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- W3105800833 abstract "Myeloid-derived suppressor cells (MDSCs) is a heterogenous cell population, consisting of myeloid progenitor cells and immature myeloid cells and having an ability to suppress T-cell function. Due to their suppressive effects on immunity, MDSCs can lead to facilitate tumor development and growth, and has been known to be associated with poor prognosis in various solid cancers. However, the role of MDSC in myeloid neoplasm are unclear. So, we elucidated the role of leukemic subpopulation showing CD11b＋CD33＋HLA-DR- immunophenotype, which resembles MDSCs. CD11b＋CD33＋HLA-DR- blast were isolated using flow-cytometry from bone marrow mononuclear cell sample, which were collected at the time of diagnosis by Acute Leukemia Cohort Study in Severance. The clinical impact of MDSC-like blasts was retrospectively reviewed in 63 patients. CD33＋HLA-DR- leukemic cells from each patients showed various range of expression for CD11b (Mean±SD, 21.02±22.19%). MDSCs can be divided into two subtypes, monocytic MDSC expressing CD14 and granulocytic MDSC expressing CD15, and CD14 expression on MDSC-like blast expression was more frequent than CD15 expression (67.5% vs. 39.3%). To figure out the immunosuppressive activity in MDSC-like blasts, Arg1 and iNOS expression were checked, and MDSC-like blasts showed significantly higher expression of Ara1(77.1% vs. 38.5%, p＜0.001) and iNOS (33.0% vs. 1.1%, p＜0.0001) compared to non-MDSC-like blasts. Compared to ‘Lower MDSC group’, WBC count, serum LDH, fraction of blasts in bone marrow, and frequency of adverse cytogenetics were significantly higher in ‘Higher MDSC group’. Patients in ‘High MDSC group’ had significantly shorter overall survival (331±42 vs. 758±114 days, p＝0.027). On multivariate analysis, higher fraction of CD11b＋CD33＋HLA-DR- leukemic cells (HR 2.966, 95%CI 1.086-8.095, p＝0.034), old age (p＝0.001), adverse cytogenetics (p＝0.013), and FAB classification (p＝0.035) were poor prognosis factors. CD33＋HLA-DR- MDSC-like blasts subgroup is existed in myeloid leukemic blasts with various range. Because they suppressed T cell immunity, also showed adverse prognostic effect on survival, MDSC-like blasts might play a certain role in immune-tolerance in leukemia." @default.
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- W3105800833 date "2016-01-01" @default.
- W3105800833 modified "2023-09-25" @default.
- W3105800833 title "S-567 The role and significance of MDSC-like myeloid blasts in immune-tolerance of AML" @default.
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