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- W3105488605 abstract "Hematopoietic stem/progenitor cells (HSPCs) are self-renewing, multipotent progenitors that sustain hematopoiesis and occupy the bone marrow. The increasing incidence of obesity has led to an expanding body of literature examining the effects of high fat diet-induced obesity on HSPCs. These studies indicate that diet-induced obesity results in HSPC depletion and overproduction of myeloid cells during stress and steady state hematopoiesis. These effects are mediated by cell autonomous mechanisms and alterations in the HSPC niche. Emerging work is revealing that dietary components in high fat diets or altered by obesity, such as, saturated fatty acids, cholesterol, and vitamin D, have effects on HSPC function that are distinct from obesity." @default.
- W3105488605 created "2020-11-23" @default.
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- W3105488605 date "2020-08-01" @default.
- W3105488605 modified "2023-10-14" @default.
- W3105488605 title "Recent advances in understanding the role of high fat diets and their components on hematopoiesis and the hematopoietic stem cell niche" @default.
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- W3105488605 doi "https://doi.org/10.1016/j.cofs.2020.11.004" @default.
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