Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105698985> ?p ?o ?g. }
- W3105698985 abstract "Assembly of extracellular filaments and matrices mediating fundamental biological processes such as morphogenesis, hearing, fertilization, and antibacterial defense is driven by a ubiquitous polymerization module known as zona pellucida (ZP) domain. Despite the conservation of this element from hydra to humans, no detailed information is available on the filamentous conformation of any ZP module protein. Here, we report a cryo-electron microscopy study of uromodulin (UMOD)/Tamm-Horsfall protein, the most abundant protein in human urine and an archetypal ZP module-containing molecule, in its mature homopolymeric state. UMOD forms a one-start helix with an unprecedented 180-degree twist between subunits enfolded by interdomain linkers that have completely reorganized as a result of propeptide dissociation. Lateral interaction between filaments in the urine generates sheets exposing a checkerboard of binding sites to capture uropathogenic bacteria, and UMOD-based models of heteromeric vertebrate egg coat filaments identify a common sperm-binding region at the interface between subunits." @default.
- W3105698985 created "2020-11-23" @default.
- W3105698985 creator A5014682104 @default.
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- W3105698985 creator A5088193672 @default.
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- W3105698985 creator A5089155180 @default.
- W3105698985 date "2020-11-16" @default.
- W3105698985 modified "2023-10-01" @default.
- W3105698985 title "Cryo‐EM structure of native human uromodulin, a zona pellucida module polymer" @default.
- W3105698985 cites W1187728706 @default.
- W3105698985 cites W1494884984 @default.
- W3105698985 cites W1616509154 @default.
- W3105698985 cites W1838872057 @default.
- W3105698985 cites W1926927315 @default.
- W3105698985 cites W1965581896 @default.
- W3105698985 cites W1967730128 @default.
- W3105698985 cites W1969365560 @default.
- W3105698985 cites W1977188081 @default.
- W3105698985 cites W1989409094 @default.
- W3105698985 cites W1993059461 @default.
- W3105698985 cites W1995383525 @default.
- W3105698985 cites W1996380673 @default.
- W3105698985 cites W2001712372 @default.
- W3105698985 cites W2005038934 @default.
- W3105698985 cites W2008084413 @default.
- W3105698985 cites W2011298936 @default.
- W3105698985 cites W2015245776 @default.
- W3105698985 cites W2016105914 @default.
- W3105698985 cites W2022548242 @default.
- W3105698985 cites W2024869990 @default.
- W3105698985 cites W2026486120 @default.
- W3105698985 cites W2035503835 @default.
- W3105698985 cites W2076244281 @default.
- W3105698985 cites W2079331123 @default.
- W3105698985 cites W2081849640 @default.
- W3105698985 cites W2083231458 @default.
- W3105698985 cites W2086671921 @default.
- W3105698985 cites W2086812659 @default.
- W3105698985 cites W2089140462 @default.
- W3105698985 cites W2094458603 @default.
- W3105698985 cites W2094922355 @default.
- W3105698985 cites W2100455255 @default.
- W3105698985 cites W2104847673 @default.
- W3105698985 cites W2108588173 @default.
- W3105698985 cites W2108627006 @default.
- W3105698985 cites W2110869427 @default.
- W3105698985 cites W2112761498 @default.
- W3105698985 cites W2115167726 @default.
- W3105698985 cites W2128384816 @default.
- W3105698985 cites W2132629607 @default.
- W3105698985 cites W2135489883 @default.
- W3105698985 cites W2140355814 @default.
- W3105698985 cites W2141920771 @default.
- W3105698985 cites W2148308568 @default.
- W3105698985 cites W2149561246 @default.
- W3105698985 cites W2149574286 @default.
- W3105698985 cites W2153214460 @default.
- W3105698985 cites W2165144969 @default.
- W3105698985 cites W2166304117 @default.
- W3105698985 cites W2167279371 @default.
- W3105698985 cites W2171122741 @default.
- W3105698985 cites W2180357575 @default.
- W3105698985 cites W2196647469 @default.
- W3105698985 cites W2263502853 @default.
- W3105698985 cites W2286444875 @default.
- W3105698985 cites W2288386302 @default.
- W3105698985 cites W2324655178 @default.
- W3105698985 cites W2340685884 @default.
- W3105698985 cites W2376573086 @default.
- W3105698985 cites W2475658075 @default.
- W3105698985 cites W2593511418 @default.
- W3105698985 cites W2619218450 @default.
- W3105698985 cites W2620712420 @default.
- W3105698985 cites W2625468998 @default.
- W3105698985 cites W2731784911 @default.
- W3105698985 cites W2734356283 @default.
- W3105698985 cites W2742865474 @default.
- W3105698985 cites W2753536711 @default.
- W3105698985 cites W2765322245 @default.
- W3105698985 cites W2769466539 @default.
- W3105698985 cites W2774178591 @default.
- W3105698985 cites W2786390877 @default.
- W3105698985 cites W2788833468 @default.
- W3105698985 cites W2790953202 @default.
- W3105698985 cites W2791670278 @default.
- W3105698985 cites W2795673173 @default.
- W3105698985 cites W2800846715 @default.
- W3105698985 cites W2801376357 @default.
- W3105698985 cites W2888140967 @default.
- W3105698985 cites W2898402099 @default.
- W3105698985 cites W2899714098 @default.