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• W3106189782 abstract "Abstract Background and aims Pathological bacterial translocation (PBT) in liver cirrhosis (LC) is the hallmark for spontaneous bacterial infections increasing mortality several-fold. Factors known to contribute to PBT in LC are among others an increased intestinal permeability of which however, the mucus layer has not been addressed so far in detail. A clear route of translocation for luminal intestinal bacteria is yet to be defined but we hypothesize that the recently described gut vascular barrier (GVB) is impaired in experimental portal hypertension leading to increased accessibility of the vascular compartment for translocating bacteria. Results Healthy and pre-hepatic portal-hypertensive (PPVL) mice lack translocation of FITC-dextran and GFP- Escherichia coli from the small intestine to the liver whereas bile-duct-ligated (BDL) and CCl4-induced cirrhotic mice demonstrate pathological translocation which is not altered by prior thoracic-duct ligation. Mucus layer is reduced in thickness with loss of goblet-cells and Muc2-staining and expression in cirrhotic but not PPVL-mice associated with bacterial overgrowth in inner mucus layer and pathological translocation of GFP- E.coli through the ileal epithelium. GVB is profoundly altered in BDL and CCl4-mice with Ileal extravasation of large-sized 150 kDa-FITC-dextran but only minor in PPVL-mice. This pathological endothelial permeability and accessibility in cirrhotic mice associates with an augmented expression of PV1 in intestinal vessels. OCA but not fexaramine stabilizes the GVB whereas both FXR-agonists ameliorate gut-liver-translocation of GFP- E.coli . Conclusions Liver cirrhosis but not portal hypertension per se grossly impairs the endothelial and muco-epithelial barriers promoting PBT to the portal-venous circulation. Both barriers appear FXR-modulated with –agonists reducing PBT via the portal-venous route." @default.
• W3106189782 created "2020-11-23" @default.
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• W3106189782 date "2019-07-08" @default.
• W3106189782 modified "2023-10-15" @default.
• W3106189782 title "Intestinal mucus and gut-vascular barrier: FxR-modulated entry sites for pathological bacterial translocation in liver cirrhosis" @default.
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• W3106189782 cites W1974556922 @default.
• W3106189782 cites W1974616640 @default.
• W3106189782 cites W1976611079 @default.
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• W3106189782 cites W1992449311 @default.
• W3106189782 cites W199832027 @default.
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• W3106189782 cites W2044195919 @default.
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• W3106189782 cites W2049515100 @default.
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• W3106189782 cites W2067719505 @default.
• W3106189782 cites W2074432560 @default.
• W3106189782 cites W2082732215 @default.
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• W3106189782 cites W2104582722 @default.
• W3106189782 cites W2107051699 @default.
• W3106189782 cites W2107239589 @default.
• W3106189782 cites W2124347139 @default.
• W3106189782 cites W2127690112 @default.
• W3106189782 cites W2131655174 @default.
• W3106189782 cites W2132551814 @default.
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• W3106189782 cites W2136919496 @default.
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• W3106189782 doi "https://doi.org/10.1101/690057" @default.
• W3106189782 hasPublicationYear "2019" @default.
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