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• W3105724871 endingPage "111719" @default.
• W3105724871 startingPage "111719" @default.
• W3105724871 abstract "This study introduces a mesoporous magnetic nano-system for the delivery of apigenin (API). A targeted therapeutic drug delivery system was prepared based on Fe 2 O 3 /Fe 3 O 4 @mSiO 2 -HA nanocomposites. Magnetic Fe 2 O 3 /Fe 3 O 4 heterogeneous nanoparticles were first prepared via the rapid-combustion process. The effects of solvent type, solvent volume, calcination temperature, and calcination time on the crystal size and magnetism of the Fe 2 O 3 /Fe 3 O 4 heterogeneous nanoparticles were investigated. The mesoporous silica shell was deposited on the Fe 2 O 3 /Fe 3 O 4 heterogeneous nanoparticles using an improved Stöber method. HA was exploited as the targeting ligand. The specific surface area of the Fe 2 O 3 /Fe 3 O 4 @mSiO 2 nanocomposites was 369.6 m 2 /g, which is 19 times higher than that of the magnetic Fe 2 O 3 /Fe 3 O 4 heterogeneous nanoparticle cores. Drug release properties from the Fe 2 O 3 /Fe 3 O 4 @mSiO 2 -HA nanocomposites were studied, and the result showed that API-loaded nano-system had sustained release effect. Prussian blue staining and electrochemical performance variation showed that an external magnetic field facilitated cell uptake of Fe 2 O 3 /Fe 3 O 4 @mSiO 2 -HA nanocomposites. MTT assays showed that the cell inhibition effect of API-Fe 2 O 3 /Fe 3 O 4 @mSiO 2 -HA was stronger than that of free API at the same drug dose under a magnetic field and Fe 2 O 3 /Fe 3 O 4 @mSiO 2 -HA nanocomposites showed good biocompatibility. Fluorescence imaging, flow cytometry, western blot, reactive oxygen species (ROS), Superoxide dismutase (SOD) and malondialdehyde (MDA) kits verified that the enhanced therapeutic action was due to the promotion of apoptosis, lipid peroxidation, and ferroptosis. The magnetic nano-system (Fe 2 O 3 /Fe 3 O 4 @mSiO 2 -HA) showed good magnetic targeting and active hyaluronic acid targeting, and has the potential to provide a targeted delivery platform for many antitumor drugs. A novel magnetic drug loading system API-Fe 2 O 3 /Fe 3 O 4 @mSiO 2 -HA for the targeted delivery of apigenin (API), the biocompatibility of the blank nanocarriers and the targeting effect of API-Fe 2 O 3 /Fe 3 O 4 @mSiO 2 -HA were investigated by in vitro cytotoxicity (MTT assay), Prussian blue staining, and electrochemistry. Fluorescence microscopy, flow cytometry, scratch testing, and western blot were conducted to probe the apoptosis and the ferroptosis mechanism of API-Fe 2 O 3 /Fe 3 O 4 @mSiO 2 -HA in lung tumor A549 cells. • The novel magnetic Fe 2 O 3 /Fe 3 O 4 @mSiO 2 nanocomposites were fabricated. • A delivery system of apigenin loaded on Fe 2 O 3 /Fe 3 O 4 @mSiO 2 nanocomposites was constructed. • The antitumor mechanism of the system to A549 cells was exposed." @default.
• W3105724871 created "2020-11-23" @default.
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• W3105724871 creator A5090068965 @default.
• W3105724871 date "2021-01-01" @default.
• W3105724871 modified "2023-10-15" @default.
• W3105724871 title "Delivery of apigenin-loaded magnetic Fe2O3/Fe3O4@mSiO2 nanocomposites to A549 cells and their antitumor mechanism" @default.
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• W3105724871 doi "https://doi.org/10.1016/j.msec.2020.111719" @default.
• W3105724871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33545870" @default.
• W3105724871 hasPublicationYear "2021" @default.
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