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- W3105919133 endingPage "12787" @default.
- W3105919133 startingPage "12757" @default.
- W3105919133 abstract "Our understanding of lipid peroxidation in biology and medicine is rapidly evolving, as it is increasingly implicated in various diseases but also recognized as a key part of normal cell function, signaling, and death (ferroptosis). Not surprisingly, the root and consequences of lipid peroxidation have garnered increasing attention from multiple disciplines in recent years. Here we “connect the dots” between the fundamental chemistry underpinning the cascade reactions of lipid peroxidation (enzymatic or free radical), the reactive nature of the products formed (lipid-derived electrophiles), and the biological targets and mechanisms associated with these products that culminate in cellular responses. We additionally bring light to the use of highly sensitive, fluorescence-based methodologies. Stemming from the foundational concepts in chemistry and biology, these methodologies enable visualizing and quantifying each reaction in the cascade in a cellular and ultimately tissue context, toward deciphering the connections between the chemistry and physiology of lipid peroxidation. The review offers a platform in which the chemistry and biomedical research communities can access a comprehensive summary of fundamental concepts regarding lipid peroxidation, experimental tools for the study of such processes, as well as the recent discoveries by leading investigators with an emphasis on significant open questions." @default.
- W3105919133 created "2020-11-23" @default.
- W3105919133 creator A5033125462 @default.
- W3105919133 creator A5036484954 @default.
- W3105919133 creator A5042478595 @default.
- W3105919133 creator A5062227991 @default.
- W3105919133 creator A5068686546 @default.
- W3105919133 date "2020-11-19" @default.
- W3105919133 modified "2023-10-14" @default.
- W3105919133 title "Connecting the “Dots”: From Free Radical Lipid Autoxidation to Cell Pathology and Disease" @default.
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