Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106574839> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3106574839 endingPage "972" @default.
- W3106574839 startingPage "966" @default.
- W3106574839 abstract "Objective: To elucidate the relationship between the myositis autoantibodies and clinical phenotypes of juvenile dermatomyositis (JDM). Methods: A total of 76 JDM patients admitted to the Children's Hospital of Chongqing Medical University from January 2017 to May 2020 were tested for myositis autoantibodies, including myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs). Kruskal-Wallis test and logistic regression were used to analyze the relationship between the antibodies and clinical characteristics. Results: In the 76 cases, 37 were females and 39 males. Forty-three cases (53%) were MSAs positive, among which the most common subtypes were autoantibodies against nuclear matrix protein 2 (NXP2) (15/76, 20%), melanoma differentiation-associated protein 5 (MDA5) (13/76, 17%) and transcription intermediary factor 1 gamma (9/76, 11%). While 20 cases (26%) were positive for MAAs, among which anti-Ro-52 antibody (17/76, 22%) was the most common subtype. Sixteen patients (21%) had both MAAs and MSAs. The incidences of arthritis (9 cases), fever (8 cases), skin ulcers (5 cases) and macrophage activation syndrome (MAS) (1 case) were significantly higher in the patients with anti-MDA5 antibody among the antibody groups. Dysphasia (6 cases) and edema (8 cases) mainly occurred in patients with anti-NXP2 antibody. Children with anti-MDA5 antibody were more likely to develop arthritis (OR=10.636, 95%CI: 2.770-40.844, P=0.001), skin ulcers (OR=12.500, 95%CI: 2.498-62.522, P=0.002), fever (OR=5.600, 95%CI: 1.580-19.849, P=0.008) and interstitial lung disease (ILD) (OR=23.333, 95%CI: 4.750-114.616, P<0.01). In the patients with different subtypes of MSAs, the creatine kinase value was significantly lower in the anti-MDA5 group than those in the anti-aminoacyl-tRNA synthetase (P=0.03), anti-NXP2 (P<0.01), and MSAs-negative group (P=0.013). Conclusions: Most children with JDM have positive myositis autoantibodies, and will present with different clinical phenotypes based on different autoantibodies. And children with anti-MDA5 antibodies are likely to develop ILD and MAS. Therefore the detection of myositis-specific autoantibodies is important." @default.
- W3106574839 created "2020-12-07" @default.
- W3106574839 creator A5005517592 @default.
- W3106574839 creator A5042795113 @default.
- W3106574839 creator A5048841617 @default.
- W3106574839 creator A5075520064 @default.
- W3106574839 creator A5091179510 @default.
- W3106574839 date "2020-12-02" @default.
- W3106574839 modified "2023-09-29" @default.
- W3106574839 title "The analysis of clinical phenotypes and autoantibodies in juvenile dermatomyositis" @default.
- W3106574839 doi "https://doi.org/10.3760/cma.j.cn112140-20200724-00751" @default.
- W3106574839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33256317" @default.
- W3106574839 hasPublicationYear "2020" @default.
- W3106574839 type Work @default.
- W3106574839 sameAs 3106574839 @default.
- W3106574839 citedByCount "3" @default.
- W3106574839 countsByYear W31065748392021 @default.
- W3106574839 countsByYear W31065748392022 @default.
- W3106574839 crossrefType "journal-article" @default.
- W3106574839 hasAuthorship W3106574839A5005517592 @default.
- W3106574839 hasAuthorship W3106574839A5042795113 @default.
- W3106574839 hasAuthorship W3106574839A5048841617 @default.
- W3106574839 hasAuthorship W3106574839A5075520064 @default.
- W3106574839 hasAuthorship W3106574839A5091179510 @default.
- W3106574839 hasConcept C126322002 @default.
- W3106574839 hasConcept C159654299 @default.
- W3106574839 hasConcept C16005928 @default.
- W3106574839 hasConcept C163764329 @default.
- W3106574839 hasConcept C203014093 @default.
- W3106574839 hasConcept C2777077863 @default.
- W3106574839 hasConcept C2778552304 @default.
- W3106574839 hasConcept C2778751314 @default.
- W3106574839 hasConcept C2781232998 @default.
- W3106574839 hasConcept C71924100 @default.
- W3106574839 hasConcept C90924648 @default.
- W3106574839 hasConceptScore W3106574839C126322002 @default.
- W3106574839 hasConceptScore W3106574839C159654299 @default.
- W3106574839 hasConceptScore W3106574839C16005928 @default.
- W3106574839 hasConceptScore W3106574839C163764329 @default.
- W3106574839 hasConceptScore W3106574839C203014093 @default.
- W3106574839 hasConceptScore W3106574839C2777077863 @default.
- W3106574839 hasConceptScore W3106574839C2778552304 @default.
- W3106574839 hasConceptScore W3106574839C2778751314 @default.
- W3106574839 hasConceptScore W3106574839C2781232998 @default.
- W3106574839 hasConceptScore W3106574839C71924100 @default.
- W3106574839 hasConceptScore W3106574839C90924648 @default.
- W3106574839 hasIssue "12" @default.
- W3106574839 hasLocation W31065748391 @default.
- W3106574839 hasOpenAccess W3106574839 @default.
- W3106574839 hasPrimaryLocation W31065748391 @default.
- W3106574839 hasRelatedWork W2102540186 @default.
- W3106574839 hasRelatedWork W2267304422 @default.
- W3106574839 hasRelatedWork W2275078589 @default.
- W3106574839 hasRelatedWork W2361732572 @default.
- W3106574839 hasRelatedWork W2371700845 @default.
- W3106574839 hasRelatedWork W2538749261 @default.
- W3106574839 hasRelatedWork W2560335553 @default.
- W3106574839 hasRelatedWork W2746773579 @default.
- W3106574839 hasRelatedWork W2784981423 @default.
- W3106574839 hasRelatedWork W2804031565 @default.
- W3106574839 hasRelatedWork W2887722675 @default.
- W3106574839 hasRelatedWork W2922272744 @default.
- W3106574839 hasRelatedWork W3013714833 @default.
- W3106574839 hasRelatedWork W3094732758 @default.
- W3106574839 hasRelatedWork W3115534872 @default.
- W3106574839 hasRelatedWork W3133701133 @default.
- W3106574839 hasRelatedWork W3135258186 @default.
- W3106574839 hasRelatedWork W3187060018 @default.
- W3106574839 hasRelatedWork W3201357023 @default.
- W3106574839 hasRelatedWork W3204127984 @default.
- W3106574839 hasVolume "58" @default.
- W3106574839 isParatext "false" @default.
- W3106574839 isRetracted "false" @default.
- W3106574839 magId "3106574839" @default.
- W3106574839 workType "article" @default.