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• W3105578347 endingPage "140024" @default.
• W3105578347 startingPage "140024" @default.
• W3105578347 abstract "Most animals have separate sexes. The differential expression of gene products, in particular that of gene regulators, is underlying sexual dimorphism. Analyses of sex-biased expression have focused mostly on protein-coding genes. Several lines of evidence indicate that microRNAs, a class of major gene regulators, are likely to have a significant role in sexual dimorphism. This role has not been systematically explored so far. Here, I study the sex-biased expression pattern of microRNAs in the model species Drosophila melanogaster . As with protein-coding genes, sex-biased microRNAs are associated with the reproductive function. Strikingly, contrary to protein-coding genes, male-biased microRNAs are enriched in the X chromosome, whereas female microRNAs are mostly autosomal. I propose that the chromosomal distribution is a consequence of high rates of de novo emergence, and a preference for new microRNAs to be expressed in the testis. I also suggest that demasculinization of the X chromosome may not affect microRNAs. Interestingly, female-biased microRNAs are often encoded within protein-coding genes that are also expressed in females. MicroRNAs with sex-biased expression do not preferentially target sex-biased gene transcripts. These results strongly suggest that the sex-biased expression of microRNAs is mainly a consequence of high rates of microRNA emergence in the X chromosome (male bias) or hitchhiked expression by host genes (female bias)." @default.
• W3105578347 created "2020-11-23" @default.
• W3105578347 creator A5012557025 @default.
• W3105578347 date "2014-04-01" @default.
• W3105578347 modified "2023-10-06" @default.
• W3105578347 title "Sex-biased expression of microRNAs in<i>Drosophila melanogaster</i>" @default.
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• W3105578347 doi "https://doi.org/10.1098/rsob.140024" @default.
• W3105578347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24694940" @default.
• W3105578347 hasPublicationYear "2014" @default.
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