FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106562893> ?p ?o ?g. }

• W3106562893 endingPage "116055" @default.
• W3106562893 startingPage "116055" @default.
• W3106562893 abstract "We investigated the in vitro effects of pyriproxyfen on ionic balance in the testis of the zebrafish by measuring 45Ca2+ influx. In vivo pyriproxyfen treatment was carried out to study oxidative stress, and conduct morphological analysis of the testis and liver. Whole testes were incubated in vitro with/without pyriproxyfen (10−12, 10−9 or 10−6 M; 30 min) and 45Ca2+ influx determined. To study pyriproxyfen’s mechanism of action, inhibitors/activators of ionic channels or pumps/exchangers, protein kinase inhibitors or a calcium chelator were added 15 min before the addition of 45Ca2+ and pyriproxyfen. We evaluated the in vivo effects of 7 day exposure to waterborne pyriproxyfen (10−9 M) on reactive oxygen species (ROS) formation, lipid peroxidation, and reduced glutathione content (GSH), glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT) and γ-glutamyltransferase (GGT) activity. Morphological analyses of the testis and liver were carried out after in vivo exposure of D. rerio to pyriproxyfen. Pyriproxyfen increased 45Ca2+ influx by opening the voltage-dependent T-type channels (T-type VDCC), inhibiting sarco/endoplasmic reticulum 45Ca2+-ATPase (SERCA) and the NCX exchanger (forward mode) and by mobilizing calcium from stores. The involvement of potassium channels and protein kinase C (PKC) was also demonstrated in pyriproxyfen-induced intracellular calcium elevation. In vivo pyriproxyfen treatment of D. rerio increased lipid peroxidation, decreased GSH content and increased GST activity in testes, in addition to increasing the number and size of spermatogonia cysts and inducing hepatocyte basophilia and dilation of blood vessels in the liver. The toxicity of pyriproxyfen is mediated by calcium overload, increased lipid peroxidation, and a diminished antioxidant capacity in the testis, due to GSH depletion, and altered spermatogenesis. The development of high basophilia in the liver suggests that pyriproxyfen may have estrogenic activity, possibly acting as an endocrine-disruptor. These findings indicate that these alterations may contribute to pyriproxyfen toxicity and spermatogenesis disruption." @default.
• W3106562893 created "2020-12-07" @default.
• W3106562893 creator A5010140238 @default.
• W3106562893 creator A5012901791 @default.
• W3106562893 creator A5014172676 @default.
• W3106562893 creator A5023913673 @default.
• W3106562893 creator A5035613704 @default.
• W3106562893 creator A5056689696 @default.
• W3106562893 creator A5081390325 @default.
• W3106562893 creator A5083819936 @default.
• W3106562893 date "2021-02-01" @default.
• W3106562893 modified "2023-10-16" @default.
• W3106562893 title "Pyriproxyfen induces intracellular calcium overload and alters antioxidant defenses in Danio rerio testis that may influence ongoing spermatogenesis" @default.
• W3106562893 cites W1479789413 @default.
• W3106562893 cites W1581414347 @default.
• W3106562893 cites W1599277155 @default.
• W3106562893 cites W1608567816 @default.
• W3106562893 cites W1775749144 @default.
• W3106562893 cites W1970625109 @default.
• W3106562893 cites W1972738604 @default.
• W3106562893 cites W1986776736 @default.
• W3106562893 cites W1991699054 @default.
• W3106562893 cites W1992084502 @default.
• W3106562893 cites W2010965103 @default.
• W3106562893 cites W2017889315 @default.
• W3106562893 cites W2031389191 @default.
• W3106562893 cites W2031884363 @default.
• W3106562893 cites W2048290905 @default.
• W3106562893 cites W2089869610 @default.
• W3106562893 cites W2095018271 @default.
• W3106562893 cites W2102457004 @default.
• W3106562893 cites W2137399444 @default.
• W3106562893 cites W2144542356 @default.
• W3106562893 cites W2158334050 @default.
• W3106562893 cites W2489297787 @default.
• W3106562893 cites W2509780217 @default.
• W3106562893 cites W2779105801 @default.
• W3106562893 cites W2784202279 @default.
• W3106562893 cites W2792097424 @default.
• W3106562893 cites W2794215330 @default.
• W3106562893 cites W2796083719 @default.
• W3106562893 cites W2893327751 @default.
• W3106562893 cites W2897572384 @default.
• W3106562893 cites W2908415682 @default.
• W3106562893 cites W2910437770 @default.
• W3106562893 cites W2915730642 @default.
• W3106562893 cites W3004393446 @default.
• W3106562893 cites W3010885686 @default.
• W3106562893 cites W3013352992 @default.
• W3106562893 cites W3025778656 @default.
• W3106562893 cites W3036482161 @default.
• W3106562893 cites W3036728758 @default.
• W3106562893 doi "https://doi.org/10.1016/j.envpol.2020.116055" @default.
• W3106562893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33272804" @default.
• W3106562893 hasPublicationYear "2021" @default.
• W3106562893 type Work @default.
• W3106562893 sameAs 3106562893 @default.
• W3106562893 citedByCount "7" @default.
• W3106562893 countsByYear W31065628932021 @default.
• W3106562893 countsByYear W31065628932022 @default.
• W3106562893 countsByYear W31065628932023 @default.
• W3106562893 crossrefType "journal-article" @default.
• W3106562893 hasAuthorship W3106562893A5010140238 @default.
• W3106562893 hasAuthorship W3106562893A5012901791 @default.
• W3106562893 hasAuthorship W3106562893A5014172676 @default.
• W3106562893 hasAuthorship W3106562893A5023913673 @default.
• W3106562893 hasAuthorship W3106562893A5035613704 @default.
• W3106562893 hasAuthorship W3106562893A5056689696 @default.
• W3106562893 hasAuthorship W3106562893A5081390325 @default.
• W3106562893 hasAuthorship W3106562893A5083819936 @default.
• W3106562893 hasConcept C126322002 @default.
• W3106562893 hasConcept C134018914 @default.
• W3106562893 hasConcept C178790620 @default.
• W3106562893 hasConcept C181199279 @default.
• W3106562893 hasConcept C185592680 @default.
• W3106562893 hasConcept C2775838275 @default.
• W3106562893 hasConcept C2776151105 @default.
• W3106562893 hasConcept C2780829032 @default.
• W3106562893 hasConcept C519063684 @default.
• W3106562893 hasConcept C538909803 @default.
• W3106562893 hasConcept C55493867 @default.
• W3106562893 hasConcept C71924100 @default.
• W3106562893 hasConcept C86803240 @default.
• W3106562893 hasConcept C98274493 @default.
• W3106562893 hasConceptScore W3106562893C126322002 @default.
• W3106562893 hasConceptScore W3106562893C134018914 @default.
• W3106562893 hasConceptScore W3106562893C178790620 @default.
• W3106562893 hasConceptScore W3106562893C181199279 @default.
• W3106562893 hasConceptScore W3106562893C185592680 @default.
• W3106562893 hasConceptScore W3106562893C2775838275 @default.
• W3106562893 hasConceptScore W3106562893C2776151105 @default.
• W3106562893 hasConceptScore W3106562893C2780829032 @default.
• W3106562893 hasConceptScore W3106562893C519063684 @default.
• W3106562893 hasConceptScore W3106562893C538909803 @default.
• W3106562893 hasConceptScore W3106562893C55493867 @default.
• W3106562893 hasConceptScore W3106562893C71924100 @default.
• W3106562893 hasConceptScore W3106562893C86803240 @default.
• W3106562893 hasConceptScore W3106562893C98274493 @default.

• next