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• W3106604787 startingPage "62" @default.
• W3106604787 abstract "Ovarian cancer is the most significant cause of gynecological cancer mortality, with the majority of women with advanced disease. Although surgery and chemotherapy can enhance survival rates, the 5-year survival rates remain low at 45%. So, alternative treatment options need to be implemented to improve therapeutic outcomes. In the ovarian cancer tumor, the presence of T cells helps to improve the progression-free and overall survival, whereas a poor prognosis corresponds to the presence of regulatory T cells and expression of T cells inhibitory molecules. Analyzing the important role of these immune systems in cancer management, immunotherapy may create a sustained response to recurring ovarian cancer cells in the immune system. In addition, by boosting anti-tumor immune response, women’s prognosis with this lethal disease can be significantly influenced. Different immunotherapeutic strategies and nanoparticle-based strategies were used as potential treatment options to challenge tumor progression. This review discusses cytokine therapy, peptide vaccine, monoclonal antibody, dendritic cell-based vaccine, adoptive T cells transfer, and immune checkpoint inhibitors as well as different nanoparticles such as poly (lactic-co-glycolic) acid nanoparticles, polyethyleneimine-based nanoparticles, and liposomes that offer a new paradigm in the treatment of ovarian cancer." @default.
• W3106604787 created "2020-12-07" @default.
• W3106604787 creator A5022659794 @default.
• W3106604787 creator A5043739833 @default.
• W3106604787 creator A5055174079 @default.
• W3106604787 date "2021-02-01" @default.
• W3106604787 modified "2023-10-17" @default.
• W3106604787 title "Immunotherapeutic strategies for the treatment of ovarian cancer: current status and future direction" @default.
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