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• W3105909594 startingPage "1247" @default.
• W3105909594 abstract "Deregulation of protein synthesis may be involved in multiple aspects of cancer, such as gene expression, signal transduction and drive specific cell biological responses, resulting in promoting cancer growth, invasion and metastasis. Study the molecular mechanisms about translational control may help us to find more effective anti-cancer drugs and develop novel therapeutic opportunities. Recently, the researchers had focused on targeting translational machinery to overcome cancer, and various small molecular inhibitors targeting translation factors or pathways have been tested in clinical trials and exhibited improving outcomes in several cancer types. There is no doubt that an insight into the class of translation regulation protein would provide new target for pharmacologic intervention and further provide opportunities to develop novel anti-tumor therapeutic interventions. In this review, we summarized the developments of translational control in cancer survival and progression et al, and highlighted the therapeutic approach targeted translation regulation to overcome the cancer." @default.
• W3105909594 created "2020-11-23" @default.
• W3105909594 creator A5002608004 @default.
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• W3105909594 creator A5063346114 @default.
• W3105909594 creator A5075883718 @default.
• W3105909594 creator A5077022889 @default.
• W3105909594 date "2021-01-01" @default.
• W3105909594 modified "2023-09-24" @default.
• W3105909594 title "Targeting translation regulators improves cancer therapy" @default.
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