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- W3105635996 abstract "This article describes findings derived from electrical stimulation of the brain (ESB), including both experimental studies using animal models, and also clinical studies, in which human patients received ESB to observe therapeutic effects. Early research in the nineteenth century used ESB that elicited discrete motor responses to map motor functions of mammalian cerebral cortex. Subsequent work in the 1930s provided preliminary demonstrations of behavioral plasticity consequent upon such stimulation. In the past 20 years a major cerebellar neuronal network has been delineated that underlies the observed plasticity and is evidently responsible for much of what memory theorists call ‘procedural learning.’ Another principal theme has concerned the reinforcement of motor responses. ESB in specific subcortical regions exerts powerful reinforcing effects that far outweigh those of conventional reinforcers. There exists also a substantial literature on the effects of ESB in humans. Pioneering work in the 1950s and 1960s established the therapeutic effects of ESB in certain subpopulations of patients with severe affective disorders; recent work in the 1990s has extended the beneficial clinical effects of ESB to other conditions including Parkinson's disease and chronic pain." @default.
- W3105635996 created "2020-11-23" @default.
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- W3105635996 date "2001-01-01" @default.
- W3105635996 modified "2023-09-27" @default.
- W3105635996 title "Electrical Stimulation of the Brain" @default.
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- W3105635996 doi "https://doi.org/10.1016/b0-08-043076-7/03418-5" @default.
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