Matches in SemOpenAlex for { <https://semopenalex.org/work/W310619234> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W310619234 endingPage "89" @default.
- W310619234 startingPage "81" @default.
- W310619234 abstract "Objectives: In this study, the pharmacological effects of the ethylacetate extract of Ostericum koreanum(North Kangwhal; NK) on allergic inflammation were investigated in activated human mast cells. Methods: North Kangwhal was extracted with 80% methanol for 24 h, and then fractionated with ethylacetate(NK-EtOAc extract). HMC-1 cells, an human mast line, were pre-incubated with different concentrations of NK-EtOAc extract for 30 min, and then stimulated with PMA(50 nM/ml) and A23187() at indicated times. The cell toxicity was determined by MTT assay. The concentrations of prostaglandin E2(PGE2) and cytokines(TNF-, IL-8) were measured by enzyme-linked immunosorbant assay. Results: NK-EtOAc extract() significantly inhibited the productions of , TNF- and IL-8 in PMA/A23187-stimulated HMC-1 cells without cell toxicity(). NK-EtOAc extract also inhibited PMA/A23187-induced phosphorylation of ERK1/2 MAPK and the NF- p65 subunit translocation into the nuclear of HMC-1 cells. Conclusions: This study suggests that NK-EtOAc extract may have an anti-inflammatory property through suppressing the production of inflammatory mediators in activated mast cells and its molecular mechanism underlies the blocking of NF- pathway." @default.
- W310619234 created "2016-06-24" @default.
- W310619234 creator A5008205702 @default.
- W310619234 creator A5018228594 @default.
- W310619234 creator A5028535509 @default.
- W310619234 creator A5088825652 @default.
- W310619234 date "2008-01-01" @default.
- W310619234 modified "2023-09-24" @default.
- W310619234 title "The Ethylacetate Extract of North Kangwhal(Ostericum koreanum) Attenuates the Inflammatory Responses in PMA/A23187-stimulated Mast Cells" @default.
- W310619234 cites W1501213833 @default.
- W310619234 cites W1902755075 @default.
- W310619234 cites W2013392510 @default.
- W310619234 cites W2024273982 @default.
- W310619234 cites W2054172795 @default.
- W310619234 cites W2075256580 @default.
- W310619234 cites W2086475752 @default.
- W310619234 cites W2087947398 @default.
- W310619234 cites W2115444485 @default.
- W310619234 cites W2122376237 @default.
- W310619234 cites W2122666166 @default.
- W310619234 cites W2149250436 @default.
- W310619234 cites W2168907731 @default.
- W310619234 hasPublicationYear "2008" @default.
- W310619234 type Work @default.
- W310619234 sameAs 310619234 @default.
- W310619234 citedByCount "3" @default.
- W310619234 countsByYear W3106192342012 @default.
- W310619234 crossrefType "journal-article" @default.
- W310619234 hasAuthorship W310619234A5008205702 @default.
- W310619234 hasAuthorship W310619234A5018228594 @default.
- W310619234 hasAuthorship W310619234A5028535509 @default.
- W310619234 hasAuthorship W310619234A5088825652 @default.
- W310619234 hasConcept C11960822 @default.
- W310619234 hasConcept C134018914 @default.
- W310619234 hasConcept C1491633281 @default.
- W310619234 hasConcept C164027704 @default.
- W310619234 hasConcept C17991360 @default.
- W310619234 hasConcept C185592680 @default.
- W310619234 hasConcept C203014093 @default.
- W310619234 hasConcept C2776914184 @default.
- W310619234 hasConcept C2777198256 @default.
- W310619234 hasConcept C2777730290 @default.
- W310619234 hasConcept C2777956040 @default.
- W310619234 hasConcept C2779726688 @default.
- W310619234 hasConcept C2780783641 @default.
- W310619234 hasConcept C55493867 @default.
- W310619234 hasConcept C62478195 @default.
- W310619234 hasConcept C71924100 @default.
- W310619234 hasConcept C98274493 @default.
- W310619234 hasConceptScore W310619234C11960822 @default.
- W310619234 hasConceptScore W310619234C134018914 @default.
- W310619234 hasConceptScore W310619234C1491633281 @default.
- W310619234 hasConceptScore W310619234C164027704 @default.
- W310619234 hasConceptScore W310619234C17991360 @default.
- W310619234 hasConceptScore W310619234C185592680 @default.
- W310619234 hasConceptScore W310619234C203014093 @default.
- W310619234 hasConceptScore W310619234C2776914184 @default.
- W310619234 hasConceptScore W310619234C2777198256 @default.
- W310619234 hasConceptScore W310619234C2777730290 @default.
- W310619234 hasConceptScore W310619234C2777956040 @default.
- W310619234 hasConceptScore W310619234C2779726688 @default.
- W310619234 hasConceptScore W310619234C2780783641 @default.
- W310619234 hasConceptScore W310619234C55493867 @default.
- W310619234 hasConceptScore W310619234C62478195 @default.
- W310619234 hasConceptScore W310619234C71924100 @default.
- W310619234 hasConceptScore W310619234C98274493 @default.
- W310619234 hasIssue "4" @default.
- W310619234 hasLocation W3106192341 @default.
- W310619234 hasOpenAccess W310619234 @default.
- W310619234 hasPrimaryLocation W3106192341 @default.
- W310619234 hasRelatedWork W1964334815 @default.
- W310619234 hasRelatedWork W1966465758 @default.
- W310619234 hasRelatedWork W1983870170 @default.
- W310619234 hasRelatedWork W1994483653 @default.
- W310619234 hasRelatedWork W2033227273 @default.
- W310619234 hasRelatedWork W2043139559 @default.
- W310619234 hasRelatedWork W2059556076 @default.
- W310619234 hasRelatedWork W2188566211 @default.
- W310619234 hasRelatedWork W2256821004 @default.
- W310619234 hasRelatedWork W2381856670 @default.
- W310619234 hasRelatedWork W2398267032 @default.
- W310619234 hasRelatedWork W2401191618 @default.
- W310619234 hasRelatedWork W2581496864 @default.
- W310619234 hasRelatedWork W2737707281 @default.
- W310619234 hasRelatedWork W2993012616 @default.
- W310619234 hasRelatedWork W3121099636 @default.
- W310619234 hasRelatedWork W3123572436 @default.
- W310619234 hasRelatedWork W3160662316 @default.
- W310619234 hasRelatedWork W3162983712 @default.
- W310619234 hasRelatedWork W3181637927 @default.
- W310619234 hasVolume "23" @default.
- W310619234 isParatext "false" @default.
- W310619234 isRetracted "false" @default.
- W310619234 magId "310619234" @default.
- W310619234 workType "article" @default.