FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105656181> ?p ?o ?g. }

• W3105656181 startingPage "538504" @default.
• W3105656181 abstract "Abstract Transcription factors (TFs) enact precise regulation of gene expression through site-specific, genome-wide binding. Common methods for TF occupancy profiling, such as chromatin immunoprecipitation, are limited by requirement of TF-specific antibodies and provide only endpoint snapshots of TF binding. Alternatively, TF-tagging techniques, in which a TF is fused to a DNA-modifying enzyme that marks TF binding events across the genome as they occur, do not require TF-specific antibodies and offer the potential for unique applications, such as recording of TF occupancy over time and cell type-specificity through conditional expression of the TF-enzyme fusion. Here we create a viral toolkit for one such method, calling cards, and demonstrate that these reagents can be delivered to the live mouse brain and used to report TF occupancy. Further, we establish a Cre-dependent calling cards system, termed Flip-Excision (FLEX) calling cards and, in proof-of-principle experiments, show utility in defining cell type-specific TF profiles and recording and integrating TF binding events across time. This versatile approach will enable unique studies of TF-mediated gene regulation in live animal models." @default.
• W3105656181 created "2020-11-23" @default.
• W3105656181 creator A5007489515 @default.
• W3105656181 creator A5019584451 @default.
• W3105656181 creator A5022326820 @default.
• W3105656181 creator A5036601296 @default.
• W3105656181 creator A5041943054 @default.
• W3105656181 creator A5050964355 @default.
• W3105656181 creator A5051892257 @default.
• W3105656181 creator A5053397369 @default.
• W3105656181 creator A5060720882 @default.
• W3105656181 creator A5063040246 @default.
• W3105656181 creator A5066263942 @default.
• W3105656181 creator A5070141978 @default.
• W3105656181 creator A5084612869 @default.
• W3105656181 creator A5090246550 @default.
• W3105656181 date "2019-10-17" @default.
• W3105656181 modified "2023-09-29" @default.
• W3105656181 title "A viral toolkit for recording transcription factor-DNA interactions in live mouse tissues" @default.
• W3105656181 cites W1573323739 @default.
• W3105656181 cites W1835845730 @default.
• W3105656181 cites W1971578941 @default.
• W3105656181 cites W1972950405 @default.
• W3105656181 cites W1981030303 @default.
• W3105656181 cites W2000742564 @default.
• W3105656181 cites W2006794246 @default.
• W3105656181 cites W2009869892 @default.
• W3105656181 cites W2014677321 @default.
• W3105656181 cites W2024960915 @default.
• W3105656181 cites W2025260963 @default.
• W3105656181 cites W2027917639 @default.
• W3105656181 cites W2033286875 @default.
• W3105656181 cites W2033800157 @default.
• W3105656181 cites W2040321376 @default.
• W3105656181 cites W2045362835 @default.
• W3105656181 cites W2047749014 @default.
• W3105656181 cites W2054275187 @default.
• W3105656181 cites W2056997870 @default.
• W3105656181 cites W2059694087 @default.
• W3105656181 cites W2078059415 @default.
• W3105656181 cites W2078081719 @default.
• W3105656181 cites W2080812145 @default.
• W3105656181 cites W2092687362 @default.
• W3105656181 cites W2102619694 @default.
• W3105656181 cites W2108150032 @default.
• W3105656181 cites W2113748689 @default.
• W3105656181 cites W2114709909 @default.
• W3105656181 cites W2115717891 @default.
• W3105656181 cites W2117792884 @default.
• W3105656181 cites W2123564569 @default.
• W3105656181 cites W2124985265 @default.
• W3105656181 cites W2150089516 @default.
• W3105656181 cites W2150565403 @default.
• W3105656181 cites W2151754128 @default.
• W3105656181 cites W2152014285 @default.
• W3105656181 cites W2152642144 @default.
• W3105656181 cites W2157009395 @default.
• W3105656181 cites W2157952888 @default.
• W3105656181 cites W2171808845 @default.
• W3105656181 cites W2172368992 @default.
• W3105656181 cites W2177146256 @default.
• W3105656181 cites W2237299736 @default.
• W3105656181 cites W2510972801 @default.
• W3105656181 cites W2576162457 @default.
• W3105656181 cites W2581209098 @default.
• W3105656181 cites W2594621310 @default.
• W3105656181 cites W2612830428 @default.
• W3105656181 cites W2757704052 @default.
• W3105656181 cites W2759615793 @default.
• W3105656181 cites W2766617104 @default.
• W3105656181 cites W2767960938 @default.
• W3105656181 cites W2775154594 @default.
• W3105656181 cites W2883810206 @default.
• W3105656181 cites W2891784150 @default.
• W3105656181 cites W2909412037 @default.
• W3105656181 cites W2920418566 @default.
• W3105656181 cites W2950338203 @default.
• W3105656181 cites W2951270532 @default.
• W3105656181 cites W2956118984 @default.
• W3105656181 hasPublicationYear "2019" @default.
• W3105656181 type Work @default.
• W3105656181 sameAs 3105656181 @default.
• W3105656181 citedByCount "0" @default.
• W3105656181 crossrefType "posted-content" @default.
• W3105656181 hasAuthorship W3105656181A5007489515 @default.
• W3105656181 hasAuthorship W3105656181A5019584451 @default.
• W3105656181 hasAuthorship W3105656181A5022326820 @default.
• W3105656181 hasAuthorship W3105656181A5036601296 @default.
• W3105656181 hasAuthorship W3105656181A5041943054 @default.
• W3105656181 hasAuthorship W3105656181A5050964355 @default.
• W3105656181 hasAuthorship W3105656181A5051892257 @default.
• W3105656181 hasAuthorship W3105656181A5053397369 @default.
• W3105656181 hasAuthorship W3105656181A5060720882 @default.
• W3105656181 hasAuthorship W3105656181A5063040246 @default.
• W3105656181 hasAuthorship W3105656181A5066263942 @default.
• W3105656181 hasAuthorship W3105656181A5070141978 @default.
• W3105656181 hasAuthorship W3105656181A5084612869 @default.
• W3105656181 hasAuthorship W3105656181A5090246550 @default.
• W3105656181 hasConcept C101762097 @default.

• next