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• W3105617488 abstract "A bstract Understanding temporal regulation of development remains an important challenge. Whereas average, species-typical timing of many developmental processes has been established, less is known about inter-individual variability and correlations in timing of specific events. We addressed these questions in the context of postembryonic development in Caenorhabditis elegans . Based on patterns of locomotor activity of freely moving animals, we inferred durations of four larval stages (L1-L4) in over 100 individuals. Analysis of these data supports several notable conclusions. Individuals have consistently faster or slower rates of development because durations of L1 through L3 stages are positively correlated. The last larval stage, the L4, is less variable than earlier stages and its duration is largely independent of the rate of early larval development, implying existence of two distinct larval epochs. We argue that characteristic patterns of variation and correlation arise because duration of each stage tends to scale relative to total developmental time. This scaling relationship suggests that each larval stage is not limited by an absolute duration, but is instead terminated when a subset of events that must occur prior to adulthood have been completed. The approach described here offers a scalable platform that will facilitate the study of temporal regulation of postembryonic development." @default.
• W3105617488 created "2020-11-23" @default.
• W3105617488 creator A5054228862 @default.
• W3105617488 creator A5071504969 @default.
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• W3105617488 date "2020-11-12" @default.
• W3105617488 modified "2023-10-18" @default.
• W3105617488 title "Inferring temporal organization of postembryonic development from high-content behavioral tracking" @default.
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• W3105617488 doi "https://doi.org/10.1101/2020.11.11.378166" @default.
• W3105617488 hasPublicationYear "2020" @default.
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