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• W3106426477 abstract "Placenta accreta (PA) can be life-threatening due to postpartum hemorrhage and may lead to cesarean hysterectomy. We investigated the expression of Matrix metalloproteinase-2 (MMP-2), β-catenin, E-cadherin (E-CAD), transforming growth factor β1 (TGF-β1), glutathione peroxidase 1 (GPx-1), reduced glutathione (GSH) and superoxide dismutase (SOD) in PA compared to controls to determine if alterations may contribute to PA. Materials and methods: Twenty six PA and 31 controls were evaluated immunohistochemically for expression of MMP-2, β-catenin and E-CAD on villous and extravillous trophoblasts. TGF-β1 and GPx-1 mRNA levels were evaluated by rt-PCR. We measured biochemical levels of GSH and SOD. Results: Significant increases of MMP-2 immunoexpression, GPx-1 mRNA, SOD and GSH levels, decreases in immunoexpression of E-CAD and β-catenin and TGF-β1 mRNA were found in PA. Conclusion: These findings suggest that loss of cell-cell adhesion and increased antioxidants level may have a role in PA." @default.
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• W3106426477 date "2020-11-11" @default.
• W3106426477 modified "2023-10-01" @default.
• W3106426477 title "Possible Role of TGF-<i>β</i>1, MMP-2, E-CAD, <i>β</i>-Catenin and Antioxidants in Pathogenesis of Placenta Accreta" @default.
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• W3106426477 doi "https://doi.org/10.1080/15513815.2020.1843574" @default.
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