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• W3105474311 abstract "There is increasing evidence demonstrating that adult neural stem cells (NSCs) are a cell of origin of glioblastoma. Here we analyzed the interaction between transformed and wild-type NSCs isolated from the adult mouse subventricular zone niche. We found that transformed NSCs are refractory to quiescence-inducing signals. Unexpectedly, we also demonstrated that these cells induce quiescence in surrounding wild-type NSCs in a cell–cell contact and Notch signaling-dependent manner. Our findings therefore suggest that oncogenic mutations are propagated in the stem cell niche not just through cell-intrinsic advantages, but also by outcompeting neighboring stem cells through repression of their proliferation." @default.
• W3105474311 created "2020-11-23" @default.
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• W3105474311 date "2020-11-12" @default.
• W3105474311 modified "2023-10-02" @default.
• W3105474311 title "Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signaling" @default.
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• W3105474311 doi "https://doi.org/10.1101/gad.336917.120" @default.
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