FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106521059> ?p ?o ?g. }

• W3106521059 endingPage "526" @default.
• W3106521059 startingPage "520" @default.
• W3106521059 abstract ": The main aim of current pediatric male fertility preservation programs is storing spermatogonia stem cell (SSC) prior to starting cancer treatment. From July 1st, 2014 to May 1st, 2020; 170 patients have been recruited in Wake Forest Testicular Tissue Banking Program. The existence of multiple testis biopsies in different time points and detailed histological analyses of a unique cancer patient, provided an educational opportunity to investigate testis condition in different phases of cancer management. A pediatric male cancer patient with B-cell acute lymphoblastic leukemia (ALL) had multiple testicular leukemia recurrences and went through several testicular biopsies, to identify leukemic infiltration as well as considering fertility preservation. Infiltration of leukemia cells into both testes was identified. Neither elongated spermatid nor sperm were detected, but germ cells including SSC, spermatocyte and round spermatid could be identified in the stored tissue even after initial cancer treatment. Different germ cells were identified by hematoxylin and eosin (H&E) staining and specific immunohistochemical (IHC) markers including PGP9.5/UCHL1 or MAGE-A4 (spermatogonia), SYCP3 (spermatocyte) and PRM1 (round spermatid). This emphasizes the importance of offering testicular biopsy to pediatric cancer patients at risk of infertility regardless to the stage of cancer treatment, although earlier biopsy is preferred. Promising research on in vitro spermatogenesis and auto-transplantation support the practice of SSC preservation. In addition, finding and storing round spermatids isolated from testicular biopsy provides a currently available option of round spermatid injection (ROSI). Given the complexity of managing cancer while considering fertility preservation, a multidisciplinary collaboration is important to achieve optimal overall outcomes." @default.
• W3106521059 created "2020-11-23" @default.
• W3106521059 creator A5008750218 @default.
• W3106521059 creator A5027290610 @default.
• W3106521059 creator A5030802910 @default.
• W3106521059 creator A5039364359 @default.
• W3106521059 creator A5054021581 @default.
• W3106521059 creator A5062414050 @default.
• W3106521059 creator A5064560180 @default.
• W3106521059 creator A5082261321 @default.
• W3106521059 creator A5090800488 @default.
• W3106521059 creator A5091346385 @default.
• W3106521059 date "2021-01-01" @default.
• W3106521059 modified "2023-10-01" @default.
• W3106521059 title "Fertility preservation for pediatric male cancer patients: illustrating contemporary and future options; a case report" @default.
• W3106521059 cites W1518114909 @default.
• W3106521059 cites W2036979203 @default.
• W3106521059 cites W2040804409 @default.
• W3106521059 cites W2050455567 @default.
• W3106521059 cites W2054743870 @default.
• W3106521059 cites W2089039784 @default.
• W3106521059 cites W2097295708 @default.
• W3106521059 cites W2137430106 @default.
• W3106521059 cites W2150060351 @default.
• W3106521059 cites W2150982942 @default.
• W3106521059 cites W2189905177 @default.
• W3106521059 cites W2274566290 @default.
• W3106521059 cites W2341482240 @default.
• W3106521059 cites W2590403902 @default.
• W3106521059 cites W2880775408 @default.
• W3106521059 cites W2887748979 @default.
• W3106521059 cites W2923543767 @default.
• W3106521059 cites W2937043913 @default.
• W3106521059 doi "https://doi.org/10.21037/tau-20-908" @default.
• W3106521059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7844490" @default.
• W3106521059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33532340" @default.
• W3106521059 hasPublicationYear "2021" @default.
• W3106521059 type Work @default.
• W3106521059 sameAs 3106521059 @default.
• W3106521059 citedByCount "4" @default.
• W3106521059 countsByYear W31065210592021 @default.
• W3106521059 countsByYear W31065210592023 @default.
• W3106521059 crossrefType "journal-article" @default.
• W3106521059 hasAuthorship W3106521059A5008750218 @default.
• W3106521059 hasAuthorship W3106521059A5027290610 @default.
• W3106521059 hasAuthorship W3106521059A5030802910 @default.
• W3106521059 hasAuthorship W3106521059A5039364359 @default.
• W3106521059 hasAuthorship W3106521059A5054021581 @default.
• W3106521059 hasAuthorship W3106521059A5062414050 @default.
• W3106521059 hasAuthorship W3106521059A5064560180 @default.
• W3106521059 hasAuthorship W3106521059A5082261321 @default.
• W3106521059 hasAuthorship W3106521059A5090800488 @default.
• W3106521059 hasAuthorship W3106521059A5091346385 @default.
• W3106521059 hasBestOaLocation W31065210591 @default.
• W3106521059 hasConcept C104317684 @default.
• W3106521059 hasConcept C121608353 @default.
• W3106521059 hasConcept C123765429 @default.
• W3106521059 hasConcept C126322002 @default.
• W3106521059 hasConcept C142724271 @default.
• W3106521059 hasConcept C143998085 @default.
• W3106521059 hasConcept C148196450 @default.
• W3106521059 hasConcept C16685009 @default.
• W3106521059 hasConcept C2775934546 @default.
• W3106521059 hasConcept C2776053789 @default.
• W3106521059 hasConcept C2776212926 @default.
• W3106521059 hasConcept C2776694085 @default.
• W3106521059 hasConcept C2776938808 @default.
• W3106521059 hasConcept C2777394357 @default.
• W3106521059 hasConcept C2777904497 @default.
• W3106521059 hasConcept C2908647359 @default.
• W3106521059 hasConcept C502942594 @default.
• W3106521059 hasConcept C518429986 @default.
• W3106521059 hasConcept C54355233 @default.
• W3106521059 hasConcept C71924100 @default.
• W3106521059 hasConcept C86803240 @default.
• W3106521059 hasConcept C99454951 @default.
• W3106521059 hasConceptScore W3106521059C104317684 @default.
• W3106521059 hasConceptScore W3106521059C121608353 @default.
• W3106521059 hasConceptScore W3106521059C123765429 @default.
• W3106521059 hasConceptScore W3106521059C126322002 @default.
• W3106521059 hasConceptScore W3106521059C142724271 @default.
• W3106521059 hasConceptScore W3106521059C143998085 @default.
• W3106521059 hasConceptScore W3106521059C148196450 @default.
• W3106521059 hasConceptScore W3106521059C16685009 @default.
• W3106521059 hasConceptScore W3106521059C2775934546 @default.
• W3106521059 hasConceptScore W3106521059C2776053789 @default.
• W3106521059 hasConceptScore W3106521059C2776212926 @default.
• W3106521059 hasConceptScore W3106521059C2776694085 @default.
• W3106521059 hasConceptScore W3106521059C2776938808 @default.
• W3106521059 hasConceptScore W3106521059C2777394357 @default.
• W3106521059 hasConceptScore W3106521059C2777904497 @default.
• W3106521059 hasConceptScore W3106521059C2908647359 @default.
• W3106521059 hasConceptScore W3106521059C502942594 @default.
• W3106521059 hasConceptScore W3106521059C518429986 @default.
• W3106521059 hasConceptScore W3106521059C54355233 @default.
• W3106521059 hasConceptScore W3106521059C71924100 @default.
• W3106521059 hasConceptScore W3106521059C86803240 @default.
• W3106521059 hasConceptScore W3106521059C99454951 @default.

• next