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- W3105392993 abstract "Indazoles represent a privileged motif in drug discovery. However, the formation of highly substituted indazoles can require the execution of lengthy synthetic routes with minimal opportunities to introduce diversity. In this report, we disclose the development of a late-stage diversification strategy for the 4- and 5-positions of 4,5,6-trisubstituted indazoles. A regioselective C–H functionalization and subsequent nucleophilic aromatic substitution provide two sequential points of diversification. The synthetic sequence delivers rapid access to an array of 4,5,6-trisubstituted indazoles in only four steps from readily available starting materials." @default.
- W3105392993 created "2020-11-23" @default.
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- W3105392993 date "2020-11-09" @default.
- W3105392993 modified "2023-10-16" @default.
- W3105392993 title "Development of a Late-Stage Diversification Strategy for the 4- and 5-Positions of 4,5,6-Trisubstituted Indazoles" @default.
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- W3105392993 doi "https://doi.org/10.1021/acs.orglett.0c03440" @default.
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