Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106577029> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3106577029 abstract "Background TDF and ETV are first-line treatments for CHB virus infection. A recent analysis of nationwide insurance data from Korea suggested that the risk of HCC may vary by type of CHB treatment; however, this finding was based on a limited follow-up period following TDF approval in Korea in 2012 and has not been replicated in large datasets outside of Asia. The objective of this analysis was to explore the long-term risk of HCC with TDF vs. ETV in treatment naive (TN) CHB patients in a US administrative claims dataset. Methods Among 158,272 patients with evidence of CHB and administrative medical claims between January 2006 and September 2018, we identified TN patients exposed to TDF (N=6,145) or ETV (N=4,046) with at least 1 year of continuous enrollment prior to cohort entry. Exclusion criteria included coinfection with HCV, HDV, or HIV; prior exposure to peginterferon or nucleos(t)ide analogues; HCC or liver transplant prior or up to 6 months after initiating treatment. Absolute rates and corresponding 95% CIs were determined for each treatment group, Cox proportional hazards methods were used to estimate the risk of incident HCC associated with TDF vs ETV. To account for the effects of potential differences in demographics and baseline health status, we incorporated multivariable adjustment and weighting based on treatment propensity scores. Results Median follow-up duration was comparable in TDF- vs ETV-treated patients among TDF-treated CHB patients, the absolute rate of HCC was approximately half that of patients treated with ETV (0.32 per 100 PY (CI: 0.23 – 0.43) vs 0.61 per 100 PY (CI: 0.45 – 0.80)). After adjustment for age group, sex, baseline health conditions and propensity score weighting, TDF remained associated with a significantly decreased risk of HCC compared to treatment with ETV (HR: 0.56, CI: 0.37 – 0.86). Conclusions In this analysis of commercially insured, TN CHB patients in the US, the absolute rate of HCC was lower in those treated with TDF than with ETV. After adjustment, treatment with TDF remained associated with a significantly decreased long term risk of HCC, consistent with recent findings from Asia." @default.
- W3106577029 created "2020-12-07" @default.
- W3106577029 creator A5012619112 @default.
- W3106577029 creator A5014107752 @default.
- W3106577029 creator A5030408366 @default.
- W3106577029 creator A5043249527 @default.
- W3106577029 creator A5046835105 @default.
- W3106577029 creator A5050079986 @default.
- W3106577029 creator A5065063010 @default.
- W3106577029 creator A5085882972 @default.
- W3106577029 creator A5091841617 @default.
- W3106577029 date "2020-11-01" @default.
- W3106577029 modified "2023-09-23" @default.
- W3106577029 title "IDDF2020-ABS-0057 Risk of incident hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) virus-infected patients treated with tenofovir disoproxil fumarate (TDF) versus entecavir (ETV): a US administrative claims analysis" @default.
- W3106577029 doi "https://doi.org/10.1136/gutjnl-2020-iddf.140" @default.
- W3106577029 hasPublicationYear "2020" @default.
- W3106577029 type Work @default.
- W3106577029 sameAs 3106577029 @default.
- W3106577029 citedByCount "0" @default.
- W3106577029 crossrefType "proceedings-article" @default.
- W3106577029 hasAuthorship W3106577029A5012619112 @default.
- W3106577029 hasAuthorship W3106577029A5014107752 @default.
- W3106577029 hasAuthorship W3106577029A5030408366 @default.
- W3106577029 hasAuthorship W3106577029A5043249527 @default.
- W3106577029 hasAuthorship W3106577029A5046835105 @default.
- W3106577029 hasAuthorship W3106577029A5050079986 @default.
- W3106577029 hasAuthorship W3106577029A5065063010 @default.
- W3106577029 hasAuthorship W3106577029A5085882972 @default.
- W3106577029 hasAuthorship W3106577029A5091841617 @default.
- W3106577029 hasBestOaLocation W31065770291 @default.
- W3106577029 hasConcept C126322002 @default.
- W3106577029 hasConcept C159047783 @default.
- W3106577029 hasConcept C17923572 @default.
- W3106577029 hasConcept C207103383 @default.
- W3106577029 hasConcept C2522874641 @default.
- W3106577029 hasConcept C2776175608 @default.
- W3106577029 hasConcept C2777382497 @default.
- W3106577029 hasConcept C2777813720 @default.
- W3106577029 hasConcept C2777869810 @default.
- W3106577029 hasConcept C2778019345 @default.
- W3106577029 hasConcept C2779344132 @default.
- W3106577029 hasConcept C2780593183 @default.
- W3106577029 hasConcept C3013748606 @default.
- W3106577029 hasConcept C44249647 @default.
- W3106577029 hasConcept C50382708 @default.
- W3106577029 hasConcept C71924100 @default.
- W3106577029 hasConcept C72563966 @default.
- W3106577029 hasConcept C90924648 @default.
- W3106577029 hasConceptScore W3106577029C126322002 @default.
- W3106577029 hasConceptScore W3106577029C159047783 @default.
- W3106577029 hasConceptScore W3106577029C17923572 @default.
- W3106577029 hasConceptScore W3106577029C207103383 @default.
- W3106577029 hasConceptScore W3106577029C2522874641 @default.
- W3106577029 hasConceptScore W3106577029C2776175608 @default.
- W3106577029 hasConceptScore W3106577029C2777382497 @default.
- W3106577029 hasConceptScore W3106577029C2777813720 @default.
- W3106577029 hasConceptScore W3106577029C2777869810 @default.
- W3106577029 hasConceptScore W3106577029C2778019345 @default.
- W3106577029 hasConceptScore W3106577029C2779344132 @default.
- W3106577029 hasConceptScore W3106577029C2780593183 @default.
- W3106577029 hasConceptScore W3106577029C3013748606 @default.
- W3106577029 hasConceptScore W3106577029C44249647 @default.
- W3106577029 hasConceptScore W3106577029C50382708 @default.
- W3106577029 hasConceptScore W3106577029C71924100 @default.
- W3106577029 hasConceptScore W3106577029C72563966 @default.
- W3106577029 hasConceptScore W3106577029C90924648 @default.
- W3106577029 hasLocation W31065770291 @default.
- W3106577029 hasOpenAccess W3106577029 @default.
- W3106577029 hasPrimaryLocation W31065770291 @default.
- W3106577029 hasRelatedWork W13313111 @default.
- W3106577029 hasRelatedWork W14186601 @default.
- W3106577029 hasRelatedWork W14750688 @default.
- W3106577029 hasRelatedWork W15498277 @default.
- W3106577029 hasRelatedWork W16374216 @default.
- W3106577029 hasRelatedWork W2026279 @default.
- W3106577029 hasRelatedWork W2522340 @default.
- W3106577029 hasRelatedWork W4310718 @default.
- W3106577029 hasRelatedWork W6918463 @default.
- W3106577029 hasRelatedWork W9508581 @default.
- W3106577029 isParatext "false" @default.
- W3106577029 isRetracted "false" @default.
- W3106577029 magId "3106577029" @default.
- W3106577029 workType "article" @default.