FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105707952> ?p ?o ?g. }

• W3105707952 endingPage "e0241565" @default.
• W3105707952 startingPage "e0241565" @default.
• W3105707952 abstract "Background The cerebral thrombin system is activated in the early stage after intracerebral hemorrhage (ICH). Expression of thrombin leads to concentration dependent secondary neuronal damage and detrimental neurological outcome. In this study we aimed to investigate the impact of thrombin concentration and activity in the cerebrospinal fluid (CSF) of patients with ICH on clinical outcome. Methods Patients presenting with space-occupying lobar supratentorial hemorrhage requiring extra-ventricular drainage (EVD) were included in our study. The CSF levels of thrombin, its precursor prothrombin and the Thrombin-Antithrombin complex (TAT) were measured using enzyme linked immune sorbent assays (ELISA). The oxidative stress marker Superoxide dismutase (SOD) was assessed in CSF. Initial clot size and intraventricular hemorrhage (IVH) volume was calculated based on by computerized tomography (CT) upon admission to our hospital. Demographic data, clinical status at admission and neurological outcome were assessed using the modified Rankin Scale (mRS) at 6-weeks and 6-month after ICH. Results Twenty-two consecutive patients (9 females, 11 males) with supratentorial hemorrhage were included in this study. CSF concentrations of prothrombin (p < 0.005), thrombin (p = 0.005) and TAT (p = 0.046) were statistical significantly different in patients with ICH compared to non-hemorrhagic CSF samples. CSF concentrations of thrombin 24h after ICH correlated with the mRS index after 6 weeks (r 2 = 0.73; < 0.005) and 6 months (r 2 = 0.63; < 0.005) after discharge from hospital. Thrombin activity, measured via TAT as surrogate parameter of coagulation, likewise correlated with the mRS at 6 weeks (r 2 = 0.54; < 0.01) and 6 months (r 2 = 0.66; < 0.04). High thrombin concentrations coincide with higher SOD levels 24h after ICH (p = 0.01). Conclusion In this study we found that initial thrombin concentration and activity in CSF of ICH patients did not correlate with ICH and IVH volume but are associated with a poorer functional neurological outcome. These findings support mounting evidence of the role of thrombin as a contributor to secondary injury formation after ICH." @default.
• W3105707952 created "2020-11-23" @default.
• W3105707952 creator A5007692293 @default.
• W3105707952 creator A5017874967 @default.
• W3105707952 creator A5041220094 @default.
• W3105707952 creator A5052731938 @default.
• W3105707952 creator A5058697846 @default.
• W3105707952 creator A5066353777 @default.
• W3105707952 creator A5070107373 @default.
• W3105707952 creator A5074753668 @default.
• W3105707952 creator A5078759014 @default.
• W3105707952 creator A5083498484 @default.
• W3105707952 creator A5086608452 @default.
• W3105707952 date "2020-11-11" @default.
• W3105707952 modified "2023-09-25" @default.
• W3105707952 title "High CSF thrombin concentration and activity is associated with an unfavorable outcome in patients with intracerebral hemorrhage" @default.
• W3105707952 cites W101888782 @default.
• W3105707952 cites W1493302215 @default.
• W3105707952 cites W1594129908 @default.
• W3105707952 cites W1898124565 @default.
• W3105707952 cites W1963938486 @default.
• W3105707952 cites W1970301215 @default.
• W3105707952 cites W1970764391 @default.
• W3105707952 cites W1987656514 @default.
• W3105707952 cites W1990764815 @default.
• W3105707952 cites W2031850340 @default.
• W3105707952 cites W2038165542 @default.
• W3105707952 cites W2052119252 @default.
• W3105707952 cites W2053466751 @default.
• W3105707952 cites W2079080506 @default.
• W3105707952 cites W2092501769 @default.
• W3105707952 cites W2143007399 @default.
• W3105707952 cites W2159231976 @default.
• W3105707952 cites W2172105853 @default.
• W3105707952 cites W2330235342 @default.
• W3105707952 cites W2467347786 @default.
• W3105707952 cites W2885485060 @default.
• W3105707952 cites W2940545442 @default.
• W3105707952 cites W4210987237 @default.
• W3105707952 doi "https://doi.org/10.1371/journal.pone.0241565" @default.
• W3105707952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7657554" @default.
• W3105707952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33175864" @default.
• W3105707952 hasPublicationYear "2020" @default.
• W3105707952 type Work @default.
• W3105707952 sameAs 3105707952 @default.
• W3105707952 citedByCount "7" @default.
• W3105707952 countsByYear W31057079522021 @default.
• W3105707952 countsByYear W31057079522022 @default.
• W3105707952 countsByYear W31057079522023 @default.
• W3105707952 crossrefType "journal-article" @default.
• W3105707952 hasAuthorship W3105707952A5007692293 @default.
• W3105707952 hasAuthorship W3105707952A5017874967 @default.
• W3105707952 hasAuthorship W3105707952A5041220094 @default.
• W3105707952 hasAuthorship W3105707952A5052731938 @default.
• W3105707952 hasAuthorship W3105707952A5058697846 @default.
• W3105707952 hasAuthorship W3105707952A5066353777 @default.
• W3105707952 hasAuthorship W3105707952A5070107373 @default.
• W3105707952 hasAuthorship W3105707952A5074753668 @default.
• W3105707952 hasAuthorship W3105707952A5078759014 @default.
• W3105707952 hasAuthorship W3105707952A5083498484 @default.
• W3105707952 hasAuthorship W3105707952A5086608452 @default.
• W3105707952 hasBestOaLocation W31057079521 @default.
• W3105707952 hasConcept C126322002 @default.
• W3105707952 hasConcept C141341695 @default.
• W3105707952 hasConcept C17624336 @default.
• W3105707952 hasConcept C2777094939 @default.
• W3105707952 hasConcept C2777292125 @default.
• W3105707952 hasConcept C2778376644 @default.
• W3105707952 hasConcept C2779234561 @default.
• W3105707952 hasConcept C2779252433 @default.
• W3105707952 hasConcept C2779651940 @default.
• W3105707952 hasConcept C2780931571 @default.
• W3105707952 hasConcept C3020199598 @default.
• W3105707952 hasConcept C42219234 @default.
• W3105707952 hasConcept C541997718 @default.
• W3105707952 hasConcept C54355233 @default.
• W3105707952 hasConcept C71924100 @default.
• W3105707952 hasConcept C86803240 @default.
• W3105707952 hasConcept C89560881 @default.
• W3105707952 hasConcept C90924648 @default.
• W3105707952 hasConceptScore W3105707952C126322002 @default.
• W3105707952 hasConceptScore W3105707952C141341695 @default.
• W3105707952 hasConceptScore W3105707952C17624336 @default.
• W3105707952 hasConceptScore W3105707952C2777094939 @default.
• W3105707952 hasConceptScore W3105707952C2777292125 @default.
• W3105707952 hasConceptScore W3105707952C2778376644 @default.
• W3105707952 hasConceptScore W3105707952C2779234561 @default.
• W3105707952 hasConceptScore W3105707952C2779252433 @default.
• W3105707952 hasConceptScore W3105707952C2779651940 @default.
• W3105707952 hasConceptScore W3105707952C2780931571 @default.
• W3105707952 hasConceptScore W3105707952C3020199598 @default.
• W3105707952 hasConceptScore W3105707952C42219234 @default.
• W3105707952 hasConceptScore W3105707952C541997718 @default.
• W3105707952 hasConceptScore W3105707952C54355233 @default.
• W3105707952 hasConceptScore W3105707952C71924100 @default.
• W3105707952 hasConceptScore W3105707952C86803240 @default.
• W3105707952 hasConceptScore W3105707952C89560881 @default.
• W3105707952 hasConceptScore W3105707952C90924648 @default.

• next