Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105502005> ?p ?o ?g. }
- W3105502005 abstract "Abstract Translatome reprogramming is a primary determinant of protein levels during stimuli adaptation. This raises the question: what are the translatome remodelers that reprogram protein output to activate biochemical adaptations. Here, we identify a translational pathway that represses metabolism to safeguard genome integrity. A system-wide MATRIX survey identified the ancient eIF5A as a pH-regulated translation factor that responds to fermentation-induced acidosis. TMT-pulse-SILAC analysis identified several pH-dependent proteins, including the mTORC1 suppressor Tsc2 and the longevity regulator Sirt1. Sirt1 operates as a pH-sensor that deacetylates nuclear eIF5A during anaerobiosis, enabling the cytoplasmic export of eIF5A/Tsc2 mRNA complexes for translational engagement. Tsc2 induction inhibits mTORC1 to suppress cellular metabolism and prevent acidosis-induced DNA damage. Depletion of eIF5A or Tsc2 leads to metabolic re-initiation and proliferation, but at the expense of incurring substantial DNA damage. We suggest that eIF5A operates as a translatome remodeler that suppresses metabolism to shield the genome." @default.
- W3105502005 created "2020-11-23" @default.
- W3105502005 creator A5007004043 @default.
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- W3105502005 creator A5086176677 @default.
- W3105502005 creator A5090982894 @default.
- W3105502005 date "2020-11-13" @default.
- W3105502005 modified "2023-10-15" @default.
- W3105502005 title "A translational program that suppresses metabolism to shield the genome" @default.
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