• W3105268545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7898515" @default.
• W3105268545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33217130" @default.
• W3105268545 hasPublicationYear "2021" @default.
• W3105268545 type Work @default.
• W3105268545 sameAs 3105268545 @default.
• W3105268545 citedByCount "10" @default.
• W3105268545 countsByYear W31052685452021 @default.
• W3105268545 countsByYear W31052685452022 @default.
• W3105268545 countsByYear W31052685452023 @default.
• W3105268545 crossrefType "journal-article" @default.
• W3105268545 hasAuthorship W3105268545A5008941892 @default.
• W3105268545 hasAuthorship W3105268545A5035039202 @default.
• W3105268545 hasAuthorship W3105268545A5074835045 @default.
• W3105268545 hasBestOaLocation W31052685451 @default.
• W3105268545 hasConcept C109159458 @default.
• W3105268545 hasConcept C123012128 @default.
• W3105268545 hasConcept C126322002 @default.
• W3105268545 hasConcept C143441281 @default.
• W3105268545 hasConcept C150903083 @default.
• W3105268545 hasConcept C16930146 @default.
• W3105268545 hasConcept C171089720 @default.
• W3105268545 hasConcept C198826908 @default.
• W3105268545 hasConcept C201750760 @default.
• W3105268545 hasConcept C202751555 @default.
• W3105268545 hasConcept C203014093 @default.
• W3105268545 hasConcept C207001950 @default.
• W3105268545 hasConcept C20875687 @default.
• W3105268545 hasConcept C26291073 @default.
• W3105268545 hasConcept C2776689292 @default.
• W3105268545 hasConcept C2777863708 @default.
• W3105268545 hasConcept C2780007613 @default.
• W3105268545 hasConcept C28328180 @default.
• W3105268545 hasConcept C502942594 @default.
• W3105268545 hasConcept C55493867 @default.
• W3105268545 hasConcept C71924100 @default.

• next