Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106172110> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3106172110 abstract "Significant differences between men and women are observed in terms of prevalence to adrenal cortical diseases. In particular, women are up to 6 times more likely than men to develop tumors of the adrenal cortex. Despite those striking disparity, differences and similarities in adrenal cortex renewal between sexes have yet to be investigated. The adrenal gland is a vital organ maintaining body homeostasis through the secretion of steroid hormones. It is composed of two endocrine glands, the medulla and the cortex, that is further divided into concentric zones, from the outer to the inner: the zona glomerulosa, the zona fasciculata and a zona reticularis in human or an X-zone in mice. The cortex is surrounded by a capsule that is further enveloped by a layer of mesothelial cells. In the adult stage, the adrenal cortex undergoes constant cellular renewal. Progenitor cells, located in the outer cortex, proliferate and give rise to new steroidogenic cells that centripetally migrate within the cortex, transdifferentiating along the way until they reach the border with the medulla and enter into apoptosis. During my thesis, I have shown that cell renewal in the adrenal cortex is highly sexually dimorphic with the female cortex being fully replaced in less than 3 months, while in males tissue renewal takes about 9 months. In addition, while male cortical renewal relies on progenitors located in the zona glomerulosa, the female cortex also recruits cells from the capsule to replenish the steroidogenic cell population. Finally, using sex reversal mouse models, gonadectomy and dihytrotestosterone treatments, I have identified an inhibitory role of male androgens on the proliferation and recruitment of capsular cells. In parallel, I have also studied a mouse model ectopically expressing Rspo1 in steroidogenic cells. Careful analysis of this model has evidenced the development of cortical hyperplasia and tumors in aging mice, a phenotype that was found to be significantly more pronounced in female than male. In addition, while male adrenals show signs of cellular degeneration in the adrenal cortex as early as 6 weeks of age, this histology is only observed in females of 12 months of age. Together, these results highlight profound differences between male and female in tissue homeostasis and phenotype development. These differences could offer an explanation to the unequal prevalence to adrenal diseases in men and women." @default.
- W3106172110 created "2020-11-23" @default.
- W3106172110 creator A5030960545 @default.
- W3106172110 date "2019-04-16" @default.
- W3106172110 modified "2023-09-27" @default.
- W3106172110 title "The adrenal cortex exhibits sexually dimorphic tissue renewal and disease development" @default.
- W3106172110 hasPublicationYear "2019" @default.
- W3106172110 type Work @default.
- W3106172110 sameAs 3106172110 @default.
- W3106172110 citedByCount "0" @default.
- W3106172110 crossrefType "dissertation" @default.
- W3106172110 hasAuthorship W3106172110A5030960545 @default.
- W3106172110 hasConcept C105702510 @default.
- W3106172110 hasConcept C126322002 @default.
- W3106172110 hasConcept C134018914 @default.
- W3106172110 hasConcept C169760540 @default.
- W3106172110 hasConcept C17291353 @default.
- W3106172110 hasConcept C2777348757 @default.
- W3106172110 hasConcept C2777784954 @default.
- W3106172110 hasConcept C2777977426 @default.
- W3106172110 hasConcept C2778736161 @default.
- W3106172110 hasConcept C2780178468 @default.
- W3106172110 hasConcept C2908647359 @default.
- W3106172110 hasConcept C2908929049 @default.
- W3106172110 hasConcept C71924100 @default.
- W3106172110 hasConcept C84393581 @default.
- W3106172110 hasConcept C86803240 @default.
- W3106172110 hasConcept C99454951 @default.
- W3106172110 hasConceptScore W3106172110C105702510 @default.
- W3106172110 hasConceptScore W3106172110C126322002 @default.
- W3106172110 hasConceptScore W3106172110C134018914 @default.
- W3106172110 hasConceptScore W3106172110C169760540 @default.
- W3106172110 hasConceptScore W3106172110C17291353 @default.
- W3106172110 hasConceptScore W3106172110C2777348757 @default.
- W3106172110 hasConceptScore W3106172110C2777784954 @default.
- W3106172110 hasConceptScore W3106172110C2777977426 @default.
- W3106172110 hasConceptScore W3106172110C2778736161 @default.
- W3106172110 hasConceptScore W3106172110C2780178468 @default.
- W3106172110 hasConceptScore W3106172110C2908647359 @default.
- W3106172110 hasConceptScore W3106172110C2908929049 @default.
- W3106172110 hasConceptScore W3106172110C71924100 @default.
- W3106172110 hasConceptScore W3106172110C84393581 @default.
- W3106172110 hasConceptScore W3106172110C86803240 @default.
- W3106172110 hasConceptScore W3106172110C99454951 @default.
- W3106172110 hasLocation W31061721101 @default.
- W3106172110 hasOpenAccess W3106172110 @default.
- W3106172110 hasPrimaryLocation W31061721101 @default.
- W3106172110 hasRelatedWork W1966533874 @default.
- W3106172110 hasRelatedWork W1970774523 @default.
- W3106172110 hasRelatedWork W1986205831 @default.
- W3106172110 hasRelatedWork W1991692440 @default.
- W3106172110 hasRelatedWork W1998645985 @default.
- W3106172110 hasRelatedWork W2008157672 @default.
- W3106172110 hasRelatedWork W2020167610 @default.
- W3106172110 hasRelatedWork W2020883025 @default.
- W3106172110 hasRelatedWork W2038182432 @default.
- W3106172110 hasRelatedWork W2039413706 @default.
- W3106172110 hasRelatedWork W2058343088 @default.
- W3106172110 hasRelatedWork W2067724021 @default.
- W3106172110 hasRelatedWork W2067988614 @default.
- W3106172110 hasRelatedWork W2087096711 @default.
- W3106172110 hasRelatedWork W2584365334 @default.
- W3106172110 hasRelatedWork W2802139127 @default.
- W3106172110 hasRelatedWork W2947764786 @default.
- W3106172110 hasRelatedWork W2948435283 @default.
- W3106172110 hasRelatedWork W3045120467 @default.
- W3106172110 hasRelatedWork W3124662220 @default.
- W3106172110 isParatext "false" @default.
- W3106172110 isRetracted "false" @default.
- W3106172110 magId "3106172110" @default.
- W3106172110 workType "dissertation" @default.