FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105397584> ?p ?o ?g. }

• W3105397584 endingPage "795" @default.
• W3105397584 startingPage "795" @default.
• W3105397584 abstract "Bacterial resistance to antibiotics has catalysed interest in alternative antimicrobial strategies. Bacteriophages (phages) are viruses of bacteria with a long history of successful therapeutic use. Phage therapy is a promising antibacterial strategy for infections with a biofilm component, including recalcitrant bone and joint infections, which have significant social, financial and human impacts. Here, we report a systematic review of the safety and efficacy of phage therapy for the treatment of bone and joint infections. Three electronic databases were systematically searched for articles that reported primary data about human phage therapy for bone and joint infections. Two authors independently assessed study eligibility and performed data extraction. Seventeen reports were eligible for inclusion in this review, representing the treatment of 277 patients. A cautionary, crude, efficacy estimate revealed that 93.1% (n = 258/277) achieved clinical resolution, 3.3% (n = 9/277) had improvement and 3.6% (n = 10/277) showed no improvement. Seven of the nine reports that directly commented on the safety of phage therapy did not express safety concerns. The adverse effects reported in the remaining two were not severe and were linked to the presence of contaminating endotoxins and pre-existing liver pathology in a patient treated with high-titre intravenous phage therapy. Three other reports, from 1940-1987, offered general comments on the safety of phage therapy and documented adverse effects consistent with endotoxin co-administration concomitant with the use of raw phage lysates. Together, the reports identified by this review suggest that appropriately purified phages represent a safe and highly efficacious treatment option for complex and intractable bone and joint infections." @default.
• W3105397584 created "2020-11-23" @default.
• W3105397584 creator A5006757242 @default.
• W3105397584 creator A5010916796 @default.
• W3105397584 creator A5090221525 @default.
• W3105397584 date "2020-11-10" @default.
• W3105397584 modified "2023-10-16" @default.
• W3105397584 title "The Safety and Efficacy of Phage Therapy for Bone and Joint Infections: A Systematic Review" @default.
• W3105397584 cites W124278798 @default.
• W3105397584 cites W1974394752 @default.
• W3105397584 cites W1974881706 @default.
• W3105397584 cites W1979423827 @default.
• W3105397584 cites W1983255179 @default.
• W3105397584 cites W1989131500 @default.
• W3105397584 cites W2027117705 @default.
• W3105397584 cites W2045119482 @default.
• W3105397584 cites W2048361405 @default.
• W3105397584 cites W2065419878 @default.
• W3105397584 cites W2080936059 @default.
• W3105397584 cites W2084455538 @default.
• W3105397584 cites W2123978130 @default.
• W3105397584 cites W2132383729 @default.
• W3105397584 cites W2156339330 @default.
• W3105397584 cites W2260055920 @default.
• W3105397584 cites W2410768742 @default.
• W3105397584 cites W2418891214 @default.
• W3105397584 cites W2468433674 @default.
• W3105397584 cites W2588681363 @default.
• W3105397584 cites W2603755876 @default.
• W3105397584 cites W2606104114 @default.
• W3105397584 cites W2606636476 @default.
• W3105397584 cites W2607423292 @default.
• W3105397584 cites W2746052463 @default.
• W3105397584 cites W2747615902 @default.
• W3105397584 cites W2758498307 @default.
• W3105397584 cites W2767885898 @default.
• W3105397584 cites W2774393973 @default.
• W3105397584 cites W2798058122 @default.
• W3105397584 cites W2801117539 @default.
• W3105397584 cites W2883285900 @default.
• W3105397584 cites W2889689336 @default.
• W3105397584 cites W2890733318 @default.
• W3105397584 cites W2890997328 @default.
• W3105397584 cites W2895188866 @default.
• W3105397584 cites W2898384637 @default.
• W3105397584 cites W2915167646 @default.
• W3105397584 cites W2922139929 @default.
• W3105397584 cites W2953305767 @default.
• W3105397584 cites W2963246688 @default.
• W3105397584 cites W2974451646 @default.
• W3105397584 cites W2974467838 @default.
• W3105397584 cites W2981490961 @default.
• W3105397584 cites W3007565704 @default.
• W3105397584 cites W3012760780 @default.
• W3105397584 cites W3021855683 @default.
• W3105397584 cites W3026088979 @default.
• W3105397584 cites W3033222646 @default.
• W3105397584 cites W3045118558 @default.
• W3105397584 cites W3046551743 @default.
• W3105397584 cites W4255277154 @default.
• W3105397584 cites W81557861 @default.
• W3105397584 doi "https://doi.org/10.3390/antibiotics9110795" @default.
• W3105397584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7697170" @default.
• W3105397584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33182795" @default.
• W3105397584 hasPublicationYear "2020" @default.
• W3105397584 type Work @default.
• W3105397584 sameAs 3105397584 @default.
• W3105397584 citedByCount "23" @default.
• W3105397584 countsByYear W31053975842021 @default.
• W3105397584 countsByYear W31053975842022 @default.
• W3105397584 countsByYear W31053975842023 @default.
• W3105397584 crossrefType "journal-article" @default.
• W3105397584 hasAuthorship W3105397584A5006757242 @default.
• W3105397584 hasAuthorship W3105397584A5010916796 @default.
• W3105397584 hasAuthorship W3105397584A5090221525 @default.
• W3105397584 hasBestOaLocation W31053975841 @default.
• W3105397584 hasConcept C104317684 @default.
• W3105397584 hasConcept C126322002 @default.
• W3105397584 hasConcept C177713679 @default.
• W3105397584 hasConcept C197934379 @default.
• W3105397584 hasConcept C2776441376 @default.
• W3105397584 hasConcept C2779256223 @default.
• W3105397584 hasConcept C4937899 @default.
• W3105397584 hasConcept C501593827 @default.
• W3105397584 hasConcept C535046627 @default.
• W3105397584 hasConcept C547475151 @default.
• W3105397584 hasConcept C55493867 @default.
• W3105397584 hasConcept C71924100 @default.
• W3105397584 hasConcept C86803240 @default.
• W3105397584 hasConcept C89423630 @default.
• W3105397584 hasConceptScore W3105397584C104317684 @default.
• W3105397584 hasConceptScore W3105397584C126322002 @default.
• W3105397584 hasConceptScore W3105397584C177713679 @default.
• W3105397584 hasConceptScore W3105397584C197934379 @default.
• W3105397584 hasConceptScore W3105397584C2776441376 @default.
• W3105397584 hasConceptScore W3105397584C2779256223 @default.
• W3105397584 hasConceptScore W3105397584C4937899 @default.
• W3105397584 hasConceptScore W3105397584C501593827 @default.

• next