FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105287773> ?p ?o ?g. }

• W3105287773 abstract "Abstract During chronic infections and in microbiota, bacteria predominantly colonize their hosts as multicellular structures called biofilms. Despite their ubiquity in vivo , we still lack a basic understanding of how they interact with biological tissues, and ultimately how they influence host physiology. A common assumption is that biofilms interact with their hosts biochemically. However, the contributions of mechanics, while being central to the process of biofilm formation, have been vastly overlooked as a factor influencing host physiology. Specifically, how biofilms form on soft, tissue-like materials remains unknown. Here we show that biofilms can deform soft substrates by transmission of internally-generated mechanical stresses. We found that biofilms from both Vibrio cholerae and Pseudomonas aeruginosa can induce large deformations of soft synthetic hydrogels. Using a combination of mechanical measurements and mutants in matrix components, we found that biofilms deform their substrates by simultaneous buckling and adhesion. Specifically, mechanical constraints opposing growth causes biofilm buckling, while matrix components maintaining surface adhesion transmit buckling forces to the substrate. Finally, we demonstrate that biofilms can generate sufficient mechanical stress to deform and disrupt soft epithelial cell monolayers, suggesting that these forces can damage a host independently of typical virulence factors. Altogether, our results illustrate that forces generated by bacterial communities play an important role not only in biofilm morphogenesis but also in host physiology, suggesting a mechanical mode of infection." @default.
• W3105287773 created "2020-11-23" @default.
• W3105287773 creator A5003226816 @default.
• W3105287773 creator A5024025171 @default.
• W3105287773 creator A5039005479 @default.
• W3105287773 creator A5077587137 @default.
• W3105287773 date "2020-01-30" @default.
• W3105287773 modified "2023-10-18" @default.
• W3105287773 title "Biofilms deform soft surfaces and disrupt epithelia" @default.
• W3105287773 cites W1557428043 @default.
• W3105287773 cites W1935506419 @default.
• W3105287773 cites W1966431070 @default.
• W3105287773 cites W1966729619 @default.
• W3105287773 cites W1994507658 @default.
• W3105287773 cites W1998656362 @default.
• W3105287773 cites W1999657569 @default.
• W3105287773 cites W2003346916 @default.
• W3105287773 cites W2007716298 @default.
• W3105287773 cites W2033701627 @default.
• W3105287773 cites W2043015302 @default.
• W3105287773 cites W2045429993 @default.
• W3105287773 cites W2050575057 @default.
• W3105287773 cites W2054635074 @default.
• W3105287773 cites W2055073693 @default.
• W3105287773 cites W2061670564 @default.
• W3105287773 cites W2070300719 @default.
• W3105287773 cites W2096163314 @default.
• W3105287773 cites W2102072203 @default.
• W3105287773 cites W2106503480 @default.
• W3105287773 cites W2115933619 @default.
• W3105287773 cites W2117589927 @default.
• W3105287773 cites W2119610782 @default.
• W3105287773 cites W2124439712 @default.
• W3105287773 cites W2128879347 @default.
• W3105287773 cites W2131727615 @default.
• W3105287773 cites W2138134673 @default.
• W3105287773 cites W2147185759 @default.
• W3105287773 cites W2163949809 @default.
• W3105287773 cites W2178278536 @default.
• W3105287773 cites W2294864444 @default.
• W3105287773 cites W2310269848 @default.
• W3105287773 cites W2417458553 @default.
• W3105287773 cites W2480010979 @default.
• W3105287773 cites W2507231691 @default.
• W3105287773 cites W2582215292 @default.
• W3105287773 cites W2767772078 @default.
• W3105287773 cites W2780179719 @default.
• W3105287773 cites W2782738274 @default.
• W3105287773 cites W2786123473 @default.
• W3105287773 cites W2795091386 @default.
• W3105287773 cites W2800679771 @default.
• W3105287773 cites W2805325890 @default.
• W3105287773 cites W2898236010 @default.
• W3105287773 cites W2900643491 @default.
• W3105287773 cites W2922282781 @default.
• W3105287773 cites W2998839559 @default.
• W3105287773 cites W4237522464 @default.
• W3105287773 cites W4378346956 @default.
• W3105287773 doi "https://doi.org/10.1101/2020.01.29.923060" @default.
• W3105287773 hasPublicationYear "2020" @default.
• W3105287773 type Work @default.
• W3105287773 sameAs 3105287773 @default.
• W3105287773 citedByCount "4" @default.
• W3105287773 countsByYear W31052877732020 @default.
• W3105287773 countsByYear W31052877732021 @default.
• W3105287773 countsByYear W31052877732023 @default.
• W3105287773 crossrefType "posted-content" @default.
• W3105287773 hasAuthorship W3105287773A5003226816 @default.
• W3105287773 hasAuthorship W3105287773A5024025171 @default.
• W3105287773 hasAuthorship W3105287773A5039005479 @default.
• W3105287773 hasAuthorship W3105287773A5077587137 @default.
• W3105287773 hasBestOaLocation W31052877731 @default.
• W3105287773 hasConcept C104317684 @default.
• W3105287773 hasConcept C12554922 @default.
• W3105287773 hasConcept C126831891 @default.
• W3105287773 hasConcept C1491633281 @default.
• W3105287773 hasConcept C171250308 @default.
• W3105287773 hasConcept C178790620 @default.
• W3105287773 hasConcept C185592680 @default.
• W3105287773 hasConcept C18903297 @default.
• W3105287773 hasConcept C189165786 @default.
• W3105287773 hasConcept C192562407 @default.
• W3105287773 hasConcept C40692019 @default.
• W3105287773 hasConcept C523546767 @default.
• W3105287773 hasConcept C54355233 @default.
• W3105287773 hasConcept C55493867 @default.
• W3105287773 hasConcept C58123911 @default.
• W3105287773 hasConcept C60987743 @default.
• W3105287773 hasConcept C74318829 @default.
• W3105287773 hasConcept C84416704 @default.
• W3105287773 hasConcept C86803240 @default.
• W3105287773 hasConcept C89423630 @default.
• W3105287773 hasConcept C95444343 @default.
• W3105287773 hasConceptScore W3105287773C104317684 @default.
• W3105287773 hasConceptScore W3105287773C12554922 @default.
• W3105287773 hasConceptScore W3105287773C126831891 @default.
• W3105287773 hasConceptScore W3105287773C1491633281 @default.
• W3105287773 hasConceptScore W3105287773C171250308 @default.
• W3105287773 hasConceptScore W3105287773C178790620 @default.
• W3105287773 hasConceptScore W3105287773C185592680 @default.

• next