Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106680822> ?p ?o ?g. }
- W3106680822 abstract "Irf6 and Esrp1 are important for palate development across vertebrates. In zebrafish, we found that irf6 regulates the expression of esrp1. We detailed overlapping Irf6 and Esrp1/2 expression in mouse orofacial epithelium. In zebrafish, irf6 and esrp1/2 share expression in periderm, frontonasal ectoderm, and oral epithelium. Genetic disruption of irf6 and esrp1/2 in zebrafish resulted in cleft of the anterior neurocranium. The esrp1/2 mutant also developed cleft of the mouth opening. Lineage tracing of cranial neural crest cells revealed that cleft resulted not from migration defect, but from impaired chondrogenesis. Analysis of aberrant cells within the cleft revealed expression of sox10, col1a1 and irf6 and were adjacent to cells krt4 and krt5 positive. Breeding of mouse Irf6;Esrp1;Esrp2 compound mutants suggested genetic interaction, as the triple homozygote and the Irf6;Esrp1 double homozygote was not observed. Further, Irf6 heterozygosity reduced Esrp1/2 cleft severity. These studies highlight the complementary analysis of Irf6 and Esrp1/2 in mouse and zebrafish and captured a unique aberrant cell population expressing sox10, col1a1 and irf6. Future work characterizing this cell population will yield additional insight into cleft pathogenesis." @default.
- W3106680822 created "2020-12-07" @default.
- W3106680822 creator A5009601097 @default.
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- W3106680822 date "2020-01-01" @default.
- W3106680822 modified "2023-10-06" @default.
- W3106680822 title "An <i>Irf6</i>-<i>Esrp1/2</i> regulatory axis controls midface morphogenesis in vertebrates" @default.
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- W3106680822 doi "https://doi.org/10.1242/dev.194498" @default.
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- W3106680822 hasPublicationYear "2020" @default.
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