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- W310633218 abstract "Supernatants (sups) from PHA-stimulated sublines derived from the T cell line LBRM-33 were screened for MAF activity (assessed by the activation of thioglycollate-induced PEC's to lyse /sup 125/I-IUDR labeled FBL target cells). A subline produced sups with high levels of MAF activity but lacking detectable anti-viral activity. ..gamma..IF, which also exhibits anti-viral activity, is the only well-defined MAF. Therefore, further studies were initiated to determine if LBRM MAF activity was distinct from ..gamma..IF. Examination of LBRM sups for ..gamma..IF, in an ELISA capable of detecting 10 units/ml by binding to a monoclonal antibody, detected no ..gamma..IF. By contrast, sups from Con A-stimulated spleen cells or media containing r..gamma..IF which exhibited similar MAF activity to the LBRM sups, contained 315 and 376 units/ml of ..gamma..IF in the ELISA, respectively. The extent to which ..gamma..IF potentially contributes to the MAF activity of LBRM sups is being further assessed. The presence of ..gamma..IF message in LBRM cells is being examined by blot analysis utilizing a probe for murine ..gamma..IF mRNA. The ability of a monoclonal anti-..gamma..IF, which inhibits the in vitro MAF activity of murine ..gamma..IF, to diminish LBRM-derived MAF activity is being determined. Further studies will attempt to isolate and characterize themore » lymphokine responsible for the LBRM-derived MAF activity.« less" @default.
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- W310633218 date "1986-03-05" @default.
- W310633218 modified "2023-09-23" @default.
- W310633218 title "Identification of a macrophage activation factor (MAF) distinct from gamma interferon (. gamma. IF) which induces macrophage cytotoxicity" @default.
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