FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105272009> ?p ?o ?g. }

• W3105272009 endingPage "153412" @default.
• W3105272009 startingPage "153412" @default.
• W3105272009 abstract "Abstract Background Naringenin is naturally isolated from citrus fruits possessing many pharmacological activities. However, little is known about the effect of naringenin on nonalcoholic steatohepatitis (NASH) in the model of metabolic syndrome. Purpose The present study is aimed to investigate the effect of naringenin on NASH in 12-mo-old male ApoE−/− mice and its possible underlying mechanism. Methods In vivo, 12-mo-old male ApoE−/− mice were administrated with naringenin by intragastric gavage for 12 weeks. At the end of experiment, the blood samples and liver tissues were collected. Metabolic parameters in serum, levels of triglyceride, cholesterol and hydroxyproline, activities of antioxidant enzymes, and content of inflammatory cytokines (TNF-α and IL-6) in liver were examined by corresponding assay kits. Pathological changes in liver were observed by hematoxylin-eosin, oil red O, masson's trichrome, picro-sirius red and senescence β-galactosidase staining. Dihydroethidium was used for detection of reactive oxygen species (ROS). In vitro, AML-12 cells were treated with oleic acid in the presence or absence of naringenin for 24 h. Transfection of SIRT1 siRNA was also conducted in vitro. Lipid accumulation, cellular ROS generation, malondialdehyde content, antioxidant enzyme activities and secretion levels of TNF-α and IL-6 were examined. Both in vivo and in vitro, gene expressions were detected by real-time PCR or western blot. Results Naringenin administration improved metabolic parameters, suppressed hepatic steatosis, regulated expression of genes involved in lipid metabolism (FASN, SCD1, PPARα and CPT1α), reduced hepatic fibrosis and cell senescence, inhibited hepatic inflammation as evidenced by the decreased macrophage recruitment and content of TNF-α and IL-6, and reduced hepatic oxidative stress by suppressing ROS generation and normalizing activities of antioxidant enzymes. Notably, naringenin administration increased hepatic SIRT1 protein expression and activity along with the increased deacetylation of liver kinase B1 (LKB1), PGC1α and NF-κB. In vitro study, the benefits of naringenin on lipid accumulation, oxidative stress and inflammation were diminished by SIRT1 siRNA transfection. Conclusions These results indicate that naringenin administration may be a potential curative therapy for NASH treatment and the activation of hepatic SIRT1-mediated signaling cascades is involved in its beneficial effects." @default.
• W3105272009 created "2020-11-23" @default.
• W3105272009 creator A5006579294 @default.
• W3105272009 creator A5007429039 @default.
• W3105272009 creator A5010492272 @default.
• W3105272009 creator A5039625704 @default.
• W3105272009 date "2021-01-01" @default.
• W3105272009 modified "2023-10-05" @default.
• W3105272009 title "Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe−/−mice: role of SIRT1" @default.
• W3105272009 cites W169610125 @default.
• W3105272009 cites W1914169609 @default.
• W3105272009 cites W1969502688 @default.
• W3105272009 cites W1978302160 @default.
• W3105272009 cites W1980683111 @default.
• W3105272009 cites W2005103041 @default.
• W3105272009 cites W2035252462 @default.
• W3105272009 cites W2082669413 @default.
• W3105272009 cites W2088381487 @default.
• W3105272009 cites W2119441268 @default.
• W3105272009 cites W2298308787 @default.
• W3105272009 cites W2722130257 @default.
• W3105272009 cites W2730267177 @default.
• W3105272009 cites W2734724639 @default.
• W3105272009 cites W2741636306 @default.
• W3105272009 cites W2761832333 @default.
• W3105272009 cites W2770129291 @default.
• W3105272009 cites W2772932593 @default.
• W3105272009 cites W2800261814 @default.
• W3105272009 cites W2891254367 @default.
• W3105272009 cites W2899389750 @default.
• W3105272009 cites W2931860045 @default.
• W3105272009 cites W2950304894 @default.
• W3105272009 cites W2988316951 @default.
• W3105272009 cites W2990473002 @default.
• W3105272009 cites W3002184305 @default.
• W3105272009 cites W3006891752 @default.
• W3105272009 cites W3012534369 @default.
• W3105272009 cites W3012993275 @default.
• W3105272009 cites W3016640598 @default.
• W3105272009 cites W3043487771 @default.
• W3105272009 cites W3084086545 @default.
• W3105272009 doi "https://doi.org/10.1016/j.phymed.2020.153412" @default.
• W3105272009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33234364" @default.
• W3105272009 hasPublicationYear "2021" @default.
• W3105272009 type Work @default.
• W3105272009 sameAs 3105272009 @default.
• W3105272009 citedByCount "36" @default.
• W3105272009 countsByYear W31052720092021 @default.
• W3105272009 countsByYear W31052720092022 @default.
• W3105272009 countsByYear W31052720092023 @default.
• W3105272009 crossrefType "journal-article" @default.
• W3105272009 hasAuthorship W3105272009A5006579294 @default.
• W3105272009 hasAuthorship W3105272009A5007429039 @default.
• W3105272009 hasAuthorship W3105272009A5010492272 @default.
• W3105272009 hasAuthorship W3105272009A5039625704 @default.
• W3105272009 hasConcept C126322002 @default.
• W3105272009 hasConcept C134018914 @default.
• W3105272009 hasConcept C185592680 @default.
• W3105272009 hasConcept C2776175330 @default.
• W3105272009 hasConcept C2776848411 @default.
• W3105272009 hasConcept C2776954865 @default.
• W3105272009 hasConcept C2778004101 @default.
• W3105272009 hasConcept C2778772119 @default.
• W3105272009 hasConcept C2779054382 @default.
• W3105272009 hasConcept C2779134260 @default.
• W3105272009 hasConcept C3018708256 @default.
• W3105272009 hasConcept C55493867 @default.
• W3105272009 hasConcept C71924100 @default.
• W3105272009 hasConcept C90924648 @default.
• W3105272009 hasConceptScore W3105272009C126322002 @default.
• W3105272009 hasConceptScore W3105272009C134018914 @default.
• W3105272009 hasConceptScore W3105272009C185592680 @default.
• W3105272009 hasConceptScore W3105272009C2776175330 @default.
• W3105272009 hasConceptScore W3105272009C2776848411 @default.
• W3105272009 hasConceptScore W3105272009C2776954865 @default.
• W3105272009 hasConceptScore W3105272009C2778004101 @default.
• W3105272009 hasConceptScore W3105272009C2778772119 @default.
• W3105272009 hasConceptScore W3105272009C2779054382 @default.
• W3105272009 hasConceptScore W3105272009C2779134260 @default.
• W3105272009 hasConceptScore W3105272009C3018708256 @default.
• W3105272009 hasConceptScore W3105272009C55493867 @default.
• W3105272009 hasConceptScore W3105272009C71924100 @default.
• W3105272009 hasConceptScore W3105272009C90924648 @default.
• W3105272009 hasFunder F4320321001 @default.
• W3105272009 hasLocation W31052720091 @default.
• W3105272009 hasOpenAccess W3105272009 @default.
• W3105272009 hasPrimaryLocation W31052720091 @default.
• W3105272009 hasRelatedWork W1695174616 @default.
• W3105272009 hasRelatedWork W1973843004 @default.
• W3105272009 hasRelatedWork W2026143540 @default.
• W3105272009 hasRelatedWork W2032775519 @default.
• W3105272009 hasRelatedWork W2050769318 @default.
• W3105272009 hasRelatedWork W2083652468 @default.
• W3105272009 hasRelatedWork W2135369758 @default.
• W3105272009 hasRelatedWork W2748952813 @default.
• W3105272009 hasRelatedWork W2797640654 @default.
• W3105272009 hasRelatedWork W3157082172 @default.
• W3105272009 hasVolume "81" @default.

• next