Matches in SemOpenAlex for { <https://semopenalex.org/work/W3105719693> ?p ?o ?g. }
- W3105719693 abstract "SUMMARY Transcriptional profiling has revealed a diverse range of cancer cell states, however an understanding of their function has remained elusive. Using a combination of zebrafish melanoma modeling and human validation, we have identified a conserved stress-like state that confers intrinsic drug resistance. The stress-like state expresses genes such as fos , hsp70 and ubb , all required for adaptation to diverse cellular stresses, and we confirmed its existence using immunofluorescence and spatial transcriptomics. We provide evidence that this state has a higher tumor seeding capabilities compared to non-stressed cells, and confers intrinsic resistance to MEK inhibitors, a commonly used melanoma therapeutic. Furthermore, the stress-like program can be induced by extrinsic processes such as heat shock, and confers resistance to both MEK and BRAF inhibitors in both zebrafish and human melanomas. Collectively, our study suggests that the transcriptional states associated with therapeutic failure are established during the earliest steps of tumorigenesis." @default.
- W3105719693 created "2020-11-23" @default.
- W3105719693 creator A5003732636 @default.
- W3105719693 creator A5011493408 @default.
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- W3105719693 creator A5059804973 @default.
- W3105719693 creator A5069598030 @default.
- W3105719693 creator A5086627396 @default.
- W3105719693 date "2018-08-22" @default.
- W3105719693 modified "2023-10-06" @default.
- W3105719693 title "A population of stress-like cancer cells in melanoma promotes tumorigenesis and confers drug resistance" @default.
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