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- W3106005993 abstract "Bile acids (BAs) regulate dietary lipid hydrolysis and absorption in the proximal intestine. Several studies have highlighted a determinant role of circulating levels and/or metabolism of BAs in the pathogenesis of major cardiometabolic diseases. Whether changes in BA profiles are causative or are consequence of these diseases remains to be determined. Healthy male volunteers (n = 71) underwent a postprandial exploration following consumption of a hypercaloric high fat typical Western meal providing 1200 kcal. We investigated variations of circulating levels of 28 BA species, together with BA synthesis marker 7α-hydroxy-4-cholesten-3-one (C4) over an approximately diurnal 12 h period. Analysis of BA variations during the postprandial time course revealed two major phenotypes with opposite fluctuations, i.e., circulating levels of each individual species of unconjugated BAs were reduced after meal consumption whereas those of tauro- and glyco-conjugated BAs were increased. By an unbiased classification strategy based on absolute postprandial changes in BA species levels, we classified subjects into three distinct clusters; the two extreme clusters being characterized by the smallest absolute changes in either unconjugated-BAs or conjugated-BAs. Finally, we demonstrated that our clustering based on postprandial changes in BA profiles was associated with specific clinical and biochemical features, including postprandial triglyceride levels, BMI or waist circumference. Altogether, our study reveals that postprandial profiles/patterns of BAs in response to a hypercaloric high fat challenge is associated with healthy or unhealthy metabolic phenotypes that may help in the early identification of subjects at risk of developing metabolic disorders." @default.
- W3106005993 created "2020-11-23" @default.
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- W3106005993 date "2020-11-19" @default.
- W3106005993 modified "2023-10-16" @default.
- W3106005993 title "Distinct Postprandial Bile Acids Responses to a High-Calorie Diet in Men Volunteers Underscore Metabolically Healthy and Unhealthy Phenotypes" @default.
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- W3106005993 cites W1499580210 @default.
- W3106005993 cites W1729384866 @default.
- W3106005993 cites W1832709945 @default.
- W3106005993 cites W1963587340 @default.
- W3106005993 cites W1966922165 @default.
- W3106005993 cites W1969468438 @default.
- W3106005993 cites W1977106726 @default.
- W3106005993 cites W1979308600 @default.
- W3106005993 cites W1979700533 @default.
- W3106005993 cites W1980300504 @default.
- W3106005993 cites W1994413837 @default.
- W3106005993 cites W1995492187 @default.
- W3106005993 cites W1996559176 @default.
- W3106005993 cites W2008713279 @default.
- W3106005993 cites W2009938384 @default.
- W3106005993 cites W2010574468 @default.
- W3106005993 cites W2021206718 @default.
- W3106005993 cites W2021444563 @default.
- W3106005993 cites W2023733316 @default.
- W3106005993 cites W2041335894 @default.
- W3106005993 cites W2049506766 @default.
- W3106005993 cites W2053581007 @default.
- W3106005993 cites W2070737616 @default.
- W3106005993 cites W2078036674 @default.
- W3106005993 cites W2078810890 @default.
- W3106005993 cites W2092164296 @default.
- W3106005993 cites W2094290879 @default.
- W3106005993 cites W2096418655 @default.
- W3106005993 cites W2099673318 @default.
- W3106005993 cites W2113253151 @default.
- W3106005993 cites W2123561714 @default.
- W3106005993 cites W2127567473 @default.
- W3106005993 cites W2131184144 @default.
- W3106005993 cites W2131891210 @default.
- W3106005993 cites W2157937853 @default.
- W3106005993 cites W2159007574 @default.
- W3106005993 cites W2171398834 @default.
- W3106005993 cites W2199066586 @default.
- W3106005993 cites W2208262108 @default.
- W3106005993 cites W2255310484 @default.
- W3106005993 cites W2314167679 @default.
- W3106005993 cites W2316224242 @default.
- W3106005993 cites W2336536891 @default.
- W3106005993 cites W2418348567 @default.
- W3106005993 cites W2464914283 @default.
- W3106005993 cites W2557764746 @default.
- W3106005993 cites W2561503172 @default.
- W3106005993 cites W2604117018 @default.
- W3106005993 cites W2613113252 @default.
- W3106005993 cites W2691396703 @default.
- W3106005993 cites W2733373093 @default.
- W3106005993 cites W2768705126 @default.
- W3106005993 cites W2783048272 @default.
- W3106005993 cites W2793943052 @default.
- W3106005993 cites W2803036262 @default.
- W3106005993 cites W2806418901 @default.
- W3106005993 cites W2810932369 @default.
- W3106005993 cites W2897155619 @default.
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- W3106005993 cites W2975185045 @default.
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- W3106005993 doi "https://doi.org/10.3390/nu12113545" @default.
- W3106005993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7699492" @default.
- W3106005993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33228154" @default.
- W3106005993 hasPublicationYear "2020" @default.
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