Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106026989> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3106026989 abstract "Cardiac progenitor cells (CPCs) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo immune response to transplanted adult CPCs (aCPCs) reduces cell retention and MI recovery. We aimed to increase the regenerative potential of aCPCs by reducing immune response directed to the transplanted aCPCs using cyclosporine A (CsA). Adult CPCs isolated from Wister Kyoto rat was transplanted into Brown Norway MI rats. MI rats transplanted with aCPCs+CsA demonstrated significant increase in MI recovery and cell retention compared to MI rats with aCPCs, CsA and Iscove Modified Dulbecco Media controls (p<0.05). MI rats transplanted with aCPCs showed increased infiltration of CD68 + cells and apoptotic cells in the infarcted myocardium compared to aCPCs+CsA group (p<0.05) analyzed by immunohistochemistry. Sera collected on day 2 and 7 of aCPCs group showed increased inflammatory cytokines (IL-2, IL-17, IFN-γ, TGF-β), antibodies to cardiac SAgs (Troponin-T and Myosin) allo antigens (RT1A, RT1B and RT1D) and reduced anti-inflammatory cytokines (IL-10). In contrast MI rats transplanted with aCPCs+CsA showed reduced inflammatory cytokines, abs to SAgs, allo antigens and increased anti-inflammatory cytokine IL-10 (p<0.05). In conclusion, MI rats transplanted with allogeneic aCPCs with immune suppressant CsA showed increased cell retention, reduced inflammatory cells and cytokines compared to aCPCs, CsA and IMDM control. Therefore, CsA reduces auto and allo immune response and increases regeneration potential by increased transplanted aCPCs retention that resulted in enhanced myocardial recovery." @default.
- W3106026989 created "2020-11-23" @default.
- W3106026989 creator A5000641278 @default.
- W3106026989 creator A5004685955 @default.
- W3106026989 creator A5012141584 @default.
- W3106026989 creator A5032745042 @default.
- W3106026989 creator A5037176827 @default.
- W3106026989 creator A5046946184 @default.
- W3106026989 creator A5048388773 @default.
- W3106026989 creator A5052651149 @default.
- W3106026989 creator A5058847058 @default.
- W3106026989 creator A5079838580 @default.
- W3106026989 date "2020-11-17" @default.
- W3106026989 modified "2023-09-23" @default.
- W3106026989 title "Abstract 16733: Immune Response Following Allogenic Cardiac Progenitor Cells Transplantation in Rat Myocardial Infarction Model" @default.
- W3106026989 doi "https://doi.org/10.1161/circ.142.suppl_3.16733" @default.
- W3106026989 hasPublicationYear "2020" @default.
- W3106026989 type Work @default.
- W3106026989 sameAs 3106026989 @default.
- W3106026989 citedByCount "0" @default.
- W3106026989 crossrefType "journal-article" @default.
- W3106026989 hasAuthorship W3106026989A5000641278 @default.
- W3106026989 hasAuthorship W3106026989A5004685955 @default.
- W3106026989 hasAuthorship W3106026989A5012141584 @default.
- W3106026989 hasAuthorship W3106026989A5032745042 @default.
- W3106026989 hasAuthorship W3106026989A5037176827 @default.
- W3106026989 hasAuthorship W3106026989A5046946184 @default.
- W3106026989 hasAuthorship W3106026989A5048388773 @default.
- W3106026989 hasAuthorship W3106026989A5052651149 @default.
- W3106026989 hasAuthorship W3106026989A5058847058 @default.
- W3106026989 hasAuthorship W3106026989A5079838580 @default.
- W3106026989 hasConcept C126322002 @default.
- W3106026989 hasConcept C16685009 @default.
- W3106026989 hasConcept C201750760 @default.
- W3106026989 hasConcept C203014093 @default.
- W3106026989 hasConcept C204232928 @default.
- W3106026989 hasConcept C2776460901 @default.
- W3106026989 hasConcept C2778690821 @default.
- W3106026989 hasConcept C28328180 @default.
- W3106026989 hasConcept C2911091166 @default.
- W3106026989 hasConcept C71924100 @default.
- W3106026989 hasConcept C86803240 @default.
- W3106026989 hasConcept C8891405 @default.
- W3106026989 hasConcept C95444343 @default.
- W3106026989 hasConceptScore W3106026989C126322002 @default.
- W3106026989 hasConceptScore W3106026989C16685009 @default.
- W3106026989 hasConceptScore W3106026989C201750760 @default.
- W3106026989 hasConceptScore W3106026989C203014093 @default.
- W3106026989 hasConceptScore W3106026989C204232928 @default.
- W3106026989 hasConceptScore W3106026989C2776460901 @default.
- W3106026989 hasConceptScore W3106026989C2778690821 @default.
- W3106026989 hasConceptScore W3106026989C28328180 @default.
- W3106026989 hasConceptScore W3106026989C2911091166 @default.
- W3106026989 hasConceptScore W3106026989C71924100 @default.
- W3106026989 hasConceptScore W3106026989C86803240 @default.
- W3106026989 hasConceptScore W3106026989C8891405 @default.
- W3106026989 hasConceptScore W3106026989C95444343 @default.
- W3106026989 hasIssue "Suppl_3" @default.
- W3106026989 hasLocation W31060269891 @default.
- W3106026989 hasOpenAccess W3106026989 @default.
- W3106026989 hasPrimaryLocation W31060269891 @default.
- W3106026989 hasRelatedWork W181678093 @default.
- W3106026989 hasRelatedWork W1993985418 @default.
- W3106026989 hasRelatedWork W2005666125 @default.
- W3106026989 hasRelatedWork W2047209980 @default.
- W3106026989 hasRelatedWork W2095433947 @default.
- W3106026989 hasRelatedWork W3017248443 @default.
- W3106026989 hasRelatedWork W3185323772 @default.
- W3106026989 hasRelatedWork W2178696297 @default.
- W3106026989 hasRelatedWork W2185732136 @default.
- W3106026989 hasRelatedWork W2396811992 @default.
- W3106026989 hasVolume "142" @default.
- W3106026989 isParatext "false" @default.
- W3106026989 isRetracted "false" @default.
- W3106026989 magId "3106026989" @default.
- W3106026989 workType "article" @default.