FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106314465> ?p ?o ?g. }

• W3106314465 abstract "Summary The outer membrane (OM) is an essential component of the Gram-negative bacterial envelope that protects cells against external threats. To maintain a functional OM, cells require distinct mechanisms to ensure balance of proteins and lipids in the membrane. Mutations in OM biogenesis and/or homeostasis pathways often result in permeability defects, but how molecular changes in the OM affect barrier function is unclear. Here, we seek potential mechanism(s) that can alleviate permeability defects in Escherichia coli cells lacking the Tol-Pal complex, which accumulate excess PLs in the OM. We identify mutations in enterobacterial common antigen (ECA) biosynthesis that re-establish OM barrier function against large hydrophilic molecules, yet did not restore lipid homeostasis. Furthermore, we demonstrate that build-up of biosynthetic intermediates, but not loss of ECA itself, contributes to the rescue. This suppression of OM phenotypes is unrelated to known effects that accumulation of ECA intermediates have on the cell wall. Finally, we reveal that an unusual diacylglycerol pyrophosphoryl-linked lipid species also accumulates in ECA mutants, and might play a role in the rescue phenotype. Our work provides insights into how OM barrier function can be restored independent of lipid homeostasis, and highlights previously unappreciated effects of ECA-related species in OM biology." @default.
• W3106314465 created "2020-11-23" @default.
• W3106314465 creator A5034794449 @default.
• W3106314465 creator A5048507138 @default.
• W3106314465 creator A5054276215 @default.
• W3106314465 creator A5061782485 @default.
• W3106314465 creator A5064971055 @default.
• W3106314465 creator A5071297179 @default.
• W3106314465 creator A5086636066 @default.
• W3106314465 date "2018-11-29" @default.
• W3106314465 modified "2023-10-16" @default.
• W3106314465 title "Mutations in enterobacterial common antigen biosynthesis restore outer membrane barrier function in<i>Escherichia coli tol-pal</i>mutants" @default.
• W3106314465 cites W1496556712 @default.
• W3106314465 cites W1529049904 @default.
• W3106314465 cites W1578177009 @default.
• W3106314465 cites W1580981982 @default.
• W3106314465 cites W1634139602 @default.
• W3106314465 cites W1706254951 @default.
• W3106314465 cites W1856284986 @default.
• W3106314465 cites W193673460 @default.
• W3106314465 cites W1964807436 @default.
• W3106314465 cites W1967725603 @default.
• W3106314465 cites W1968139814 @default.
• W3106314465 cites W1980613942 @default.
• W3106314465 cites W1990991313 @default.
• W3106314465 cites W2009716641 @default.
• W3106314465 cites W2014361215 @default.
• W3106314465 cites W2031726339 @default.
• W3106314465 cites W2038246976 @default.
• W3106314465 cites W2039276727 @default.
• W3106314465 cites W2042814467 @default.
• W3106314465 cites W2051119646 @default.
• W3106314465 cites W2084364436 @default.
• W3106314465 cites W2092648073 @default.
• W3106314465 cites W2099540110 @default.
• W3106314465 cites W2100837269 @default.
• W3106314465 cites W2101813599 @default.
• W3106314465 cites W2102948971 @default.
• W3106314465 cites W2103441770 @default.
• W3106314465 cites W2104944405 @default.
• W3106314465 cites W2105324903 @default.
• W3106314465 cites W2108608900 @default.
• W3106314465 cites W2109160052 @default.
• W3106314465 cites W2109624862 @default.
• W3106314465 cites W2111967267 @default.
• W3106314465 cites W2116137883 @default.
• W3106314465 cites W2120061656 @default.
• W3106314465 cites W2121085961 @default.
• W3106314465 cites W2132065459 @default.
• W3106314465 cites W2133152400 @default.
• W3106314465 cites W2139136118 @default.
• W3106314465 cites W2150010294 @default.
• W3106314465 cites W2152490783 @default.
• W3106314465 cites W2153461618 @default.
• W3106314465 cites W2157995916 @default.
• W3106314465 cites W2166642784 @default.
• W3106314465 cites W2166688100 @default.
• W3106314465 cites W2172112954 @default.
• W3106314465 cites W2174282801 @default.
• W3106314465 cites W2287479920 @default.
• W3106314465 cites W2314285321 @default.
• W3106314465 cites W2513199622 @default.
• W3106314465 cites W2515969082 @default.
• W3106314465 cites W2528034864 @default.
• W3106314465 cites W2605033818 @default.
• W3106314465 cites W2801467874 @default.
• W3106314465 cites W2884266059 @default.
• W3106314465 cites W2884934298 @default.
• W3106314465 cites W2887405283 @default.
• W3106314465 cites W2918045957 @default.
• W3106314465 cites W2933224571 @default.
• W3106314465 cites W2951960435 @default.
• W3106314465 cites W2952076908 @default.
• W3106314465 cites W2952579663 @default.
• W3106314465 cites W2968579141 @default.
• W3106314465 cites W2972392294 @default.
• W3106314465 cites W3010145555 @default.
• W3106314465 cites W4234317413 @default.
• W3106314465 doi "https://doi.org/10.1101/480533" @default.
• W3106314465 hasPublicationYear "2018" @default.
• W3106314465 type Work @default.
• W3106314465 sameAs 3106314465 @default.
• W3106314465 citedByCount "0" @default.
• W3106314465 crossrefType "posted-content" @default.
• W3106314465 hasAuthorship W3106314465A5034794449 @default.
• W3106314465 hasAuthorship W3106314465A5048507138 @default.
• W3106314465 hasAuthorship W3106314465A5054276215 @default.
• W3106314465 hasAuthorship W3106314465A5061782485 @default.
• W3106314465 hasAuthorship W3106314465A5064971055 @default.
• W3106314465 hasAuthorship W3106314465A5071297179 @default.
• W3106314465 hasAuthorship W3106314465A5086636066 @default.
• W3106314465 hasBestOaLocation W31063144651 @default.
• W3106314465 hasConcept C104317684 @default.
• W3106314465 hasConcept C127716648 @default.
• W3106314465 hasConcept C131934819 @default.
• W3106314465 hasConcept C14036430 @default.
• W3106314465 hasConcept C143065580 @default.
• W3106314465 hasConcept C144464004 @default.
• W3106314465 hasConcept C146587185 @default.
• W3106314465 hasConcept C195794163 @default.

• next